Construction Methodology for NIUTS – Bed Servoing System for Body Targets –

Koizumi, Norihiro; Seo, Joonho; Funamoto, Takakazu; Itagaki, Yasushi; Nomiya, Akira; Ishikawa, Akira; Tsukihara, Hiroyuki; Yoshinaka, Kiyoshi; Sugita, Naohiko; Homma, Yukio; Matsumoto, Yoichiro; Mitsuishi, Mamoru

doi:10.20965/jrm.2013.p1088

Cited by 5 publications

(1 citation statement)

References 20 publications

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“…Therefore, bleedingassociated complications caused by needle puncture are absent. Hopefully, a Japanese corporation will develop a HIFU system that can ablate HCC lesions precisely within a shorter treatment time by utilizing new software, such as respiratory motion tracking [10]. The combination of HIFU with nano-bubbles containing anticancer drugs for the treatment of hepatic malignant lesions may prolong the overall survival of patients, especially patients with hepatic metastases from colon carcinoma.…”

mentioning

confidence: 99%

Advances in ultrasound systems for hepatic lesions in Japan

Numata

2015

J Med Ultrasonics

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mentioning

confidence: 99%

Advances in ultrasound systems for hepatic lesions in Japan

Numata

2015

J Med Ultrasonics

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Focused Ultrasound and Lithotripsy

Ikeda

Yoshizawa

Koizumi

et al. 2016

Advances in Experimental Medicine and Biology

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Shock wave lithotripsy has generally been a first choice for kidney stone removal. The shock wave lithotripter uses an order of microsecond pulse durations and up to a 100 MPa pressure spike triggered at approximately 0.5-2 Hz to fragment kidney stones through mechanical mechanisms. One important mechanism is cavitation. We proposed an alternative type of lithotripsy method that maximizes cavitation activity to disintegrate kidney stones using high-intensity focused ultrasound (HIFU). Here we outline the method according to the previously published literature (Matsumoto et al., Dynamics of bubble cloud in focused ultrasound. Proceedings of the second international symposium on therapeutic ultrasound, pp 290-299, 2002; Ikeda et al., Ultrasound Med Biol 32:1383-1397, 2006; Yoshizawa et al., Med Biol Eng Comput 47:851-860, 2009; Koizumi et al., A control framework for the non-invasive ultrasound the ragnostic system. Proceedings of 2009 IEEE/RSJ International Conference on Intelligent Robotics and Systems (IROS), pp 4511-4516, 2009; Koizumi et al., IEEE Trans Robot 25:522-538, 2009). Cavitation activity is highly unpredictable; thus, a precise control system is needed. The proposed method comprises three steps of control in kidney stone treatment. The first step is control of localized high pressure fluctuation on the stone. The second step is monitoring of cavitation activity and giving feedback on the optimized ultrasound conditions. The third step is stone tracking and precise ultrasound focusing on the stone. For the high pressure control we designed a two-frequency wave (cavitation control (C-C) waveform); a high frequency ultrasound pulse (1-4 MHz) to create a cavitation cloud, and a low frequency trailing pulse (0.5 MHz) following the high frequency pulse to force the cloud into collapse. High speed photography showed cavitation collapse on a kidney stone and shock wave emission from the cloud. We also conducted in-vitro erosion tests of model and natural kidney stones. For the model stones, the erosion rate of the C-C waveform showed a distinct advantage with the combined high and low frequency waves over either wave alone. For optimization of the high frequency ultrasound intensity, we investigated the relationship between subharmonic emission from cavitation bubbles and stone erosion volume. For stone tracking we have also developed a non-invasive ultrasound theragnostic system (NIUTS) that compensates for kidney motion. Natural stones were eroded and most of the resulting fragments were less than 1 mm in diameter. The small fragments were small enough to pass through the urethra. The results demonstrate that, with the precise control of cavitation activity, focused ultrasound has the potential to be used to develop a less invasive and more controllable lithotripsy system.

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