Construction of a hollow MOF with high sedimentation performance and co-immobilization of multiple-enzymes for preparing rare ginsenoside CK

Cao, Shanshan; Li, Runze; Tian, Fei; Liu, Xiaochen; Fan, Daidi; Wu, Zhansheng

doi:10.1039/d3re00294b

Cited by 4 publications

(1 citation statement)

References 73 publications

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“…Using Sna&β-Glu@H-Cu-BDC (large-sized snailase&β-glucosidase@hollow-Cu-H2BDC) biocomposite for the synthesis of the CK. Cau et al [ 62 ] reported that the total amount of CK was about 0.94 mg mL −1 , and the average conversion rate of CK was around 60.12% after growing the conversion system.…”

Section: Biotransformation Of Ckmentioning

confidence: 99%

Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases

Morshed,

Akter,

Karim

et al. 2024

CIMB

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Rare ginsenoside compound K (CK) is an intestinal microbial metabolite with a low natural abundance that is primarily produced by physicochemical processing, side chain modification, or metabolic transformation in the gut. Moreover, CK exhibits potent biological activity compared to primary ginsenosides, which has raised concerns in the field of ginseng research and development, as well as ginsenoside-related dietary supplements and natural products. Ginsenosides Rb1, Rb2, and Rc are generally used as a substrate to generate CK via several bioconversion processes. Current research shows that CK has a wide range of pharmacological actions, including boosting osteogenesis, lipid and glucose metabolism, lipid oxidation, insulin resistance, and anti-inflammatory and anti-apoptosis properties. Further research on the bioavailability and toxicology of CK can advance its medicinal application. The purpose of this review is to lay the groundwork for future clinical studies and the development of CK as a therapy for metabolic disorders. Furthermore, the toxicology and pharmacology of CK are investigated as well in this review. The findings indicate that CK primarily modulates signaling pathways associated with AMPK, SIRT1, PPARs, WNTs, and NF-kB. It also demonstrates a positive therapeutic effect of CK on non-alcoholic fatty liver disease (NAFLD), obesity, hyperlipidemia, diabetes, and its complications, as well as osteoporosis. Additionally, the analogues of CK showed more bioavailability, less toxicity, and more efficacy against disease states. Enhancing bioavailability and regulating hazardous variables are crucial for its use in clinical trials.

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Section: Biotransformation Of Ckmentioning

confidence: 99%

Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases

Morshed,

Akter,

Karim

et al. 2024

CIMB

View full text Add to dashboard Cite

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Enzyme Conjugation - A Promising Tool for Bio-catalytic and Biotransformation Applications – A Review

Muneer,

Fatima,

Hussain

et al. 2024

Top Catal

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Study on synthesis of rare ginsenoside Rh2 by one-step purification and immobilization of glycosyltransferase from magnetic Ni-based MOF

Yue,

Liu,

et al. 2024

Molecular Catalysis

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Construction of a hollow MOF with high sedimentation performance and co-immobilization of multiple-enzymes for preparing rare ginsenoside CK

Abstract: Good catalytic performance and cycling stability are essential guarantees for the industrial application of immobilized enzyme. Protein-induced soft template method was used to prepare large-sized snailase&β-glucosidase@hollow-Cu-H2BDC (Sna&β-G@H-Cu-BDC) biocomposite for production...

Cited by 4 publications

References 73 publications

Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases

Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases

Enzyme Conjugation - A Promising Tool for Bio-catalytic and Biotransformation Applications – A Review

Study on synthesis of rare ginsenoside Rh2 by one-step purification and immobilization of glycosyltransferase from magnetic Ni-based MOF

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