Constitution and synthesis of endocrocin

Joshi, B.S.; Ramanathan, Surash; Венкатараман, К.

doi:10.1016/s0040-4039(00)70572-7

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…Unfortunately, these 7‐functionalized emodin derivatives turned out to be not suitable for the syntheses of 6,7‐bifunctional emodin derivatives due to their unsubstituted methyl group at C(6). The activation of this methyl group towards further oxidation seems to be rather hampered as a result of the additional electron‐withdrawing functional groups at C(7) as observed in our synthesis of endocrocin6 as well as by Joshi et al in their endocrocin synthesis starting from 6,7‐dimethyl emodin, where only the 7‐methyl group could be oxidized 9…”

Section: Resultsmentioning

confidence: 62%

Condensed Emodin Derivatives and Their Applicability for the Synthesis of a Fused Heterocyclic Hypericin Derivative

Waser

Falk

2006

Eur J Org Chem

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Investigations on the bifunctionalization of emodin at C(6) and C(7) with respect to the synthesis of a new class of fused heterocyclic hypericin derivatives were undertaken. The synthesis of such complex anthraquinone derivatives is possible by applying a Marschalk‐type reaction with emodin‐6‐carbaldehyde as the key step. The newly synthesized pyridazinone‐fused hypericin derivative possesses a satisfying bathochromically shifted absorption maximum making it a promising candidate for further investigations concerning a possible application in photodynamic therapy. Furthermore, the herein described strategy for the bifunctionalization of emodin provides a novel route for the synthesis of anthraquinone derivatives that are difficult to obtain by other methods.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)

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Section: Resultsmentioning

confidence: 62%