Construction of a Rough Surface with Submicron Ti2Cu Particle on Ti-Cu Alloy and Its Effect on the Antibacterial Properties and Cell Biocompatibility

Xie, Yanchun; Lu, Mingyuan; Cui, Shenshen; Yu, Hailong; Ke, Hongdan; Zhang, Erlin

doi:10.3390/met12061008

Cited by 6 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, Xie et al. [ 237 ] confirmed that the existence of MAPD between Ti 2 Cu and the matrix results in the antibacterial effect of the Ti–Cu alloy. Thus, the formation of Ti 2 Cu phase plays a pivotal role in the antibacterial behavior of Ti–Cu alloys [ 238 ].…”

Section: Ti–cu Antibacterial Implantsmentioning

confidence: 99%

Antibacterial Ti–Cu implants: A critical review on mechanisms of action

Mahmoudi¹,

Akbarpour²,

Lakeh³

et al. 2022

Materials Today Bio

View full text Add to dashboard Cite

Section: Ti–cu Antibacterial Implantsmentioning

confidence: 99%

Antibacterial Ti–Cu implants: A critical review on mechanisms of action

Mahmoudi¹,

Akbarpour²,

Lakeh³

et al. 2022

Materials Today Bio

View full text Add to dashboard Cite

“…For example, in order to improve the interface bonding strength of the dental implant and bone tissue, a rough surface was produced on the surface of the dental implant by means of SLA [26], the selective etching process [9], etc. It was reported the surface roughness should be 1.5 µm to 2.5 µm in order to obtain satisfactory bonding strength [27,28]. It has also been shown that titanium oxide (TiO 2 ) films grown spontaneously on the surface of titanium alloys are bioinert, often leading to inadequate bone integration [29][30][31].…”

Section: Surface Morphology and Chemical Compositionmentioning

confidence: 99%

Enhancing the Antibacterial Properties and Biocompatibility of Ti-Cu Alloy by Roughening and Anodic Oxidation

Xie

Mao

et al. 2022

Metals

Self Cite

View full text Add to dashboard Cite

Although Ti-Cu alloys have been shown to possess good antibacterial properties, they are still biologically inert. In this study, sandblasting and acid etching combined with anodic oxidation were applied to roughen the surface as well as to form a TiO2/CuO/Cu2O composite film, which would benefit both the antibacterial properties and the biocompatibility. The surface morphology, the phase composition, and the physicochemical properties were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). Electrochemical testing and inductively coupled plasma spectrometry (ICP) were used to determine the corrosion resistance and Cu ion release, the plate counting method was used to evaluate the antibacterial performance, and the CCK-8 method was used to evaluate the cytocompatibility. It was revealed that a rough surface with densely porous double layer composed of TiO2/CuO/Cu2O was produced on Ti-Cu alloy surface after the combined surface modification, which enhanced the corrosion resistance significantly. The plate counting results demonstrated that the modified sample had strong long-term antibacterial performance (antibacterial rate > 99%), which was attributed to the formation of TiO2/CuO/Cu2O composite film. The cell compatibility evaluation results indicated that the surface modification improved the cytocompatibility. It was demonstrated that the combined modification provided very strong antibacterial ability and good cytocompatiblity, potentially making it a good candidate surface modification technique for Ti-Cu alloy for biomedical applications.

show abstract

“…Nevertheless, Ti64 alloy shows serious drawbacks such as poor wear resistance and low antibacterial activity, which may result in the early degradation of long-term prostheses [3]. To overcome these drawbacks, the addition of antibacterial metals such as silver and copper has been proposed [4][5][6][7][8][9][10][11][12]. It has been reported in [13,14] that a high level of antibacterial activity is reached with the addition of less than 5 wt% of Cu or Ag.…”

Section: Introductionmentioning

confidence: 99%

Powder Metallurgy Fabrication and Characterization of Ti6Al4V/xCu Alloys for Biomedical Applications

Vergara–Hernández

Olmos

Solorio

et al. 2023

Metals

View full text Add to dashboard Cite

Ti6Al4V (Ti64) alloy is the most used metal material for bone implants because of its good biocompatibility and adapted mechanical properties. Nevertheless, it shows low antibacterial activity, which may favor its failure. Addition of antibacterial elements such as copper should avoid this drawback. This work studies the addition of Cu into a Ti64 matrix resulting in Ti64/xCu composites. Powder mixtures of Ti64/xCu were compacted in a die and then sintered at 1100 °C. Sintering kinetics indicate that densification is achieved by pore filling due to eutectic liquid formed by the reaction of Ti and Cu. The microstructure of the sintered samples is composed mainly of α-Ti and Ti2Cu phases, but TixCuy intermetallics were also found. Microhardness is increased by the addition of Cu due to densification and the formation of harder phases such as Ti2Cu. However, the stiffness and compression strength are barely the same for all composites. The corrosion resistance is significantly improved by the addition of Cu. Finally, the material with 15 wt% of copper showed the best compromise.

show abstract

Construction of a Rough Surface with Submicron Ti2Cu Particle on Ti-Cu Alloy and Its Effect on the Antibacterial Properties and Cell Biocompatibility

Cited by 6 publications

References 36 publications

Antibacterial Ti–Cu implants: A critical review on mechanisms of action

Antibacterial Ti–Cu implants: A critical review on mechanisms of action

Enhancing the Antibacterial Properties and Biocompatibility of Ti-Cu Alloy by Roughening and Anodic Oxidation

Powder Metallurgy Fabrication and Characterization of Ti6Al4V/xCu Alloys for Biomedical Applications

Contact Info

Product

Resources

About