Constituents of Caesalpinia pyramidalis

Mendes, Carla C.; Bahia, Marcus Vinicius; David, Jorge; David, Juceni P.

doi:10.1016/s0367-326x(99)00145-8

Cited by 35 publications

(30 citation statements)

References 3 publications

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“…Phytochemical investigations have demonstrated the presence of secondary metabolites, such as flavonoids, diterpenes, tannins and lignans [6][7][8][9][10]. Several biological activities have already been tested with this species, among which we can highlight the antimicrobial activity against Staphylocus aureus, Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Salmonella spp., S. Aureus e Pseudomonas aeruginosa, antioxidant, gastro protective, anti-inflammatory, antinociceptive and anthelmintic activity, which corroborates many of its traditional uses.…”

Section: Introductionmentioning

confidence: 99%

Thermal Degradation Kinetics of Kaempferol and Quercetin in the Pre-Formulated of the Standardized Extracts of Poincianella Pyramidalis (Tul.) L. P. Queiroz Obtained by Spray Dryer

Oliveira

Leite

Dantas

et al. 2017

Int J Pharm Pharm Sci

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Objective: The aim of this work was to evaluate the stability and determine the kinetic parameters of degradation of biomarkers kaempferol and quercetin, present in the pre-formulated of the extract of Poincianella pyramidalis obtained by a spray dryer. Methods:A 2 3 experimental design coupled with RSM was applied to evaluate and optimize the effects of processing parameters on the content of chemical markers in dry extracts by a spray dryer. Stability testing was performed to verify the influence of temperature on the degradation of kaempferol and quercetin present in the pre-formulated. The markers contents were determined by HPLC.Results: Surface response analysis showed the influence of the independent variables on the responses of the concentration kaempferol and quercentin biomarkers on the process. The variables of the inlet air temperature, flow feed rate and the adjuvant ratio presented negative responses with significant difference (p<0.05). According to the data obtained in the stability of the pre-formulated studied zero and second orders kinetics models the for degradation of the kaempferol and only second order kinetic model for the quercetin. It was also evaluated reducing the concentration of both biomarkers studied throughout the study. Conclusion:In the present study, it was observed that all independent variables of the drying process by spray dryer showed the greatest influence on the concentration of the studied markers. Two markers had a different thermal behavior compared to the different excipients studied and there was degradation of both the quercentin biomarker and kaempferol during the study period.

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Section: Introductionmentioning

confidence: 99%

Thermal Degradation Kinetics of Kaempferol and Quercetin in the Pre-Formulated of the Standardized Extracts of Poincianella Pyramidalis (Tul.) L. P. Queiroz Obtained by Spray Dryer

Oliveira

Leite

Dantas

et al. 2017

Int J Pharm Pharm Sci

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“…LP Queiroz is an arboreal species of the Fabaceae family, popularly known as family. Lignans, gallic acid, steroids, phenylpropanoid, and tannins, flavonoids and especially biflavonoids are isolated in the leaves and stem of P. pyramidalis (Mendes et al, 2000;Bahia et al, 2005;Bahia et al, 2010;Oliveira, 2010). Monteiro (2005) quantified the greater abundance of metabolites in the methanol extract from the bark of catingueira, where he obtained 29.60 and 24.72 mg for total phenol and tannins, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…Phenylpropanoid glycoside acid, 4-Ob-glucopyranosyloxy-7-Zhydroxycinnamic acid and 4-Ob-glucopiranosiloxi Z-8-hydroxycinnamic acid were also isolated from the leaves. The chloroform extract gave the stem 4, 4'-dihydroxy-2'-methoxy-chalcone, (-) -Methyl gallate and syringaresinol (Table 2) (Mendes et al, 2000;Bahia et al, 2005;Borges-dos-Santos et al, 2012). The hexane phase of the root was the isolation of lupeol, acacetina, phenylpropanoid, and a mixture of sitosterol and stigmasterol.…”

Section: Introductionmentioning

confidence: 99%

Traditional use, phytochemistry and biological activities of Poincianella pyramidalys (Tul.) LP Queiroz

Chaves¹,

Silva²,

Medeiros³

et al. 2015

Afr. J. Biotechnol.

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The vegetation of Northeastern Brazil is an important source of income for the local population. Poincianella pyramidalis is a very important species in the semiarid and is inserted in various categories of ethnobotanical use, as foraging, construction and technology uses. However, the most important use is medicinal. Several preparations obtained from the root, bark, leaves and flowers of P. pyramidalis are used to treat various ailments, especially infections, pain and inflammation. This paper discusses the medical use, chemical constituents and pharmacological potential of P. pyramidalis. This revision was based on studies published in scientific journals, books, and search sites such as Science Direct, PubMed and American Chemical Society (ACS). P. pyramidalis features a wealth of secondary metabolites, belonging to the most diverse classes as flavonoids, terpenoids, tannins and others. Of these, 22 compounds were included in this review. The species showed significant ability to perform biological activities such as antimicrobial, anti-inflammatory, gastroprotective, radioprotective and anticancer, as well as being both a molluscicide and larvicide. On the other hand, the species showed relative toxicity. Numerous compounds in P. pyramidalis were identified with recognized action on the body, where anti-inflammatory and antimicrobial activities were the most pronounced. All parts of the plant stem, flower, root and leaf showed pharmacological action validating many traditional uses. However, the identification of the chemical constituents or group responsible for producing these therapeutic actions, as well as carrying out of further test in vivo to determine the mechanisms of action related to biological activities is required.

