Constituents, Oxidant-Antioxidant Profile, and Antimicrobial Capacity of the Essential Oil Obtained from<i>Ferulago Sandrasica</i>Peşmen and Quézel

Çelik, Ali; Arslan, İdris; Herken, Emine Nur; Ermiş, A.

doi:10.1080/10942912.2011.618898

Cited by 25 publications

(9 citation statements)

References 22 publications

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“…Medical herbs are generally rich in phenolic compounds, such as phenolic acids, flavonoids, tannins, stilbenes, lignans, coumarins, and lignins (Celik et al. 2013 ). One of the therapeutic approach for treating diabetes is to reduce the postprandial hyperglycemia and this is made by delaying the absorption of glucose via the inhibition of the carbohydrate-hydrolyzing enzyme α-glucosidase in the digestive tract.…”

Section: Resultsmentioning

confidence: 99%

The α-amylase and α-glucosidase inhibitory activities of the dichloromethane extracts and constituents of Ferulago bracteata roots

Karakaya

Gözcü

Güvenalp

et al. 2017

Pharmaceutical Biology

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Context:Ferulago (Apiaceae) species have been used since ancient times for the treatment of intestinal worms, hemorrhoids, and as a tonic, digestive, aphrodisiac, or sedative, as well as in salads or as a spice due to their special odors.Objectives: This study reports the α-amylase and α-glucosidase inhibitory activities of dichloromethane extract and bioactive compounds isolated from Ferulago bracteata Boiss. & Hausskn. roots.Materials and methods: The isolated compounds obtained from dichloromethane extract of Ferulago bracteata roots through bioassay-guided fractionation and isolation process were evaluated for their in vitro α-amylase and α-glucosidase inhibitory activities at 5000–400 µg/mL concentrations. Compound structures were elucidated by detailed analyses (NMR and MS).Results: A new coumarin, peucedanol-2′-benzoate (1), along with nine known ones, osthole (2), imperatorin (3), bergapten (4), prantschimgin (5), grandivitinol (6), suberosin (7), xanthotoxin (8), felamidin (9), umbelliferone (10), and a sterol mixture consisted of stigmasterol (11), β-sitosterol (12) was isolated from the roots of F. bracteata. Felamidin and suberosin showed significant α-glucosidase inhibitory activity (IC50 0.42 and 0.89 mg/mL, respectively) when compared to the reference standard acarbose (IC50 4.95 mg/mL). However, none of the tested extracts were found to be active on α-amylase inhibition.Discussion and conclusions: The present study demonstrated that among the compounds isolated from CH2Cl2 fraction of F. bracteata roots, coumarins were determined as the main chemical constituents of this fraction. This is the first report on isolation and characterization of the bioactive compounds from root extracts of F. bracteata and on their α-amylase and α-glucosidase inhibitory activities.

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Section: Resultsmentioning

confidence: 99%

The α-amylase and α-glucosidase inhibitory activities of the dichloromethane extracts and constituents of Ferulago bracteata roots

Karakaya

Gözcü

Güvenalp

et al. 2017

Pharmaceutical Biology

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“…angulata exhibited no considerable biological activities. [46,47] The major components or their derivatives may also contribute to antimicrobial activity, thus it is still worthwhile to test the individual major components also against other pathogens in future works. As far as the mechanism of the antimicrobial activity is concerned, the complex and variable chemical composition of essential oils, which can include many different molecules, prevents the understanding of the mechanism of action.…”

Section: Disc Diffusion Methodsmentioning

confidence: 99%

Chemical composition, antibacterial and antifungal activities of seed essential oil of Ferulago angulata

