Considerations for exerkine research focusing on the response to exercise training

Darragh, Ian A.J.; Egan, Brendan

doi:10.1016/j.jshs.2023.11.002

Cited by 2 publications

(2 citation statements)

References 19 publications

(35 reference statements)

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“…One of the mechanisms by which exercise mediates its beneficial effects consists of a systemic crosstalk mediated EVs containing different molecules, including miRNAs 27 28 29 . However, it remains unresolved the secretory role of skeletal muscle in the response to training and which miRNAs encapsulated in EVs could be relevant in this context, acting as exerkines 30 . Traditionally, the characterization of miRNAs contained in EVs in response to acute exercise and training has focused on skeletal muscle-associated miRNAs (myomiRs), such as miR-1, miR-206 and miR-133b (reviewed in 7 ).…”

Section: Discussionmentioning

confidence: 99%

miR-29a-3p, a new myokine orchestrating resistance exercise via coordinated metabolic responses

Pinto-Hernandez,

Fernandez-Sanjurjo,

Paget

et al. 2024

Preprint

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It remains unclear whether the adaptive response to different exercise models is mediated by EV miRNAs released from skeletal muscle and their functional metabolic role. We sequenced miRNA-loaded plasma EVs obtained from resting mice after 4-weeks endurance or resistance training. Resistance exercise increased the expression of a 11-miRNA profile grouped into two functional clusters. Using both genetically modified animal models and in vitro approaches, we have identified miR-29a-3p as a novel myokine secreted into the bloodstream as EV cargo by contracting skeletal muscle. It is a cornerstone in the adaptation to resistance training by mediating the coordinated expression and secretion of other miRNAs and affecting muscle mass development and energy metabolism in muscle and liver. Taken together, our study suggests a coordinating and determinant role of miR-29a-3p in the response and adaptation to resistance training, possibly due to its role as a myokine through its regulatory role in energy metabolism.

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Section: Discussionmentioning

confidence: 99%

miR-29a-3p, a new myokine orchestrating resistance exercise via coordinated metabolic responses

Pinto-Hernandez,

Fernandez-Sanjurjo,

Paget

et al. 2024

Preprint

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“…The effect of these exerkines on adaption processes might differ between acute and chronic exercise settings. 26 …”

Section: Exerkines: Exercise-inducible Signaling Moleculesmentioning

confidence: 99%

Molecular insights of exercise therapy in disease prevention and treatment

Walzik,

Wences Chirino,

Zimmer

et al. 2024

Sig Transduct Target Ther

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Despite substantial evidence emphasizing the pleiotropic benefits of exercise for the prevention and treatment of various diseases, the underlying biological mechanisms have not been fully elucidated. Several exercise benefits have been attributed to signaling molecules that are released in response to exercise by different tissues such as skeletal muscle, cardiac muscle, adipose, and liver tissue. These signaling molecules, which are collectively termed exerkines, form a heterogenous group of bioactive substances, mediating inter-organ crosstalk as well as structural and functional tissue adaption. Numerous scientific endeavors have focused on identifying and characterizing new biological mediators with such properties. Additionally, some investigations have focused on the molecular targets of exerkines and the cellular signaling cascades that trigger adaption processes. A detailed understanding of the tissue-specific downstream effects of exerkines is crucial to harness the health-related benefits mediated by exercise and improve targeted exercise programs in health and disease. Herein, we review the current in vivo evidence on exerkine-induced signal transduction across multiple target tissues and highlight the preventive and therapeutic value of exerkine signaling in various diseases. By emphasizing different aspects of exerkine research, we provide a comprehensive overview of (i) the molecular underpinnings of exerkine secretion, (ii) the receptor-dependent and receptor-independent signaling cascades mediating tissue adaption, and (iii) the clinical implications of these mechanisms in disease prevention and treatment.

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Considerations for exerkine research focusing on the response to exercise training

Cited by 2 publications

References 19 publications

miR-29a-3p, a new myokine orchestrating resistance exercise via coordinated metabolic responses

miR-29a-3p, a new myokine orchestrating resistance exercise via coordinated metabolic responses

Molecular insights of exercise therapy in disease prevention and treatment

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