Consolidated bioprocessing of cellulosic biomass: an update

Lynd, Lee R.; Zyl, Willem H. van; McBride, John E.; Laser, Mark

doi:10.1016/j.copbio.2005.08.009

Cited by 1,237 publications

(829 citation statements)

References 48 publications

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“…Cellulase is also frequently used in animal feeds to improve digestion, nutrient absorption and weight gain [45], especially for herbivorous fish, unable to produce cellulase endogenously to digest plant materials [46]. Additionally, previous studies suggested that cellulase could increase the amylase and protease activities and then promote the growth of fish [47], which is extremely important for stomachless fish.…”

Section: Discussionmentioning

confidence: 99%

Identification and characterization of Bacillus subtilis from grass carp (Ctenopharynodon idellus) for use as probiotic additives in aquatic feed

Guo

Chen

Kong

et al. 2016

Fish & Shellfish Immunology

103

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Section: Discussionmentioning

confidence: 99%

Identification and characterization of Bacillus subtilis from grass carp (Ctenopharynodon idellus) for use as probiotic additives in aquatic feed

Guo

Chen

Kong

et al. 2016

Fish & Shellfish Immunology

103

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“…Once the crucial issues related to substrate range and inhibitor tolerance have been successfully addressed, a next key target for yeast-based ethanol research is likely to be the 'consolidated bioprocessing' approach (Lynd et al 2005), i.e. the functional expression of cellulolytic enzymes and other hydrolases in ethanol-producing microbial strains.…”

Section: Discussionmentioning

confidence: 99%

Alcoholic fermentation of carbon sources in biomass hydrolysates by Saccharomyces cerevisiae: current status

Maris

Abbott

Bellissimi

et al. 2006

Antonie van Leeuwenhoek

427

272

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Fuel ethanol production from plant biomass hydrolysates by Saccharomyces cerevisiae is of great economic and environmental significance. This paper reviews the current status with respect to alcoholic fermentation of the main plant biomass-derived monosaccharides by this yeast. Wild-type S. cerevisiae strains readily ferment glucose, mannose and fructose via the Embden-Meyerhof pathway of glycolysis, while galactose is fermented via the Leloir pathway. Construction of yeast strains that efficiently convert other potentially fermentable substrates in plant biomass hydrolysates into ethanol is a major challenge in metabolic engineering. The most abundant of these compounds is xylose. Recent metabolic and evolutionary engineering studies on S. cerevisiae strains that express a fungal xylose isomerase have enabled the rapid and efficient anaerobic fermentation of this pentose.L-Arabinose fermentation, based on the expression of a prokaryotic pathway in S. cerevisiae, has also been established, but needs further optimization before it can be considered for industrial implementation. In addition to these already investigated strategies, possible approaches for metabolic engineering of galacturonic acid and rhamnose fermentation by S. cerevisiae are discussed. An emerging and major challenge is to achieve the rapid transition from proof-of-principle experiments under 'academic' conditions (synthetic media, single substrates or simple substrate mixtures, absence of toxic inhibitors) towards efficient conversion of complex industrial substrate mixtures that contain synergistically acting inhibitors.

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“…The successful use of E. coli or S. cerevisiae to produce alternative biofuels will require a better understanding of their physiology under a variety of conditions and subsequent strain improvements [ 10]. Continuous advances in 'omics' technologies, computational systems biology, and synthetic biology make it possible to better understand and engineer fuel production hosts with desired phenotypes [6,14]. Route from sunlight to fuels.…”

Section: Production Hostmentioning

confidence: 99%

“…In particular, production hosts must natively have or be endowed with several important characteristics: extension of the substrate range, elimination of cellulose hydrolysates and biofuel product toxicity, and improvement of global regulatory functions. One method that has been proposed to reduce fuel production cost is to perform cellulose hydrolysis and fermentation in one step, called consolidated bioprocessing (CBP); this alternative approach avoids costs associated with cellulase production [ 14].…”

Section: Production Hostmentioning

confidence: 99%

Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels

Lee

Chou

Ham

et al. 2008

Current Opinion in Biotechnology

540

298

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The ability to generate microorganisms that can produce biofuels similar to petroleum-based transportation fuels would allow the use of existing engines and infrastructure and would save an enormous amount of capital required for replacing the current infrastructure to accommodate biofuels that have properties significantly different from petroleum-based fuels. Several groups have demonstrated the feasibility of manipulating microbes to produce molecules similar to petroleum-derived products, albeit at relatively low productivity (e.g. maximum butanol production is around 20 g/L). For cost-effective production of biofuels, the fuel-producing hosts and pathways must be engineered and optimized. Advances in metabolic engineering and synthetic biology will provide new tools for metabolic engineers to better understand how to rewire the cell in order to create the desired phenotypes for the production of economically viable biofuels.

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Consolidated bioprocessing of cellulosic biomass: an update

Cited by 1,237 publications

References 48 publications

Identification and characterization of Bacillus subtilis from grass carp (Ctenopharynodon idellus) for use as probiotic additives in aquatic feed

Identification and characterization of Bacillus subtilis from grass carp (Ctenopharynodon idellus) for use as probiotic additives in aquatic feed

Alcoholic fermentation of carbon sources in biomass hydrolysates by Saccharomyces cerevisiae: current status

Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels

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