Constraining ultralight bosonic dark matter with Keck observations of S2’s orbit and kinematics

Yuan, Guan-Wen; Shen, Zhao-Qiang; Tsai, Yue-Lin Sming; Yuan, Qiang; Fan, Yi‐Zhong

doi:10.1103/physrevd.106.103024

Cited by 18 publications

(13 citation statements)

References 99 publications

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“…[ 113c ] Deoxy‐sugar inducing VEGF production, thereby preventing the direct delivery of VEGF. [ 250 ] In addition, drugs such as DFO, [ 23a‐j,251 ] paeoniflorin, [ 33b ] and simvastatin, [ 70a ] have been used in the treatment diabetic wounds, and they overcome these shortcomings to some extent. It has been reported that DFO can stabilize the HIF‐1α, thereby promoting the secretion of VEGF and SDF‐1, and then facilitating vascularization.…”

Section: Application Of Hydrogel For Diabetic Wound Healingmentioning

confidence: 99%

Multifunctional Hydrogels for the Healing of Diabetic Wounds

Xiang,

Guo,

Jia

et al. 2023

Adv Healthcare Materials

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The healing of diabetic wounds is hindered by various factors, including bacterial infection, macrophage dysfunction, excess proinflammatory cytokines, high levels of reactive oxygen species, and sustained hypoxia. These factors collectively impede cellular behaviors and the healing process. Consequently, this review presents intelligent hydrogels equipped with multifunctional capacities, which enable them to dynamically respond to the microenvironment and accelerate wound healing in various ways, including stimuli ‐responsiveness, injectable self‐healing, shape ‐memory, and conductive and real‐time monitoring properties. The relationship between the multiple functions and wound healing is also discussed. Based on the microenvironment of diabetic wounds, antibacterial, anti‐inflammatory, immunomodulatory, antioxidant, and pro‐angiogenic strategies are combined with multifunctional hydrogels. The application of multifunctional hydrogels in the repair of diabetic wounds is systematically discussed, aiming to provide guidelines for fabricating hydrogels for diabetic wound healing and exploring the role of intelligent hydrogels in the therapeutic processes.

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Section: Application Of Hydrogel For Diabetic Wound Healingmentioning

confidence: 99%

Multifunctional Hydrogels for the Healing of Diabetic Wounds

Xiang,

Guo,

Jia

et al. 2023

Adv Healthcare Materials

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“…[ 5 ] Current conventional treatments cannot provide a complete solution to ulcer problems faced by patients with advanced diabetes; therefore, many new treatments are being developed. These include photothermal, [ 6 ] oxygen release, [ 7 ] wound dressing, and engineered stem cell‐based therapies. [ 8 ] Among these, wound dressings containing advanced hydrogels with extracellular matrix‐like structures have recently been developed and are widely used to repair various skin defects.…”

Section: Introductionmentioning

confidence: 99%

Glycopeptide‐Based Multifunctional Hydrogels Promote Diabetic Wound Healing through pH Regulation of Microenvironment

Xia

Dong

Tang

et al. 2023

Adv Funct Materials

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Excessive inflammation, bacterial infection, and blocked angiogenesis make diabetic wound healing challenging. Multifunctional wound dressings have several advantages in diabetic wound healing. In addition, the pH regulation of the microenvironment is shown to be a key factor that promotes skin regeneration through cellular immune regulation. However, few reports have focused on the development of functional dressings with the ability to regulate the pH microenvironment and promote diabetic wound healing. This study presents a novel approach for regulating the pH microenvironment of diabetic wound sites using a glycopeptide-based hydrogel consisting of modified hyaluronic acid and poly(6-aminocaproic acid). This hydrogel forms a network through Schiff base interactions and metal complexation, which suppresses inflammation and accelerates angiogenesis during wound healing. Hydrogels not only have adequate mechanical properties and self-healing ability but can also support tissue adhesion. They can also promote the secretion of inducible cAMP early repressor, which promotes the polarization of macrophages toward the M2 type. The in vivo results confirm that hydrogel promotes diabetic wound repair and skin regeneration by exerting rapid antiinflammatory effects and promoting angiogenesis. Therefore, this hydrogel system represents an effective strategy for treating diabetic wounds.

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“…Infrared observations of stellar orbits in the vicinity of Sgr A * spanning nearly three decades have demonstrated the presence of a massive black hole in the Galactic center (e.g., Ghez et al 2008;Genzel et al 2010). These observations can also probe the mass distribution in the inner parsec, including that of the dark matter and other unseen material (Lacroix 2018;Nampalliwar et al 2021;Heißel et al 2022;Yuan et al 2022). The infrared astrometry has historically relied on a radio-based astrometric reference frame that ties IR-bright stars to the location of Sgr A * via simultaneous observation of SiO maseremitting stars and the Sgr A * 43 GHz radio continuum (e.g., Menten et al 1997;Reid et al 2003Reid et al , 2007Yelda et al 2010;Plewa et al 2015;Sakai et al 2019).…”

Section: Introductionmentioning

confidence: 99%

An Updated Reference Frame for the Galactic Inner Parsec

Darling,

Paine,

Reid

et al. 2023

ApJ

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Infrared observations of stellar orbits about Sgr A* probe the mass distribution in the inner parsec of the Galaxy and provide definitive evidence for the existence of a massive black hole. However, the infrared astrometry is relative and is tied to the radio emission from Sgr A* using stellar SiO masers that coincide with infrared-bright stars. To support and improve this two-step astrometry, we present new astrometric observations of 15 stellar SiO masers within 2 pc of Sgr A*. Combined with legacy observations spanning 25.8 yr, we reanalyze the relative offsets of these masers from Sgr A* and measure positions and proper motions that are significantly improved compared to the previously published reference frame. Maser positions are corrected for epoch-specific differential aberration, precession, nutation, and solar gravitational deflection. Omitting the supergiant IRS 7, the mean position uncertainties are 0.46 mas and 0.84 mas in R.A. and decl., and the mean proper motion uncertainties are 0.07 mas yr−1 and 0.12 mas yr−1, respectively. At a distance of 8.2 kpc, these correspond to position uncertainties of 3.7 and 6.9 au and proper motion uncertainties of 2.7 and 4.6 km s−1. The reference frame stability, the uncertainty in the variance-weighted mean proper motion of the maser ensemble, is 8 μas yr−1 (0.30 km s−1) in R.A. and 11 μas yr−1 (0.44 km s−1) in decl., which represents a 2.3-fold improvement over previous work and a new benchmark for the maser-based reference frame.

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Constraining ultralight bosonic dark matter with Keck observations of S2’s orbit and kinematics

Cited by 18 publications

References 99 publications

Multifunctional Hydrogels for the Healing of Diabetic Wounds

Multifunctional Hydrogels for the Healing of Diabetic Wounds

Glycopeptide‐Based Multifunctional Hydrogels Promote Diabetic Wound Healing through pH Regulation of Microenvironment

An Updated Reference Frame for the Galactic Inner Parsec

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