Construction of a competitive electrochemical immunosensor based on sacrifice of Prussian blue and its ultrasensitive detection of alpha-fetoprotein

Wang, Min; Jiang, Mingzhe; Li, Pengli; Yuan, Meini; Zhao, Chulei; Lai, Wenjing; Li, Jiajia; Hong, Chenglin; Qi, Yu

doi:10.1016/j.aca.2023.341143

Cited by 8 publications

(3 citation statements)

References 34 publications

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“…As shown in Figure B, the presence of Au-rGO increases the intensity of the response current values compared to MB-SA/GCE. The stability exhibited at the same time ensures the accuracy of the test results . Subsequently, the EIS of Au-rGO/MB-SA/GCE before and after the dropwise addition of the mixed solution was tested to illustrate the suppression of the electrical signal by the resulting nonconductive polymer, as shown in Figure C.…”

Section: Results Discussionmentioning

confidence: 99%

“…The stability exhibited at the same time ensures the accuracy of the test results. 35 Subsequently, the EIS of Au-rGO/MB-SA/GCE before and after the dropwise addition of the mixed solution was tested to illustrate the suppression of the electrical signal by the resulting nonconductive polymer, as shown in Figure 5C. UV spectra were tested for the change in the absorbance of MB under different reaction conditions.…”

Section: ■ Introductionmentioning

confidence: 99%

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Construction of a Dual-Mode Immune Platform Based on the Photothermal Effect of AgCo@NC NPs for the Detection of α-Fetoprotein

Wang,

Jiang,

et al. 2023

Anal. Chem.

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Compared with the accuracy of a single signal and the limitation of environmental applicability, the application value of dual-mode detection is gradually increasing. To this end, based on the photothermal effect of Ag/Co embedded N-rich mesoporous carbon nanomaterials (AgCo@NC NPs), we designed a dual-mode signal response system for the detection of α-fetoprotein (AFP). First, AgCo@NC NPs act as a photothermal immunoprobe that converts light energy into heat driven by a near-infrared (NIR) laser and obtains temperature changes corresponding to the analyte concentration on a hand-held thermal imager. In addition, this temperature recognition system can significantly improve the efficiency of Fenton-like reactions. AgCo@NC NPs act as peroxidase mimics to initiate the generation of poly N-isopropylacrylamide (PNIPAM, resistance enhancer) by cascade catalysis and the degradation of methylene blue (MB), thus enabling electrochemical testing. The dual-mode assay ranges from 0.01 to 100 and 0.001−10 ng/mL, with lower limits of detection (LOD) of 3.2 and 0.089 pg/mL, respectively, and combines visualization, portability, and high efficiency, opening new avenues for future clinical diagnostics and inhibitor studies.

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Section: Results Discussionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Construction of a Dual-Mode Immune Platform Based on the Photothermal Effect of AgCo@NC NPs for the Detection of α-Fetoprotein

Wang,

Jiang,

et al. 2023

Anal. Chem.

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“…96 In recent times, some relevant electrochemical immunosensors have also been proposed with Prussian blue being included in the preparation, modification, and application. [97][98][99][100][101] Wang and co-workers reported that a composite of Prussian blue nanocube-decorated molybdenum disulfide possessed excellent electrocatalytic ability toward H 2 O 2 and was used in the design of a sensor for the label-free detection of carcinoembryonic antigen (CEA). Through the calculation of peak current changes in different medicated electrodes at 0.12 V, the ΔI of MoS 2 -PBNCs/GCE was 8.36-and 11.78-fold higher than that of the MoS 2 /GCE and PBNCs/GCE, respectively, resulting from the synergistic effect of MoS 2 and PBNCs.…”

Section: Prussian Blue Nanoparticlesmentioning

confidence: 99%