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“…In folk medicine, its flowers, seeds, leaves and bark of the stem are used for the treatment of catarrhal infections, diarrheas and dysentery, besides being endowed with antipyretic and diuretic properties (Mendes et al, 2000;Braga, 1960;Rêgo Júnior et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…A large number of metabolites have been isolated from `catingueira`, such as: phenylpropanoids, lupeol, β-sitosterol, bioflavonoids (agastiflavone, amentoflavone, sequoiaflavone and podocarpusflavone), chalcone, kaempferol, apigenin, lignane, stigamasterol and methyl gallate (Mendes et al, 2000;Bahia et al, 2010;Novais et al, 2003). Crude ethyl acetate from the leaves and roots of C. pyramidalis Tull.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity and bioautographic study of antistaphylococcal components from Caesalpinia pyramidalis Tull.

Saraiva

Gonçalves

et al. 2012

Braz. J. Pharm. Sci.

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The antimicrobial activity of dry methanol and ethyl acetate extracts for the leaves, bark of the stem, peel of the root, flower, fruit and seed of Caesalpinia pyramidalis Tull. (catingueira) was performed against seventeen isolates of Staphylococcus aureus MRSA multiresistant strains, which included two isolates of S. aureus MSSA and two ATCC strains. The antimicrobial activity was tested by the agar diffusion method and the Minimum Inhibitory Concentration (MIC) was determined. The dry methanol extract of the root showed good antimicrobial activity with a MIC of less than 0.5 mg.mL . The dry ethyl acetate extracts exhibited lower antimicrobial activity, which might be explained by solubility problems and less diffusion in the agar medium. Results of the bioautographies also confirmed inhibition halos corresponding to the active substances present in the leaves, as well as in the flower of C. pyramidalis. The phytochemical study of the leaves, bark of the stem, peel of the root, flower and fruit of extracts from C. pyramidalis confirmed the presence of a number of known antimicrobial agents including ursolic acid, quercetin, catechin, ellagic acid, sitosterol, flavonoids, proanthocyanidins and gallic acid. A determinação da atividade antimicrobiana dos extratos metanólicos e em acetato de etila da folha, casca do caule, casca da raiz, flor, fruto e semente de Caesalpinia pyramidalis Tull. foi realizada frente a dezessete isolados de Staphylococcus aureus MRSA multirresistentes, dois isolados de S. aureus MSSA e duas cepas padrão, pelas técnicas de poço/difusão em ágar e determinação das CMI pelo método de diluição em agar/multiinoculador de Stears. O extrato metanólico de casca da raiz indicou uma boa atividade, com CMI inferior a 0.5 mg.mL -1 . Os extratos secos por extração em acetato de etila apresentaram menor atividade que se poderia explicar por problemas de solubilidade e menor difusão no meio de cultura em ágar. Resultados das bioautografias confirmaram zonas de inibição correspondente às substâncias ativas presente na folha, como também na flor da C. pyramidalis. No estudo fitoquímico das folhas, casca da caule, casca da raiz, flor e fruto dos extratos de C. pyramidalis evidenciou-se a presença de vários constituintes com reconhecida atividade antimicrobiana, entre estes o ácido ursólico, quercetina, catequina, ácido elágico, sitosterol, flavonóides, proantocianidinas e ácido gálico. Entre todos os metabólitos citados, somente o ultimo não observamos, por CCD, na casca da raiz de C. pyramidalis. Unitermos

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Constituents of Caesalpinia pyramidalis

Abstract: Two new glycosyl phenylpropenoid acids, 4-O-beta-glucopyranosyloxy-(Z)-7-hydroxycinnamic acid (1) and 4-O-beta-glucopyranosyloxy-(Z)-8-hydroxycinnamic acid (2), besides lupeol and aghatisflavone, were isolated from the leaves of Caesalpinia pyramidalis.

Cited by 35 publications

References 3 publications

Thermal Degradation Kinetics of Kaempferol and Quercetin in the Pre-Formulated of the Standardized Extracts of Poincianella Pyramidalis (Tul.) L. P. Queiroz Obtained by Spray Dryer

Thermal Degradation Kinetics of Kaempferol and Quercetin in the Pre-Formulated of the Standardized Extracts of Poincianella Pyramidalis (Tul.) L. P. Queiroz Obtained by Spray Dryer

Traditional use, phytochemistry and biological activities of Poincianella pyramidalys (Tul.) LP Queiroz

Antimicrobial activity and bioautographic study of antistaphylococcal components from Caesalpinia pyramidalis Tull.

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