Constitutive activation of the ERK‐MAPK pathway in the suprachiasmatic nuclei inhibits circadian resetting

Hainich, Ernesto C.; Pizzio, Gastón A.; Golombék, Diego A.

doi:10.1016/j.febslet.2006.11.019

Cited by 15 publications

(16 citation statements)

References 30 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…pERK has been shown to play an important role in phase shifting after light pulses [42], [43], and it is one of the first elements in the SCN photic signaling pathway to be activated [44], [45]. cFos gene is upregulated in response to light pulses [46], and is commonly used as a marker of photic activation in the SCN.…”

Section: Resultsmentioning

confidence: 99%

Programming of Mice Circadian Photic Responses by Postnatal Light Environment

2014

View full text Add to dashboard Cite

Early life programming has important consequences for future health and wellbeing. A key new aspect is the impact of perinatal light on the circadian system. Postnatal light environment will program circadian behavior, together with cell morphology and clock gene function within the suprachiasmatic nucleus (SCN) of the hypothalamus, the principal circadian clock in mammals. Nevertheless, it is still not clear whether the observed changes reflect a processing of an altered photic input from the retina, rather than an imprinting of the intrinsic molecular clock mechanisms. Here, we addressed the issue by systematically probing the mouse circadian system at various levels. Firstly, we used electroretinography, pupillometry and histology protocols to show that gross retinal function and morphology in the adult are largely independent of postnatal light experiences that modulate circadian photosensitivity. Secondly, we used circadian activity protocols to show that only the animal's behavioral responses to chronic light exposure, but not to constant darkness or the acute responses to a light stimulus depend on postnatal light experience. Thirdly, we used real-time PER2::LUC rhythm recording to show long-term changes in clock gene expression in the SCN, but also heart, lung and spleen. The data showed that perinatal light mainly targets the long-term adaptive responses of the circadian clock to environmental light, rather than the retina or intrinsic clock mechanisms. Finally, we found long-term effects on circadian peripheral clocks, suggesting far-reaching consequences for the animal's overall physiology.

show abstract

Section: Resultsmentioning

confidence: 99%

Programming of Mice Circadian Photic Responses by Postnatal Light Environment

2014

View full text Add to dashboard Cite

show abstract

“…Certainly there are interactions of this signaling pathway and cocaine reward and recent work has implicated markers within this pathway as underlying long-term changes that are associated with the development of cocaine addiction (i.e., Egr1/NGFI-A/Zif268; MAPK phosphatases; for review see Lu et al 2006). Evidence of interaction of the ERK/MAPK signaling pathway with the circadian system also exists (i.e., Hainich et al 2006), and in fact, our present findings have revealed a number of changes in circadian associated genes within this signaling pathway (i.e., MAPK14/p38, Egr1/NGFI-A/Zif268, NGFI-B/Nur77, Lrrn3, JunD1, Fgf7, Kiss1r), as well as several other genes that do not have documented circadian interaction (i.e., Pdgfra, Znf322).…”

Section: Discussionmentioning

confidence: 99%

Gene profiling the response to repeated cocaine self-administration in dorsal striatum: A focus on circadian genes

et al. 2008

View full text Add to dashboard Cite

Alterations in gene expression in the dorsal striatum caused by chronic cocaine exposure have been implicated in the long-term behavioral changes associated with cocaine addiction. To gain further insight into the molecular alterations that occur as a result of cocaine self-administration, we conducted a microarray analysis of gene expression followed by bioinformatic gene network analysis that allowed us to identify adaptations at the level of gene expression as well as into interconnected networks. Changes in gene expression were examined in the dorsal striatum of rats 1 day after they had self-administered cocaine for 7 days under a 24-hr access, discrete trial paradigm (averaging 98 mg/kg/day). Here we report the regulation of the circadian genes Clock, Bmal1, Cryptochrome1, Period2, as well as several genes that are regulated by/associated with the circadian system (i.e., early growth response 1, dynorphin). We also observed regulation of other relevant genes (i.e., Nur77, beta catenin). These changes were then linked to curated pathways and formulated networks which identified circadian rhythm processes as affected by cocaine self-administration. These data strongly suggest involvement of circadian-associated genes in the brain's response to cocaine and may contribute to an understanding of addictive behavior including disruptions in sleep and circadian rhythmicity. Classification Molecular Brain Research SectionDisease-Related Neuroscience

show abstract

“…It is well established that MAPKs play a key role in photic circadian entrainment (Coogan and Piggins 2003;Coogan and Piggins 2004;Hainich et al 2006). However, the pathways for activation and inactivation of these kinases remained unresolved.…”

Section: Discussionmentioning

confidence: 99%

“…The activity of the three classical MAPKs (ERK, JNK, p38) shows a circadian oscillation in the SCN which is controlled by light (Pizzio et al 2003). In addition, pharmacological inhibition of ERK in the SCN produces an attenuation of photic-induced phase shifts of locomotor activity rhythms (Coogan et al 2003), and the sustained activation of ERK by a mutant MEK protein with constant and high ERK kinase activity also inhibits light-induced phase shifts (Hainich et al 2006). ERK can be activated by other stimuli that also affect the clock, such as nerve growth factor (NGF; Pizzio et al 2005), pituitary-adenylate cyclase-activating polypeptide (PACAP; Butcher et al 2005), epidermal growth factor (EGF; Hao et al 2006) or gastrin-releasing peptide (GRP; .…”

Section: Introductionmentioning

confidence: 99%

Photic Regulation of Map Kinase Phosphatases MKP1/2 and MKP3 in the Hamster Suprachiasmatic Nuclei

Pizzio

Golombék

2007

J Mol Neurosci

Self Cite

View full text Add to dashboard Cite

MAP kinases (MAPKs) play a key role in photic entrainment signaling in the suprachiasmatic nuclei (SCN), the mammalian circadian clock. The control of MAPKs is a fine balance between specific kinases (MEKs) and phosphatases (MKPs), whose orchestration in the SCN is still unresolved. We have found MKP1/2 and MKP3 immunoreactive-cells in the hamster SCN, whose levels are rapidly increased in response to transient light stimulation in the subjective night (CT 18), when light is able to entrain the clock. Moreover, the expression level of MKP3 varies under light-dark cycles and constant darkness, peaking at noon, when MAPKs are in their activated state and begin their inactivation. These results show a different perspective on MAPKs in the SCN, which includes its regulation by a complex net of phosphatases.

show abstract

Constitutive activation of the ERK‐MAPK pathway in the suprachiasmatic nuclei inhibits circadian resetting

Cited by 15 publications

References 30 publications

Programming of Mice Circadian Photic Responses by Postnatal Light Environment

Programming of Mice Circadian Photic Responses by Postnatal Light Environment

Gene profiling the response to repeated cocaine self-administration in dorsal striatum: A focus on circadian genes

Photic Regulation of Map Kinase Phosphatases MKP1/2 and MKP3 in the Hamster Suprachiasmatic Nuclei

Contact Info

Product

Resources

About