miR-29a-3p, a new myokine orchestrating resistance exercise via coordinated metabolic responses
Paola Pinto-Hernandez,
Manuel Fernandez-Sanjurjo,
Daan Paget
et al.
Abstract:It remains unclear whether the adaptive response to different exercise models is mediated by EV miRNAs released from skeletal muscle and their functional metabolic role. We sequenced miRNA-loaded plasma EVs obtained from resting mice after 4-weeks endurance or resistance training. Resistance exercise increased the expression of a 11-miRNA profile grouped into two functional clusters. Using both genetically modified animal models and in vitro approaches, we have identified miR-29a-3p as a novel myokine secreted… Show more
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