Construction and evaluation of novel αvβ3 integrin ligand-conjugated ultrasmall star polymer micelles targeted glomerular podocytes through GFB permeation

Huang, Chengyuan; Zhao, Xuan; Su, Meiling; Yin, Zongning

doi:10.1016/j.biomaterials.2021.121053

Cited by 9 publications

(5 citation statements)

References 59 publications

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“…However, no biomarker studies were reported to prove true podocyte localization. Huang et al coated a micelle with another integrin αvβ3‐specific binding peptide (Arg‐Try‐D‐Arg‐Asn‐Met, RWrNM); the results demonstrated higher uptake in the rat kidney compared with the micelle without the targeting peptide and showed the co‐localization of the micelle with nephrin‐expressing podocytes (C. Huang, Zhao, et al, 2021). However, this nanoparticle accumulated more in the liver than in the kidney and was not tested in a disease model.…”

Section: Targeting Of Nanoparticles To Kidneysmentioning

confidence: 99%

A quantitative review of nanotechnology‐based therapeutics for kidney diseases

Cheng,

Ngoc Ta,

Hsia

et al. 2024

WIREs Nanomed Nanobiotechnol

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Kidney‐specific nanocarriers offer a targeted approach to enhance therapeutic efficacy and reduce off‐target effects in renal treatments. The nanocarriers can achieve organ or cell specificity via passive targeting and active targeting mechanisms. Passive targeting capitalizes on the unique physiological traits of the kidney, with factors like particle size, charge, shape, and material properties enhancing organ specificity. Active targeting, on the other hand, achieves renal specificity through ligand‐receptor interactions, modifying nanocarriers with molecules, peptides, or antibodies for receptor‐mediated delivery. Nanotechnology‐enabled therapy targets diseased kidney tissue by modulating podocytes and immune cells to reduce inflammation and enhance tissue repair, or by inhibiting myofibroblast differentiation to mitigate renal fibrosis. This review summarizes the current reports of the drug delivery systems that have been tested in vivo, identifies the nanocarriers that may preferentially accumulate in the kidney, and quantitatively compares the efficacy of various cargo‐carrier combinations to outline optimal strategies and future research directions.This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Section: Targeting Of Nanoparticles To Kidneysmentioning

confidence: 99%

A quantitative review of nanotechnology‐based therapeutics for kidney diseases

Cheng,

Ngoc Ta,

Hsia

et al. 2024

WIREs Nanomed Nanobiotechnol

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“…34 The structure between the capillaries and the renal vesicles is called the filtration membrane and consists of three layers. 35,36 The first inner layer is the glomerular endothelium, 37 which has many pores with diameters within the range of 60-100 nm 1 . The second intermediate layer is the glomerular basement membrane with a reticular slit of about 10 nm, an acellular layer composed of heparan sulfate proteoglycans, type IV collagen, and laminin that affects filtration through mechanical and charge barriers.…”

Section: Kelong Aimentioning

confidence: 99%

Antioxidative 0-dimensional nanodrugs overcome obstacles in AKI antioxidant therapy

Yang¹,

Chen²,

Xiao³

et al. 2023

J. Mater. Chem. B

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“…It has been found that various physical, chemical, and biological methods, as well as the modification of various nanocomposites, will positively influence cell adhesion by imparting surface activity. [76] Liver cancer is currently treated primarily by surgical excision and ablation methods for many patients. There are, however, a relatively small percentage of patients suitable for this invasive procedure.…”

Section: Pcl-based Hydrogel-focusing Radiation Therapymentioning

confidence: 99%

Section: Polymeric Micelles For Synthesis Of Responsive Hydrogels In ...mentioning

confidence: 99%