Recent progress of organic fluorescent molecules for bioimaging applications: cancer-relevant biomarkers

Zhang, Chun; Sun, Yi-Tao; Gan, Suya; Ren, Aimin; Milaneh, Slieman; Xiang, Da-Jun; Wang, Wen-Long

doi:10.1039/d3tc03664b

Cited by 2 publications

(1 citation statement)

References 112 publications

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“…Our group had been focusing on the development of PTP modulators for decades, and developed several fluorescent SHP1 inhibitors as tools to investigate the SHP1 biological function in the complex and dynamic intracellular environment. − Thus, to enrich the diversity of SHP1 fluorescent inhibitor skeletons, all the synthesized isatin compounds were further evaluated against SHP1 PTP by using a broad-spectrum phosphatase inhibitor, NSC87877, as a positive control for SHP1 PTP . Among compounds 3a–3f , compounds with an electron-donor group (−NH 2 , −OMe) and an alkyl group (-methyl, -ethyl, -propyl) on the phenyl ring showed weaker inhibitory activities than the corresponding compound 3a .…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Fluorescence, and Bioactivity of Novel Isatin Derivatives

Dong,

Gao,

Cao

et al. 2024

J. Phys. Chem. B

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Section: Resultsmentioning

confidence: 99%

Synthesis, Fluorescence, and Bioactivity of Novel Isatin Derivatives

Dong,

Gao,

Cao

et al. 2024

J. Phys. Chem. B

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3‐Ethoxysalicylaldimine‐based symmetrical azine‐linked luminogen exhibiting ESIPT and bright orange colour AIE behaviour with live cell bioimaging application

Mathivanan,

Shanmugaraj,

Ilanchelian

et al. 2024

Luminescence

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Herein, we describe the design and development of a new cell‐permeable aggregation‐induced emission (AIE) active 3‐ethoxysalicylaldimine‐based symmetrical azine molecule HDBE. The synthesized compound underwent comprehensive investigation of different spectroscopic methods, like NMR, mass and single crystal X‐ray diffraction analysis. The fluorophore HDBE exhibited the bright orange colour AIE behaviour in THF–H2O mixture. The drastic enhancement of emission was achieved upon adding the water to the THF solution of HDBE, with a concentration of 90%. Along with the dynamic light scattering (DLS) and quantum yield measurements, the formation of aggregates was also verified by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis. Further, HDBE demonstrated excited state intramolecular proton transfer (ESIPT) characteristics in different polarity of solvents, which was corroborated by absorption, emission and lifetime spectroscopical investigations. The detailed scrutiny of X‐ray structure of HDBE displayed the two strong intramolecular hydrogen bonding interactions, while solid‐state fluorescent spectra showed dual emission that corresponds to enol and keto form confirming the ESIPT feature. Further, the synthesized AIE molecule was non‐toxic and cell‐permeable, making it easy to label as a biomarker in live HeLa cells via fluorescent bioimaging. These studies offer a quick and easy way to develop both AIE and ESIPT‐coupled molecules for live cell bioimaging applications.

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Recent progress of organic fluorescent molecules for bioimaging applications: cancer-relevant biomarkers

Abstract: The work reports the progress of small-fluorescent molecules for bioimaging applications to cancer-relevant biomarkers H+, NO, H2S and reactive oxygen species (H2O2, HClO, O2˙−, 1O2 and ˙OH) over the past six years.

Cited by 2 publications

References 112 publications

Synthesis, Fluorescence, and Bioactivity of Novel Isatin Derivatives

Synthesis, Fluorescence, and Bioactivity of Novel Isatin Derivatives

3‐Ethoxysalicylaldimine‐based symmetrical azine‐linked luminogen exhibiting ESIPT and bright orange colour AIE behaviour with live cell bioimaging application

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