Construction of a biomimetic chemokine reservoir stimulates rapid in situ wound repair and regeneration

Xu, Xue‐Han; Yuan, Tiejun; Ye, Peiwu; Wang, Mao‐Ze; Ma, Hui-Jian; Jiang, Zhi‐Hong; Yong-pin, Zhang; Peng, Li‐Hua

doi:10.1016/j.ijpharm.2019.118648

Cited by 12 publications

(8 citation statements)

References 64 publications

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“…Skin cells in a low moisture environment, however, will significantly lower their vitality and even die . Accordingly, the use of wound dressings that are capable of keeping a wound moist has considered an effective strategy to promote wound healing and to reduce the formation of scars . Nonetheless, it should be noticed that an excessive level of moisture may lead to bacterial proliferation and the subsequent infection .…”

Section: Resultsmentioning

confidence: 99%

“…65 Accordingly, the use of wound dressings that are capable of keeping a wound moist has considered an effective strategy to promote wound healing and to reduce the formation of scars. 66 Nonetheless, it should be noticed that an excessive level of moisture may lead to bacterial proliferation and the subsequent infection. 67 Thus, how to confer the highly swelling NFMs with an antibacterial ability at the same time is of high importance for their uses in would healing dressings.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Preparation of Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes for Controlled Antibiotic Release

Chen

Liao

et al. 2020

Mol. Pharmaceutics

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Due to the cell affinity of chitosan (CS) and the hydrophilicity of polyethylene oxide (PEO), CS/PEO composited nanofiber meshes (NFMs) have been extensively used as wound healing dressings for skin tissue regeneration. Nonetheless, numerous innate drawbacks of the NFM system such as the use of toxic spinning solvents and cross-linkers, moderate water regain capacity, and lack of triggered release function significantly hampered their biomedical applications. In order to enhance their performances in promoting cell growth and preventing bacterial infection, highly swelling cross-linked N-maleoyl-functional chitosan (MCS)/PEO NFMs have been developed as the next-generation CS/PEO NFM system through an acid-free electrospinning process and a UV-irradiated cross-linked treatment without the use of aldehyde-containing cross-linkers. With the simultaneous introduction of ethylene oxide chains and disulfide bonds in the cross-linkages, this new NFM system displays enhanced swelling capability, antibacterial ability, triggered antibiotic release, and high biocompatibility. These biomedical merits enable the new NFM systems to be utilized as tissue scaffolds, especially for functional wound healing dressings.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Preparation of Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes for Controlled Antibiotic Release

Chen

Liao

et al. 2020

Mol. Pharmaceutics

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“…Xu et al. customized a biomimetic hydrogel utilizing PVA and CS as hybrid materials while loaded with chemotactic factor (SDF‐1) to stimulate a rapid in situ recruitment of bone marrow mesenchymal stem cells (BMSCs) for rapid wound repair and regeneration 113 . The doped chemokines can be consistently released from the hydrogel and significantly recruit BMSCs in vitro and in vivo.…”

Section: Sequestering Chemokinesmentioning

confidence: 99%

“…Xu et al customized a biomimetic hydrogel utilizing PVA and CS as hybrid materials while loaded with chemotactic factor (SDF-1) to stimulate a rapid in situ recruitment of bone marrow mesenchymal stem cells (BMSCs) for rapid wound repair and regeneration. 113 The doped chemokines can be consistently released from the hydrogel and significantly recruit BMSCs in vitro and in vivo. The hydrogel-based biomimetic PVA/CS hybrids for the local release of chemokines are a promising vehicle to improve healing outcomes without causing scar formation or any other adverse complications.…”

