Constituents of Cassia laevigata

Constituents of the stem barks of Ailanthus altissima and their potential to inhibit LPS-induced nitric oxide production

“…The NMR data of 1 showed very similar feature to those of canthin-6-one except for the presence of two pendant sugar groups (a hexose and a pentose). The presence of a glucopyranosyl and an apiofuranosyl group in 1 was revealed by 1 H, 13 C, HMQC, MMBC, and NOESY NMR data analysis and by comparison with literature data. 19 An anomeric proton signal at δ H 5.46 (1H, d, J = 2.5 Hz), an anomeric carbon signal at δ C 109.4 (C-1"), a quaternary carbon signals at δ C 78.8 (C-3"), an oxymethine signal at δ C 76.1 (C-2"), and two oxymethylene signals at δ C 73.7 (C-4") and δ C 63.1 (C-5") were observed in the 1 H and 13 C NMR spectra, implicating an apiofuranosyl moieties in 1.…”

“…8 As a part of our ongoing project to search novel, plant-derived anti-inflammatory agents, a 70% EtOH extract of the stem barks of A. altissima was shown to exhibit significant inhibitory activity in a preliminary in vitro screening on LPS-induced nitric oxide, a pro-inflammatory mediator, in RAW 264.7 cells (IC 50 value of 23.84 µg/mL). Repeated chromatography of the EtOAc-and BuOH-soluble fractions from the stem barks of A. altissima led to the isolation of three new canthinone type alkaloids (1-3), along with twelve known compounds (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). 9 The structures of known compounds were identified to be shinjudilactone (4), 5 ailanthone (5), 5 shinjulactone A (6), 5 shinjuglycoside B (7), 10 4-hydroxybenzoic acid (8), 11 vanillic acid (9), 12 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-propan-1-one (10), 13 p-coumaric acid (11), 14 ferulic acid (12), 11 trans-4-O-β-D-glucopyranosyl ferulic acid (13), 15 isofraxidin (14), 16 Table 2).…”

Anti-Mayaro virus activity of Cassia australis extracts (Fabaceae, Leguminosae)

“…Due to the traditional use, several species, many already described in the literature, are medicinally used worldwide [15–20]. Cassia australis is a medium sized shrub and may reach up to 2.5 meters of diameter.…”

Inhibitory Effects of Phenylpropanoids Isolated from the Bark of Ailanthus altissima on COX-2 Activity

“…1). These compounds were identified as 3-hydroxy-1-(4-hydroxyphenyl)-propan-1-one (1), 12 p-coumaric acid (2), 13 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-propan-1-one (3), 14 2,3-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)-propan-1-one (4), 14 coniferyl alcohol (5), 15 and coniferyl aldehyde (6) 16 using physical and spectroscopic data (mp, 1 H-,…”

“…[12][13][14][15][16] To our knowledge, this is the first report to be issued on the isolation of phenylpropanoids 1, 3, and 4 from the genus Ailanthus. Plantderived phenylpropanoids compose the largest group of secondary metabolites produced by higher plants, and are mainly used for protection against biotic or abiotic stresses, such as, infections, wounding, UV radiation, exposure to 17 Some of these phenylpropanoids are considered to be biologically active and to have antibacterial, antiviral, analgesic, antispasmodic, neuroprotective, cytostatic, anti-inflammatory, and radical scavenging activities.…”