Conservative treatment followed by chemotherapy with doxorubicin and ifosfamide for cervical sarcoma botryoides in young females

Zanetta, Gerardo; Rota, S.; Lissoni, Andrea Alberto; Chiari, Stefania; Bratina, G; Mangioni, Costantino

doi:10.1038/sj.bjc.6690370

Cited by 26 publications

(19 citation statements)

References 13 publications

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Section: Discussionmentioning

confidence: 99%

“…Previous investigations of ovarian preservation for women with stage I epithelial ovarian cancer consisted primarily of small retrospective reports 15‐19. In those studies, the recurrence rate after fertility‐sparing surgery ranged from 4% to 28% 15‐17. Most studies included stage IA and IC tumors, although fertility‐sparing surgery was reported in a small number of women with more advanced stage disease 15‐18.…”

Section: Discussionmentioning

confidence: 99%

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Fertility preservation in young women with epithelial ovarian cancer

Wright

Shah

Mathew

et al. 2009

Cancer

134

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BACKGROUND: Surgical management of ovarian cancer consists of hysterectomy with bilateral oophorectomy. In young women, this results in the loss of reproductive function and estrogen deprivation. In the current study, the authors examined the safety of fertility‐conserving surgery in premenopausal women with epithelial ovarian cancers. METHODS: Women aged ≤50 years with stage IA or IC epithelial ovarian cancer who were registered in the Surveillance, Epidemiology, and End Results database were examined. Patients who underwent bilateral oophorectomy were compared with those who underwent ovarian conservation. A second analysis examined uterine conservation versus hysterectomy. Multivariate Poisson regression models were developed to describe predictors of fertility preservation. Survival was examined using Cox proportional hazards models and the Kaplan‐Meier method. RESULTS: In total, 1186 women, including 754 women (64%) who underwent bilateral oophorectomy and 432 women (36%) who underwent ovarian preservation, were identified. Younger age, later year of diagnosis, and residence in the eastern or western United States were associated with ovarian preservation (P < .05 for all). Women with endometrioid and clear cell histologies and stage IC disease were less likely to have ovarian conservation (P < .05). In a Cox model, ovarian preservation had no effect on survival (hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.39‐1.20). Young age, later year of diagnosis, residence in the eastern or western United States, single women, mucinous tumors, and patients with stage IA disease were more likely to have uterine preservation (P < .05 for all). In a multivariate model, uterine preservation had no effect on survival (HR, 0.87; 95% CI, 0.62‐1.22). CONCLUSIONS: Ovarian and uterine‐conserving surgery were safe in young women who had stage IA and IC epithelial ovarian cancer. Cancer 2009. © 2009 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fertility preservation in young women with epithelial ovarian cancer

Wright

Shah

Mathew

et al. 2009

Cancer

134

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“…However, while ultra-minimally-invasive procedures such as simple polypectomy for an exophytic, botryoid sarcoma have been reported, they carry the hazard of leaving behind residual gross or microscopic disease. Of three patients reported by Zanetta and colleagues who underwent simple polypectomy for cervical sarcoma botryoides, one suffered a local recurrence and a second was found to have an additional focus of disease in the endocervical canal [8]. Most recurrences of rhabdomyosarcoma of the female genital tract are locoregional [3].…”

Section: Discussionmentioning

confidence: 99%

Pediatric radical abdominal trachelectomy for anaplastic embryonal rhabdomyosarcoma of the uterine cervix: an alternative to radical hysterectomy

Kayton

Wexler

Lewin

et al. 2009

Journal of Pediatric Surgery

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Rhabdomyosarcoma arising in the female genital tract carries five-year survival in excess of 80%, but lifelong infertility may be a consequence of local control strategies. We present the technique and outcome for a fertility-sparing, radical abdominal trachelectomy in a 12-year-old girl with anaplastic, embryonal rhabdomyosarcoma involving the uterine cervix. The patient had presented to our center following the piecemeal resection of a uterine cervical mass; because of concern about microscopic residual disease, we classified her as group II-A according to the International Rhabdomyosarcoma Study (IRS) system. Staging studies excluded the presence of distant disease. The patient received four cycles of multiagent chemotherapy and then underwent radical abdominal trachelectomy, with removal of the uterine cervix, parametria, vaginal cuff, and regional lymph nodes. Microscopically, the specimen showed treatment effect and no residual tumor. Regional nodes were negative. Radical abdominal trachelectomy, which has not been previously reported for rhabdomyosarcoma, has appeared to secure local disease control in this case, while preserving the patient’s future fertility potential. In properly selected cases of rhabdomyosarcoma of the uterine cervix, where involvement of the uterus proper is not present, radical abdominal trachelectomy may be an attractive fertility-sparing alternative to radical hysterectomy.

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“…8 Several other lesions enter into the pathologic differential diagnosis, including adenosarcoma, edematous cervical mesodermal polyps (pseudosarcoma botryoides), rhabdomyoma, and other tumors. 9 Adenosarcomas can also be found in young women but histologically can be distinguished from sarcoma botryoides by their fibrous stroma and leaf-like pattern of glands. The major surgical treatment for rhabdomyosarcoma which was performed in our patient consisted of complete resection of the primary tumor with a surrounding "margin" of normal tissue.…”

Section: Discussionmentioning

confidence: 99%

“…The prognosis becomes better especially when the tumor arises in a single polypoid lesion and is completely removed during surgery. 9 There are some prognostic factors defined for this tumor. Te majority of RMS cases occur sporadically and no predisposing factor is recognized for them.…”

Section: Discussionmentioning

confidence: 99%

Sarcoma botryoides (embryonal rhabdomyosarcoma) of the uterine cervix in sisters

Mousavi

Akhavan

2010

J Gynecol Oncol

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Sarcoma botryoides (embryonal rhabdomyosarcoma) rarely arises in the uterine cervix. We report a case of a 14-yearold female with sarcoma botryoides who presented with prolonged vaginal bleeding and cervical polyp. The biopsy specimen confirmed sarcoma botryoides. The patient underwent radical surgery of the tumor and hysterectomy without adjuvant chemotherapy. The sister of the patient had died previously due to the same diagnosis at the age of 17. We achieved a satisfactory outcome in short-term period with radical surgery and hysterectomy. Presence of sarcoma botryoides of the cervix in two sisters in the family highlights the possible role of genetic factors in the development of sarcoma botryoides.

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Conservative treatment followed by chemotherapy with doxorubicin and ifosfamide for cervical sarcoma botryoides in young females

Cited by 26 publications

References 13 publications

Fertility preservation in young women with epithelial ovarian cancer

Fertility preservation in young women with epithelial ovarian cancer

Pediatric radical abdominal trachelectomy for anaplastic embryonal rhabdomyosarcoma of the uterine cervix: an alternative to radical hysterectomy

Sarcoma botryoides (embryonal rhabdomyosarcoma) of the uterine cervix in sisters

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