Section: F I G U R E 5 (A) P1 Reflects Global Charge Density Of Glyco...mentioning

confidence: 99%

Anti‐inflammatory hydrogel dressings and skin wound healing

Huang

Dong

Zhao

et al. 2022

Clinical & Translational Med

138

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Hydrogels are promising and widely utilized in the biomedical field. In recent years, the anti‐inflammatory function of hydrogel dressings has been significantly improved, addressing many clinical challenges presented in ongoing endeavours to promote wound healing. Wound healing is a cascaded and highly complex process, especially in chronic wounds, such as diabetic and severe burn wounds, in which adverse endogenous or exogenous factors can interfere with inflammatory regulation, leading to the disruption of the healing process. Although insufficient wound inflammation is uncommon, excessive inflammatory infiltration is an almost universal feature of chronic wounds, which impedes a histological repair of the wound in a predictable biological step and chronological order. Therefore, resolving excessive inflammation in wound healing is essential. In the past 5 years, extensive research has been conducted on hydrogel dressings to address excessive inflammation in wound healing, specifically by efficiently scavenging excessive free radicals, sequestering chemokines and promoting M1‐to‐M2 polarization of macrophages, thereby regulating inflammation and promoting wound healing. In this study, we introduced novel anti‐inflammatory hydrogel dressings and demonstrated innovative methods for their preparation and application to achieve enhanced healing. In addition, we summarize the most important properties required for wound healing and discuss our analysis of potential challenges yet to be addressed.

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“…Han et al found that the rapid transformation of macrophage phenotype from M1 to M2 and the rapid decline of the overall content of macrophage are beneficial for wound healing, which provided an important theoretical support for the use of biological dressings with antibacterial and anti-inflammatory effects for wound healing . Researchers have made a lot of attempts to promote wound healing, such as addition of growth factors and other biological agents into dressing carriers, − involvement in cellular signaling pathways associated with cell proliferation, − design of tissue engineering materials, , and preparation of nonbiodegradable materials, which are similar to the “biological glue” self-healing hydrogels. − In addition, a large number of studies have been focused on the development of multifunctional materials for wound healing. Satisfactory results were achieved at the cost of extraordinarily high price and complicated procession, which made them almost impossible to be widely adopted in clinical applications. − Therefore, the current situation of wound dressings prompts us to continue to explore: can we obtain the wound dressings that can accommodate the wound repair needs discussed above while also simplifying the ingredients and preparation scheme in next few years?…”

Section: Introductionmentioning

confidence: 99%

Ion-Excited Mechanically Active Self-Assembling Membranes for Rapid Wound Healing

Dong

Zhang

Yang

et al. 2021

ACS Appl. Bio Mater.

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Biodegradable hydrogels or membranes show great application potential in wound healing of skin tissue in recent years because of their excellent biocompatibility and healing promotion. However, poor mechanical properties and single biological properties are the main challenges that traditional hydrogels or membranes need to overcome, while some other hydrogels or membranes with excellent mechanical properties are still limited by complicated preparation processes and high cost as well as poor biological safety. Here, a kind of Na + /Ca 2+ -inspired layer by layer self-assembly membrane (LBLSM) with controlled deformation is prepared through a simple method. LBLSM showed excellent antibacterial ability and mechanical properties under conditions of no matter drying, water or ethanol, which facilitated LBLSM to maintain a stable state in the face of more complicated treatments. More interestingly, the controlled deformation of LBLSM could be achieved and precisely regulated by Na + /Ca 2+ alternative treatment, which helped the regular diastole and contraction of the wound, further effectively activating cellular proliferation and promoting rapid wound healing. In conclusion, ion-excited LBLSM provides a good demonstration and inspiration for the application of mechanically active biomaterials in wound healing.

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Construction of a biomimetic chemokine reservoir stimulates rapid in situ wound repair and regeneration

Cited by 12 publications

References 64 publications

Preparation of Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes for Controlled Antibiotic Release

Preparation of Highly Swelling/Antibacterial Cross-Linked N-Maleoyl-Functional Chitosan/Polyethylene Oxide Nanofiber Meshes for Controlled Antibiotic Release

Anti‐inflammatory hydrogel dressings and skin wound healing

Ion-Excited Mechanically Active Self-Assembling Membranes for Rapid Wound Healing

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