Moghaddam

Mehdizadeh

Najafgholi

et al. 2018

International Journal of Food Properties

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The aim of this study was to determine the chemical composition and the in vitro antimicrobial effects of seed essential oil of Ferulago angulata. The oil analyses by GC and GC/MS resulted in the identification of 39 compounds representing 91.07% of the oil. The major constituents were (Z)-β-ocimene (19.93%), α-pinene (15.50%), p-cymene (7.67%), sabinene (7.49%), β-phellandrene (5.5%), and α-phellandrene (4.95%). The oil was also screened for its antimicrobial properties against six bacteria (Erwinia amylovora, Xanthomonas oryzae, Pseudomonas syringae, Pectobacterium carotovorum, Ralstonia solanacearum, Bacillus thuringiensis) and six fungi (Alternaria alternata, Culvularia fallax, Macrophomina phaseolina, Fusarium oxysporum, Cytospora sacchari, Colletotrichum tricbellum). According to the results of antibacterial activity, B. thuringiensis (with 8 µL mL −1 minimal inhibitory concentration (MIC) and 15 µL mL −1 minimum bactericidal concentration (MBC)) was the most sensitive bacterium; P. carotovorum and R. solanacearum (with 20 µL mL −1 MIC and 30< MBC) were the most resistant bacteria. Additionally, a broad differentiation against all of the tested fungi showed that the most susceptible and resistant fungi after 6 days at the highest concentration (800 µL L −1 ) were F. oxysporum (100.0 ± 0.00%) and C. tricbellum (52.50 ± 1.67%) of growth inhibition, respectively. ARTICLE HISTORY

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“…The essential oils of F. campestris were determined to have antioxidant and antifungal effects . The essential oils of F. sandrasica were also reported to have antibacterial and antioxidant activities with the emphasis that phenolic compounds may be responsible for the antioxidant activity . Moreover, F. angulata essential oil was determined to have antioxidant activities .…”

Section: Introductionmentioning

confidence: 99%

Anxiolytic and antidepressant‐like effects of Ferulago angulata essential oil in the scopolamine rat model of Alzheimer's disease

Bağcı

Aydin

Mihășan

et al. 2015

Flavour & Fragrance J

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Ferulago angulata subsp. carduchorum (Apiaceae) is a shrub indigenous to western Iran, Turkey and Iraq. In traditional medicine, F. angulata is recommended for treating digestive pains, haemorrhoids, snake bites, ulcers and as a sedative. The present study analysed the possible anxiolytic, antidepressant and antioxidant properties of F. angulata essential oil in a scopolamine‐induced rat model of Alzheimer's disease. The anxiolytic and antidepressant‐like effects of F. angulata essential oil were studied using in vivo (elevated plus‐maze and forced swimming tests) approaches. Also, the antioxidant activity in the amygdala was assessed using superoxide dismutase, glutathione peroxidase and catalase specific activities, the total content of the reduced glutathione, protein carbonyl and malondialdehyde levels. The scopolamine‐treated rats exhibited the following: a decrease in the percentage of the time spent and the number of entries in the open arm within the elevated plus‐maze test and a decrease of swimming time and an increase of immobility time in the forced swimming test. Inhalation of F. angulata essential oil significantly exhibited anxiolytic and antidepressant‐like effects and also antioxidant potential. Furthermore, in silico studies carried out by employing molecular docking experiments pointed to the existence of strong interactions of monoterpenes from F. angulata essential oil with anxiolytic and antidepressant effects with GABAA receptor. Our results suggest that the F. angulata essential oil inhalation ameliorates scopolamine‐induced anxiety and depression by attenuation of the oxidative stress in the rat amygdala. Copyright © 2015 John Wiley & Sons, Ltd.

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Constituents, Oxidant-Antioxidant Profile, and Antimicrobial Capacity of the Essential Oil Obtained fromFerulago SandrasicaPeşmen and Quézel

Cited by 25 publications

References 22 publications

The α-amylase and α-glucosidase inhibitory activities of the dichloromethane extracts and constituents of Ferulago bracteata roots

The α-amylase and α-glucosidase inhibitory activities of the dichloromethane extracts and constituents of Ferulago bracteata roots

Chemical composition, antibacterial and antifungal activities of seed essential oil of Ferulago angulata

Anxiolytic and antidepressant‐like effects of Ferulago angulata essential oil in the scopolamine rat model of Alzheimer's disease

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