2011
DOI: 10.1038/pj.2011.93
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Construction of a densely poly(ethylene glycol)-chain-tethered surface and its performance

Abstract: Non-biofouling surfaces constitute one of the most important subjects in sensitively and selectively detecting biomolecular events. Poly(ethylene glycol) (PEG) chains tethered on substrate surfaces are well known to reduce non-biofouling characteristics. Protein adsorption onto a PEG-chain-tethered surface is strongly influenced by the density of the PEG chain and is almost completely suppressed by the successive treatment of longer PEG chains (5 kDa) followed by the treatment of PEG (2 kDa; mixed-PEG-chain-te… Show more

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Cited by 114 publications
(109 citation statements)
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References 80 publications
(95 reference statements)
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“…PEGmodified surfaces have a low interfacial free energy in aqueous medium, as well as high chain mobility. The high chain mobility produces an excluded-volume effect [6] and reduces non-specific interactions with biomolecules. [7][8][9] Poly(MPC-co-butyl methacrylate) (PMB) adsorbs phospholipids in plasma.…”
Section: Introductionmentioning
confidence: 99%
“…PEGmodified surfaces have a low interfacial free energy in aqueous medium, as well as high chain mobility. The high chain mobility produces an excluded-volume effect [6] and reduces non-specific interactions with biomolecules. [7][8][9] Poly(MPC-co-butyl methacrylate) (PMB) adsorbs phospholipids in plasma.…”
Section: Introductionmentioning
confidence: 99%
“…Notably, this non-specific binding can be due to electrostatic interactions between biomolecules and the sensing surface [5]. Although adjusting the buffer conditions, pH, and/or salt concentration in the assay medium can favour reduced bio-fouling, it does not completely remove non-specific binding.…”
Section: Resultsmentioning
confidence: 98%
“…However, the quality of a given sensor is determined by its level of sensitivity and specificity [4], which can be dependent on the degree of biological non-specificity of the sensing surfaces (bio-fouling). Thus, proper substrate selection, along with fine-tuning of hydrophobicity/hydrophilicity and other factors influencing interactions on sensing surfaces, can significantly alter bio-fouling to enhance the reliability of biosensors [5].…”
Section: Introductionmentioning
confidence: 99%
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“…For fulfilling this criterion, a relatively simple and quick method was developed for building up the surface structure in Fig. 1 [17][18][19][20]. Moreover, the polyvalent effect of the cationic PAMA segment in PEG-b-PAMA on the negative charged YPO 4 NPs surface was anticipated.…”
Section: Introductionmentioning
confidence: 99%