Constitution of Samidin, Dihydrosamidin and Visnadin¹

In vivo and in vitro anti-obesity activities of dihydropyranocoumarins derivatives from Peucedanum japonicum Thunb

“…Although several studies reported some pharmacological activities of PJT (Adams et al, 2009;Chen et al, 1996;Hisamoto et al, 2004;Lee et al, 2004;Takeuchi et al, 1991;Yang et al, 2009) and biological activities of pyranocoumarins (Call & Fischer, 1958;Nikonov et al, 1971;Smith et al, 1957;Thastrup et al, 1983), we demonstrated the anti-obesity activities of PJT and identified PTX as one of its active compound for the first time (Nugara et al, 2014;Okabe et al, 2011). Indeed, mice that were fed an HFDcontaining CC prepared from PJT-PTX (+) gained significantly lesser weight and had lower relative WAT weights than the control mice ( Fig.…”

“…The importance of acyloxy groups in positions R 1 and R 2 (Fig. 3A) have been reported in several bioactivities of dihydropyranocoumarins, and diacyloxy derivatives containing one fivecarbon acyloxy group have particularly shown strong activities (Call & Fischer, 1958;Nikonov et al, 1971;Smith et al, 1957;Thastrup et al, 1983). To elucidate the importance of the side chains of dihydropyranocoumairn for their anti-obesity effects, 3T3-L1 adipocytes were treated with VIS, which were used as a reference standard on HPLC analyses.…”

“…Angular-type pyranocoumarins, such as PTX, isolated from Peucedanum plants have several physiological activities (Nikonov, Avramenko, & Sharova, 1971;Smith, Hosansky, Bywater, & van Tamelen, 1957;Thastrup, Fjalland, & Lemmich, 1983). Some types of pyranocoumarins, which are structurally analogous to PTX, possessed similar bioactivities but different potencies (Chen et al, 2008;Lee, Lee, Kim, & Bang, 2015;Thastrup et al, 1983).…”

Biosynthesis of Furanochromones

“…1) whose structure was determined by Spath and Cruber (2), but the similar compound visnagin (8) (3) is also highly active. The plant contains other furanochrornones (4), a dihydrofuranochromoaae, visamminol (6) (5,6), and several vasodilatory coumarin derivatives (7).…”

Volatile constituents of Dorema aucheri Boiss., Seseli libanotis (L.) W. D. Koch var. armeniacum Bordz. and Conium maculatum L. three Umbelliferae herbs growing wild in Iran

“…It has been shown to be a rich source of coumarins, 13,14 in particular diesters of (+)-cis-khellactone, well-known for their properties as coronary vasodilators. 15,16 Three new sulfate ester salts derived from known coumarin alcohols, one of them tertiary, have been obtained from roots of Seseli libanotis subsp. eu-Libanotis.…”