Constituents of Machilus thunbergii bark and inhibition of cyclin-dependent kinases (CDKs) by procyanidin B2

Shrestha, Sabina; Park, Ji Hae; Lee, Dong Hoon; Cho, Jin Gyeong; Yoo, Jong Su; Yeon, Seung Woo; Kang, Hee Cheol; Baek, Nam In

doi:10.1007/bf03253192

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…In 2011, five sterols from the leafy culms of D. bipinnata were reported and identified as stigmasterol, β-sitosterol, daucosterol, stigmast-5-en-3β,7β-diol and stigmast-5-en-3β,7α-diol [22]. A new xanthene was isolated from methanolic extract, which was identified as 2,6-dihydroxy-7-methoxy-3H-xanthen-3-one ( Figure 1) [23]. In 2009, flavonoid compound 4'-methoxy quercetin-7-O-glucoside ( Figure 1) was isolated from methanolic extract [24].…”

Section: Phytochemical Constituentsmentioning

confidence: 99%

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et al. 2020

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The medicinal plant has been in perpetual use as a traditional medicine in most Asian and African countries. One such plant is Desmostachya bipinnata Linn., a perennial plant of Poaceae family, which has been widely used to treat some infectious diseases. The screening of this plant revealed substantial phytochemicals such as flavonoids, alkaloids, glycosides and other constituents, which possess a wide range of biological activities such as antiulcerogenic, anti-helicobacter, anti-inflammatory and other antimicrobial activity. The major compounds found in D. bipinnata are L-limonene, camphene, β-eudesmol, trycin-7-glucoside and trycin. So far, research on this plant demonstrated that, the isolated compounds are safe for human use. However, further activities of the phytochemicals and their medicinal aspects needs to be studied so that more new compounds can be identified, which can be used for the treatment of different bacterial infections. This review is an attempt to comprise all the study of plant phytochemical and antimicrobial properties.

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Section: Phytochemical Constituentsmentioning

confidence: 99%

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et al. 2020

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“…Some aurones with N-methylpiperidinyl at 7 position have been reported for inhibition of CDK1, CDK2 and CDK4 but not for CDK5/p25. 20 There are few natural products such as butyrolactone, 21 procyanidin B2, 22 hymenialdisine 23 and bellidin 24 that have been reported for CDK5/p25 inhibition. Recently, some effective CDK5/p25 inhibitory compounds including litvinolin, 6-O-galloyl arbutin, 4 0 -methoxyherbacetin, 6-O-galloyal arbutin, epigallocatechin-3-gallate, have been reported from Rhodiola rosea.…”

Section: Introductionmentioning

confidence: 98%