Construction of a 980 nm laser-activated Pt(II) metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization

Xu, Yuling; Li, Chonglu; An, Jusung; Ma, Xin; Yang, Jingfang; Luo, Li‐Shi; Deng, Yun; Kim, Jong Seung; Sun, Yao

doi:10.1007/s11426-022-1440-2

Cited by 84 publications

(35 citation statements)

References 50 publications

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“…The elevated expression of LGMN in TAMs of colorectal cancer tissue samples. Secondly, LGMN knockdown TAMs were shown to be able to prevent tumor growth in vivo by comparing the effects of LGMN overexpression TAMs and LGMN knockdown TAMs.The expression of angiogenic marker CD31 was significantly inhibited by immunohistochemistry ( Xu et al, 2022 ), and the expression of malignant growth marker Ki67 was down-regulated in TAM-related tumors inhibited by LGMN, suggesting that LGMN-inhibited TAM can reduce tumor growth and angiogenesis in vivo . In conclusion, reducing the amount of TAM in the tumor matrix can alter the tumor microenvironment, thus significantly inhibiting tumor growth and metastasis.…”

Section: Relationship Between Lgmn and Tumor Microenvironmentmentioning

confidence: 99%

Role of LGMN in tumor development and its progression and connection with the tumor microenvironment

Khan

Khan²,

Khan³

et al. 2023

Front. Mol. Biosci.

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Legumain (LGMN) has been demonstrated to be overexpressed not just in breast, prostatic, and liver tumor cells, but also in the macrophages that compose the tumor microenvironment. This supports the idea that LGMN is a pivotal protein in regulating tumor development, invasion, and dissemination. Targeting LGMN with siRNA or chemotherapeutic medicines and peptides can suppress cancer cell proliferation in culture and reduce tumor growth in vivo. Furthermore, legumain can be used as a marker for cancer detection and targeting due to its expression being significantly lower in normal cells compared to tumors or tumor-associated macrophages (TAMs). Tumor formation is influenced by aberrant expression of proteins and alterations in cellular architecture, but the tumor microenvironment is a crucial deciding factor. Legumain (LGMN) is an in vivo-active cysteine protease that catalyzes the degradation of numerous proteins. Its precise biological mechanism encompasses a number of routes, including effects on tumor-associated macrophage and neovascular endothelium in the tumor microenvironment. The purpose of this work is to establish a rationale for thoroughly investigating the function of LGMN in the tumor microenvironment and discovering novel tumor early diagnosis markers and therapeutic targets by reviewing the function of LGMN in tumor genesis and progression and its relationship with tumor milieu.

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Section: Relationship Between Lgmn and Tumor Microenvironmentmentioning

confidence: 99%

Role of LGMN in tumor development and its progression and connection with the tumor microenvironment

Khan

Khan²,

Khan³

et al. 2023

Front. Mol. Biosci.

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“…High-resolution images are highly desirable for precise diagnosis and accurate guidance for tumor treatment. Taking the advantages of high PCE and NIR-II fluorescence emission of M1 NPs, the in vivo PA and NIR-II fluorescence imaging was performed. − A strong PA and NIR-II fluorescence from the tumor regions are clearly observed in Figure A,B, respectively, after intratumoral injection of 4T1 tumor-bearing mice with M1 NP aqueous solution. Next, we evaluated the in vivo PTT efficacy of M1 NPs.…”

Section: Results and Discussionmentioning

confidence: 99%

Aggregation-Enhanced Photophysical Performance of D-π-A Structured Hemicyanine for NIR-II Fluorescent and Photoacoustic Imaging-Guided Photothermal Therapy

Pang

Zhao

et al. 2023

Chemical & Biomedical Imaging

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Near-infrared (NIR)-II fluorescence and photoacoustic (PA) dual-model imaging-guided photothermal therapy (PTT) can precisely diagnose and treat tumors and evaluate the therapeutic efficacy in real-time. Herein, we utilized a donor-π-acceptor (D-π-A) structured hemicyanine dye (named M1) with a large conjugated structure and strong intramolecular charge transfer effect and demonstrated that the aggregation of M1 could significantly enhance its photophysical performance by improving its photostability and photothermal conversion capability as compared with M1 in a single molecular state. Furthermore, we prepared water-dispersible NIR-II fluorescent nanoparticles (M1 NPs) by wrapping M1 with DSPE-PEG2000-NH2. The obtained M1 NPs exhibit strong NIR-I absorption and NIR-II fluorescence with their maxima at 734 and 1040 nm, respectively, with a fluorescence quantum yield of 2.84%. Moreover, M1 NPs also exhibit excellent biocompatibility, good photostability, and high photothermal conversion efficiency of 77.5%. In vitro and in vivo experiments reveal that M1 NPs can effectively image tumors through NIR-II fluorescence and PA signals, inhibit DNA replication, trigger cytoskeleton collapse, and eventually induce tumor cell apoptosis under 808 nm laser irradiation. Based on these outstanding properties, the application of M1 NPs in PA and NIR-II fluorescence imaging-guided PTT of tumors is demonstrated.

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“…[7][8][9][10][11][12] To date, various advanced PSs have been developed, but several obstacles impede their acceptance in biomedicine. [13][14][15][16] For example, PSs oen undergo p-p stacking, which reduces the singlet oxygen quantum yield. 17,18 Moreover, the inferior tissue penetration capability of the light sources currently used with PSs (<800 nm) reduces the PDT efficiency in deep-seated tumors.…”

Section: Introductionmentioning

confidence: 99%

Acceptor engineering of metallacycles with high phototoxicity indices for safe and effective photodynamic therapy

Yang

et al. 2023

Chem. Sci.

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Construction of a 980 nm laser-activated Pt(II) metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization

Cited by 84 publications

References 50 publications

Role of LGMN in tumor development and its progression and connection with the tumor microenvironment

Role of LGMN in tumor development and its progression and connection with the tumor microenvironment

Aggregation-Enhanced Photophysical Performance of D-π-A Structured Hemicyanine for NIR-II Fluorescent and Photoacoustic Imaging-Guided Photothermal Therapy

Acceptor engineering of metallacycles with high phototoxicity indices for safe and effective photodynamic therapy

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