Construction and Validation of a Systematic Ethogram of Macaca fascicularis in a Free Enclosure

Xu, Fan; Xie, Liang; Li, Xin; Li, Qi; Wang, Tao; Ji, Yongjia; Kong, Fei; Zhan, Qunlin; Cheng, Ke; Fang, Liang; Xie, Peng

doi:10.1371/journal.pone.0037486

Cited by 21 publications

(27 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…25,[34][35][36] However, as a novel model species, the zebrafish has its own challenges. 17 For example, while rodent and primate behaviors have been comprehensively evaluated and defined, [37][38][39][40][41] zebrafish behavioral terminology is far less developed and consistent (see further). As Edwin Land famously noted, ''a problem well defined is half solved''.…”

mentioning

confidence: 99%

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

et al. 2013

View full text Add to dashboard Cite

Zebrafish (Danio rerio) are rapidly gaining popularity in translational neuroscience and behavioral research. Physiological similarity to mammals, ease of genetic manipulations, sensitivity to pharmacological and genetic factors, robust behavior, low cost, and potential for high-throughput screening contribute to the growing utility of zebrafish models in this field. Understanding zebrafish behavioral phenotypes provides important insights into neural pathways, physiological biomarkers, and genetic underpinnings of normal and pathological brain function. Novel zebrafish paradigms continue to appear with an encouraging pace, thus necessitating a consistent terminology and improved understanding of the behavioral repertoire. What can zebrafish 'do', and how does their altered brain function translate into behavioral actions? To help address these questions, we have developed a detailed catalog of zebrafish behaviors (Zebrafish Behavior Catalog, ZBC) that covers both larval and adult models. Representing a beginning of creating a more comprehensive ethogram of zebrafish behavior, this effort will improve interpretation of published findings, foster cross-species behavioral modeling, and encourage new groups to apply zebrafish neurobehavioral paradigms in their research. In addition, this glossary creates a framework for developing a zebrafish neurobehavioral ontology, ultimately to become part of a unified animal neurobehavioral ontology, which collectively will contribute to better integration of biological data within and across species.

show abstract

mentioning

confidence: 99%

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

et al. 2013

View full text Add to dashboard Cite

show abstract

“…[14] These behavioral items and categories have been applied in the current study. As to recording, all behavior was videotaped with one day of observation consisting of seven observational phases of 30 minutes each as follows: A2 10:00–10∶30, A3 10:30–11∶00, A4 11:00–11∶30, P2 14:30–15∶00, P3 15:00–15∶30, P4 15:30–16∶00, and P5 16:00–16∶30.…”

Section: Methodsmentioning

confidence: 99%

“…∧More detail behavioral items and categories established by systematic ethogram of M. fascicularis [14].…”

Section: Methodsmentioning

confidence: 99%

“…Our previous work constructed a systematic ethogram of the adult female cynomolgus monkey ( Macaca fascicularis) reared and observed in a social environment, demonstrating that these subjects were psychosocially mature. [14] Moreover, a few research groups have begun social isolation studies on adult female macaques, and these investigations have revealed depression-like characteristics (e.g., anhedonia, increased rates of submissive behaviors, and reduced hippocampal neurogenesis) in socially-isolated adult macaques. [15], [16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis

Xie

et al. 2013

PLoS ONE

Self Cite

View full text Add to dashboard Cite

Major depressive disorder (MDD) is a debilitating psychiatric mood disorder that affects millions of individuals globally. Our understanding of the biological basis of MDD is poor, and current treatments are ineffective in a significant proportion of cases. This current situation may relate to the dominant rodent animal models of depression, which possess translational limitations due to limited homologies with humans. Therefore, a more homologous primate model of depression is needed to advance investigation into the pathophysiological mechanisms underlying depression and to conduct pre-clinical therapeutic trials. Here, we report two convenient methods – social isolation and social plus visual isolation – which can be applied to construct a non-human primate model of depression in the adult female cynomolgus monkey (Macaca fascicularis). Both social and social plus visual isolation were shown to be effective in inducing depression-like behavior by significantly reducing socially dominant aggressive conflict behavior, communicative behavior, sexual behavior, and parental behavior. The addition of visual isolation produced more profound behavioral changes than social isolation alone by further reducing parental behavior and sexual behavior. Thus, the degree of behavioral pathology may be manipulated by the degree of isolation. These methods can be applied to construct a non-human primate model of depression in order to assess physiological, behavioral, and social phenomena in a controlled laboratory setting.

show abstract

“…According to Son (2004), long-tailed macaques spend around 2.5 % of their time in "other activities," including play behavior. Xu et al (2012) reported that play behaviors occurred at a lower average daily count per subject (1.22, i.e., 0.20% of the total behaviors expressed by macaque) compared to other behaviors. In addition, in rhesus macaques, play is also a minor activity, representing around 5% of the group activities (Bernstein & Mason, 1963;Post & Baulu, 1978), or less (1.13%, Fisler, 1967).…”

Section: Is Adult Play Triggered By Intensive Captive Conditions?mentioning

confidence: 98%

Animal Welfare: Could Adult Play be a False Friend?

Blois‐Heulin¹,

Rochais²,

Camus³

et al. 2015

AB&C

View full text Add to dashboard Cite

-There is no consensus regarding the functions of play. As play behavior is a characteristic of young stages of development, it has been suggested that the higher prevalence of adult play observed in domestic animals could be the result of their "neotenic retardation." Functional hypotheses have dealt with the long term benefits, such as "rehearsal," "motor training" for future adult competencies or "training for the unexpected." However, there is little consistent experimental evidence favoring a particular hypothesis. The present study aimed to test the functional significance of adult play as a potential reliable indicator of good welfare, a by-product of domestication or a tool for social cohesion. Observations of both a domestic species (the horse) and wild/captive animals (cercopithecids) confirm the literature data that show the greater prevalence of adult play in the domestic/captive situations. This convergence between a domestic and a wild species argue against the idea that adult play may be a mere product of domestication. Moreover, animals living in naturalistic situations had the same low level of adult play as observed in wild animals suggesting that captive/domestic animals do not play only because they are stress free or well fed. Play is not a reliable indicator of welfare: Horses and adult macaques that played the most were also those that exhibited the greatest signals of poor welfare as stereotypic behaviors. Furthermore, adult play was more frequent at times of social disturbances and instability. Adult play is a sign showing that the adult organism needs to evacuate stress.

show abstract

Construction and Validation of a Systematic Ethogram of Macaca fascicularis in a Free Enclosure

Cited by 21 publications

References 15 publications

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

Depression-Like Behavioral Phenotypes by Social and Social Plus Visual Isolation in the Adult Female Macaca fascicularis

Animal Welfare: Could Adult Play be a False Friend?

Contact Info

Product

Resources

About