Consolidated and Labile Odor Memory Are Separately Encoded within the<i>Drosophila</i>Brain

Scheunemann, Lisa; Jost, Eva; Richlitzki, Antje; Day, Jonathan P.; Sebastian, Sujith; Thum, Andreas S.; Efetova, Marina; Davies, Shireen-A.; Schwärzel, Martin

doi:10.1523/jneurosci.3286-12.2012

Cited by 45 publications

(36 citation statements)

References 71 publications

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“…ASM and ARM rely on different molecular and neuronal mechanisms (Folkers et al, 1993; Tully et al, 1994; Scheunemann et al, 2012). Amnestic cooling abolishes the labile ASM and is, thus, used to separate both components.…”

Section: Resultsmentioning

confidence: 99%

Drep-2 is a novel synaptic protein important for learning and memory

Andlauer

Scholz-Kornehl

Tian

et al. 2014

eLife

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CIDE-N domains mediate interactions between the DNase Dff40/CAD and its inhibitor Dff45/ICAD. In this study, we report that the CIDE-N protein Drep-2 is a novel synaptic protein important for learning and behavioral adaptation. Drep-2 was found at synapses throughout the Drosophila brain and was strongly enriched at mushroom body input synapses. It was required within Kenyon cells for normal olfactory short- and intermediate-term memory. Drep-2 colocalized with metabotropic glutamate receptors (mGluRs). Chronic pharmacological stimulation of mGluRs compensated for drep-2 learning deficits, and drep-2 and mGluR learning phenotypes behaved non-additively, suggesting that Drep 2 might be involved in effective mGluR signaling. In fact, Drosophila fragile X protein mutants, shown to benefit from attenuation of mGluR signaling, profited from the elimination of drep-2. Thus, Drep-2 is a novel regulatory synaptic factor, probably intersecting with metabotropic signaling and translational regulation.DOI: http://dx.doi.org/10.7554/eLife.03895.001

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Section: Resultsmentioning

confidence: 99%

Drep-2 is a novel synaptic protein important for learning and memory

Andlauer

Scholz-Kornehl

Tian

et al. 2014

eLife

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“…The Gal4 driver SG18.1 activates strong expression in the clusters of olfactory INs, PNs, and a class of EB neurons (Fig. A,B), identified as per Scheunemann et al () and Zhang et al (). Figure B shows PNs which are larger in size and extend axons into AL, EB neurons which are located anterolateral to MB lobes with axonal projection toward EB ring neuropile, INs (Fig.…”

Section: Resultsmentioning

confidence: 65%

Developmental Deformity Due to scalloped Non‐Function in Drosophila Brain Leads to Cognitive Impairment

Rohith

Shyamala

2019

Developmental Neurobiology

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Neural identity and wiring specificity are fundamental to brain function. Factors affecting proliferation of the progenitor cells leading to an expansion or regression of specific neuronal clusters are expected to challenge the process of formation of precise synaptic connections with their partners and their further integration to result in proper functional neural circuitry. We have investigated the role of scalloped, a Hippo pathway gene in Drosophila brain development and have shown that its function is critical to regulate proliferation of Mushroom Body Neuroblasts and to limit the neuronal cluster size to normal in the fly brain. Here we investigate the consequent effect of the anatomical phenotype of mutant flies on the brain function, as exemplified by their cognitive performance. We demonstrate that the neural expansion in important neural clusters of the olfactory pathway, caused due to Scalloped inactivation, imparts severe disabilities in learning, short-term memory and long-term memory. Scalloped knockdown in αβ Kenyon Cell clusters drastically reduces long-term memory performance. Scalloped deficiency induced neural expansion in antennal lobe and ellipsoid body neurons bring down short-term memory performance significantly. We also demonstrate that the cognitive impairments observed here are not due to a problem in memory formation or execution in the adult, but are due to the developmental deformities caused in the respective class of neurons. Our results strongly indicate that the additional neurons generated by Scalloped inactivation are not synergistically integrated into, but rather perturb the formation of precise functional circuitry.

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“…ITM is composed of two memory components, consolidated anesthesia-resistant memory (ARM) and labile anesthesia-sensitive memory (ASM) (Quinn and Dudai, 1976;Tully et al, 1994). ASM and ARM rely on different molecular and neuronal mechanisms (Folkers et al, 1993;Tully et al, 1994;Scheunemann et al, 2012). Amnestic cooling abolishes the labile ASM and is, thus, used to separate both components.…”

Section: Drep-2 Is Required In Kcs For Normal Olfactory Short-and Intmentioning

confidence: 99%

Author response: Drep-2 is a novel synaptic protein important for learning and memory

Andlauer

Scholz-Kornehl

Tian

et al. 2014

View full text Add to dashboard Cite

CIDE-N domains mediate interactions between the DNase Dff40/CAD and its inhibitor Dff45/ICAD. In this study, we report that the CIDE-N protein Drep-2 is a novel synaptic protein important for learning and behavioral adaptation. Drep-2 was found at synapses throughout the Drosophila brain and was strongly enriched at mushroom body input synapses. It was required within Kenyon cells for normal olfactory short-and intermediate-term memory. Drep-2 colocalized with metabotropic glutamate receptors (mGluRs). Chronic pharmacological stimulation of mGluRs compensated for drep-2 learning deficits, and drep-2 and mGluR learning phenotypes behaved non-additively, suggesting that Drep 2 might be involved in effective mGluR signaling. In fact, Drosophila fragile X protein mutants, shown to benefit from attenuation of mGluR signaling, profited from the elimination of drep-2. Thus, Drep-2 is a novel regulatory synaptic factor, probably intersecting with metabotropic signaling and translational regulation.

show abstract

Consolidated and Labile Odor Memory Are Separately Encoded within theDrosophilaBrain

Cited by 45 publications

References 71 publications

Drep-2 is a novel synaptic protein important for learning and memory

Drep-2 is a novel synaptic protein important for learning and memory

Developmental Deformity Due to scalloped Non‐Function in Drosophila Brain Leads to Cognitive Impairment

Author response: Drep-2 is a novel synaptic protein important for learning and memory

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