Construction of HClO activated near-infrared fluorescent probe for imaging hepatocellular carcinoma

Recent progress of organic fluorescent molecules for bioimaging applications: cancer-relevant biomarkers

“…In addition, MBH-MT has been successfully used for early diagnosis and guidance of cancer surgery. 91 5.3 Superoxide anion (O 2…”

A selenide-based coumarin fluorescent probe for fluorescence imaging of hypochlorous acid in cells and zebrafish

“…[17][18][19][20][21][22][23][24][25] These probes can be categorized by their response mechanisms, including electron-rich aromatic group elimination, oxygenation of chalcogenide elements, and oxidative cleavage of electron-rich double bonds. [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] Park and Ahn et al developed a silicon-rhodamine-based near-infrared fluorescent probe for sensitive detection of hypochlorous acid levels in mouse brain tissue models. 32 The probe exhibits excellent photostability and biocompatibility, yet synthesizing probe molecules poses significant challenges.…”

A phosphine-based fluorescent probe for fluorescent imaging of hypochlorous acid in living cells and zebrafish

“…9–13 Many HOCl fluorescence probes have been developed based on different reporting groups, such as oxidation reactions based on chalcogen atoms, selective oxidation of oximes and hydrazones, oxidative deprotection of amino phenols, and oxidation cleavage of electron-deficient double bonds, resulting in probes with excellent photophysical properties (see Table S1, ESI†). 14–37 However, some probes still have shortcomings, such as low sensitivity, poor photostability, unsatisfactory quantum yield, and short excitation and emission wavelengths. 38,39 Precise in situ imaging of HOCl in living organisms remains challenging due to its short lifespan and high reactivity.…”