Construction of carbon nanotube based nanoarchitectures for selective impedimetric detection of cancer cells in whole blood

Liu, Yang; Zhu, Fanjiao; Dan, Wangxia; Fu, Yu Can; Liu, Shaoqin

doi:10.1039/c4an00758a

Cited by 42 publications

(23 citation statements)

References 43 publications

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“…Therefore, an electrochemical biosensor based on cell impedance sensing technology can measure changes in cell layer resistance caused by cell morphology, cell movement, or cell contact, which can monitor cell dynamic behavior in real time quantitatively without damage (Fig ). Based on the above principles, researchers have constructed various electrochemical impedance sensors with modified working electrodes based on the innovative technique of capturing tumor cells, and the detection of the following human tumor cells has been demonstrated: HeLa, MCF‐7 (breast cancer), HL‐60 (human promyeloacute leukemia cell line), HCT‐116 (human colorectal cancer cells) and HepG2 (hepatocellular carcinomas) …”

Section: Electrochemical Biosensor In Tumor Cell Detectionmentioning

confidence: 99%

“…Based on the above principles, researchers have constructed various electrochemical impedance sensors with modified working electrodes based on the innovative technique of capturing tumor cells, and the detection of the following human tumor cells has been demonstrated: HeLa, MCF-7 (breast cancer), HL-60 (human promyeloacute leukemia cell line), HCT-116 (human colorectal cancer cells) and HepG2 (hepatocellular carcinomas). [11][12][13]22,[31][32][33] The most important step in building the cell electrochemical sensor is to fix the cells onto the surface of the working electrode to produce electrochemical signals. The traditional fixing method has some disadvantages, such as low survival rate, poor stability, additional increase in diffusion resistance and so on.…”

Section: Electrochemical Biosensor In Tumor Cell Detectionmentioning

confidence: 99%

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Application of electrochemical biosensors in tumor cell detection

Zhang

et al. 2020

Thoracic Cancer

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Conventional methods for detecting tumors, such as immunological methods and histopathological diagnostic techniques, often request high analytical costs, complex operation, long turnaround time, experienced personnel and high false‐positive rates. In addition, these assays are difficult to obtain an early diagnosis and prognosis quickly for malignant tumors. Compared with traditional technology, electrochemical technology has realized the study of interface charge transfer behavior at the atomic and molecular levels, which has become an important analytical and detection tool in contemporary analytical science. Electrochemical technique has the advantages of rapid detection, high sensitivity (single cell) and specificity in the detection of tumor cells, which has not only been successful in differentiating tumor cells from normal cells, but has also achieved targeted detection of localized tumor cells and circulating tumor cells. Electrochemical biosensors provide powerful tools for early diagnosis, staging and prognosis of tumors in clinical medicine. Therefore, this review mainly discusses the development and application of electrochemical biosensors in tumor cell detection in recent years.

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Section: Electrochemical Biosensor In Tumor Cell Detectionmentioning

confidence: 99%

Section: Electrochemical Biosensor In Tumor Cell Detectionmentioning

confidence: 99%

Application of electrochemical biosensors in tumor cell detection

Zhang

et al. 2020

Thoracic Cancer

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“…Another example of using the electrical properties of CNTs for detection of CTCs from whole-blood samples was demonstrated in a recent study by Liu et al 106 The researchers developed a sensitive CNT-based biosensor for direct detection of CTCs in whole blood using the good conductivity of MWCNTs. This biosensing method is based on binding of anti-EpCAM antibodies to cancer cells, resulting in increased electron-transfer resistance.…”

Section: Carbon Nanotubesmentioning

confidence: 99%

“…The detection of cells was limited to five cells per mL of blood, and an electrical response was observed that was proportional to the concentration of liver cancer cells. 54,106…”

Section: Carbon Nanotubesmentioning

confidence: 99%

<p>Is small smarter? Nanomaterial-based detection and elimination of circulating tumor cells: current knowledge and perspectives</p>

Gribko

Künzel

Wünsch

et al. 2019

IJN

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Circulating tumor cells (CTCs) are disseminated cancer cells. The occurrence and circulation of CTCs seem key for metastasis, still the major cause of cancer-associated deaths. As such, CTCs are investigated as predictive biomarkers. However, due to their rarity and heterogeneous biology, CTCs’ practical use has not made it into the clinical routine. Clearly, methods for the effective isolation and reliable detection of CTCs are urgently needed. With the development of nanotechnology, various nanosystems for CTC isolation and enrichment and CTC-targeted cancer therapy have been designed. Here, we summarize the relationship between CTCs and tumor metastasis, and describe CTCs’ unique properties hampering their effective enrichment. We comment on nanotechnology-based systems for CTC isolation and recent achievements in microfluidics and lab-on-a-chip technologies. We discuss recent advances in CTC-targeted cancer therapy exploiting the unique properties of nanomaterials. We conclude by introducing developments in CTC-directed nanosystems and other advanced technologies currently in (pre)clinical research.

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“…A recent study by Liu et al demonstrated a quantitative CNT-based sensor for direct detection of cancer cells in whole blood using real time electrical impedance sensing [110]. Multilayer CNTs were assembled on an indium tin oxide (ITO) electrode surface and modified with EpCAM antibodies.…”

Section: Optical Nanoparticlesmentioning

confidence: 99%

Nanotechnology for Enrichment and Detection of Circulating Tumor Cells

Bhana

Wang

Huang

2015

Nanomedicine (Lond.)

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Circulating tumor cells (CTCs) are a hallmark of invasive behavior of cancer, responsible for the development of metastasis. Their detection and analysis have significant impacts in cancer biology and clinical practice. However, CTCs are rare events and contain heterogeneous subpopulations, requiring highly sensitive and specific techniques to identify and capture CTCs with high efficiency. Nanotechnology shows strong promises for CTC enrichment and detection owning to the unique structural and functional properties of nanoscale materials. In this review, we discuss the CTC enrichment and detection technologies based on a variety of functional nanosystems and nanostructured substrates, with the goal to highlight the role of nanotechnology in the advancement of basic and clinical CTC research.

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Construction of carbon nanotube based nanoarchitectures for selective impedimetric detection of cancer cells in whole blood

Cited by 42 publications

References 43 publications

Application of electrochemical biosensors in tumor cell detection

Application of electrochemical biosensors in tumor cell detection

<p>Is small smarter? Nanomaterial-based detection and elimination of circulating tumor cells: current knowledge and perspectives</p>

Nanotechnology for Enrichment and Detection of Circulating Tumor Cells

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