“…Although not statistically significant, trends have also been reported as favouring children with cortical ⁄ subcortical lesions compared to those with periventricular white matter lesions. 1 In this issue, the paper by Kuhnke et al exploring the impact of different types of corticospinal (re)organization on CIMT outcomes, adds important information about children's responses to uni-manual upper limb intervention. This study is limited by the small sample size, broad age range, and uni-manual rather than bimanual outcome measure.…”