Construction of Au@Metal-organic framework for sensitive determination of creatinine in urine

Abstract

Creatinine level in urine is an important biomarker for renal function diseases, such as renal failure, glomerulonephritis, and chronic nephritis. The Au@MIL-101(Fe) was prepared by in situ growth of Au nanoparticles in MIL-101(Fe) as a selective SERS substrate. The Au@MIL-101(Fe) offers the great local surface plasmon resonance (SPR) effect due to gold nanoparticles aggregation inside metal-organic frameworks. The framework structure could enrich trace target samples and drag them into SPR hot spots. The optimal Au@MIL-101(Fe) composite substrate is used for analyzing creatinine in urine and the limit of detection is down to 0.1[Formula: see text][Formula: see text]mol/L and a linear relationship is ranging from 1[Formula: see text][Formula: see text]mol/L to 100[Formula: see text][Formula: see text]mol/L.

Metal–organic framework-derived photoelectrochemical sensors: structural design and biosensing technology

“…Thereby, Jiang et al fabricated Au@MIL-101(Fe) as a SERS substrate using the solution impregnation method to monitor creatinine precisely. 139 The SERS substrate was constructed by mixing pre-synthesized MIL-101(Fe) with chloroauric acid to form ultra-small nanoparticles on the surface. The framework structure could drag creatinine into the neighborhood of Au by the strong electrostatic interaction.…”

Metal–organic framework-based SERS sensing platforms for life and health detection

“…5C-F). 56 They rapidly added a sodium citrate solution to prepare the AuNPs. The team constructed a SERS sensing platform to monitor creatinine in urine using the AuNPs@MIL-101 composite materials.…”

SPR-Based Sensor for the Early Detection or Monitoring of Kidney Problems

“…In another study, metal-organic frameworks (MOFs) are used as LSPR sensors, with AuNPs serving as the metal clusters and joints and MIL-101(Fe) serving as the organic linkers [ 89 ]. Coordination bonds and molecular interaction between metal joints and organic linker struts form the interconnected network.…”

“…MOFs have high catalytic activity, large surface area, anda variety of bonding interactions with analytes, making them an attractive candidate for sensing applications. Jiang et al fabricated Au@MIL-101(Fe)-based SERS sensors with the in-situ growth of AuNPs in MIL-101(Fe) [ 89 ]. The device is extremely sensitive to low creatinine concentrations in urine, with a LOD of 1 × 10 −4 mM and a detection range of 10 −3 —10 −1 mM.…”

“…Taking advantage of electrostatic force to enrich the porous MIL-101(Fe) structure, the significantly improved Raman scattering signal was attributed to creatinine molecules approaching closer to the AuNPs vicinity and thus increasing the Raman scattering signal (d). The accumulation of metals within MOFs is thought to be responsible for the abundance of LSPR hot spots, as MIL-101(Fe) could serve as a suitable platform for the binding of AuNPs [ 89 ].…”