Conservative treatment by irradiation of epidermoid cancers of the anal canal: Prognostic factors of tumoral control and complications

Peiffert, D.; Bey, P.; Pernot, M.; Guillemin, François; Luporsi, É.; Hoffstetter, S.; Aletti, P.; Boissel, P; Bigard, Marc‐André; Dartois, D.; Baylac, F

doi:10.1016/s0360-3016(96)00493-2

Cited by 119 publications

(50 citation statements)

References 24 publications

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“…According to the literature, the most important prognostic factors in anal cancer are T-stage [1,18,[21][22][23] and N-stage [8][9][10]18]. In our study, similar results were obtained.…”

Section: Discussionsupporting

confidence: 88%

Anal cancer chemoirradiation with curative intent – a single institution experience

Oblak¹,

Petric²,

Anderluh³

et al. 2009

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Results of radiochemotherapy in 50 patients with squamous cell carcinoma of the anal canal, treated with radical radiochemotherapy between January 2003 and September 2007, at the Institute of Oncology Ljubljana are presented. The treatment schedule consisted of 3-D conformal external beam radiotherapy (45 Gy in 25 fractions), with two cycles of concurrent chemotherapy (5-fluorouracil (5-FU) / Mitomycin C), followed by brachytherapy or external beam boost (15-30 Gy) to the primary tumor. Locoregional control (LRC), disease-free survival (DFS), disease-specific survival (DSS), overall survival (OS) and colostomy-free survival (CFS) rates and the rate of acute and chronic side-effects were estimated. The impact of individual tumor-and therapy-related factors on treatment outcome was assessed.Treatment was completed according to the protocol in 72% of patients. The median follow-up time of 40 survivors was 22 months (range 1.7-53.2 months). At 2 years, LRC, DFS, DSS, OS and CFS rates were 68%, 67%, 87%, 76% and 85%, respectively. In the multivariate analysis, nodal stage was identified as an independent prognostic factor for LRC, DSS and CFS and application of Mitomycin C for OS. The most frequent acute side-effect of treatment was radiodermatitis (grade 3 in 66% of patients, grade 4 in 2%). Late anal stenosis, chronic ulceration and grade 2-3 incontinence developed in 3 (6 %), 2 (4 %) and 5 (10 %) of colostomy-free survivors, respectively.Radiotherapy with concurrent 5-FU / Mitomycin C chemotherapy is feasible, with acceptable toxicity. The presented treatment outcome is comparable to other published results.

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“…According to the literature, the most important prognostic factors in anal cancer are T-stage [1,18,[21][22][23] and N-stage [8][9][10]18]. In our study, similar results were obtained.…”

Section: Discussionsupporting

confidence: 88%

Anal cancer chemoirradiation with curative intent – a single institution experience

Oblak¹,

Petric²,

Anderluh³

et al. 2009

neo

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“…Up to now there are only few data in anal cancer addressing the importance of the time factor on treatment outcome. Regarding the length of treatment interruption before application of the boost either by brachytherapy or external beam radiation, Peiffert et al observed a decreased local control if the gap exceeded 63 days [15] and Weber et al [16] and Deniaud-Alexandre et al [7] showed an association with improved outcome in patients treated with a gap shorter than 38 days. When considering the overall treatment time Ceresoli et al found an inferior disease-free survival in patients with an overall treatment time exceeding 70 days [17].…”

Section: Discussionmentioning

confidence: 99%

Chemoradiotherapy in patients with anal cancer: Impact of length of unplanned treatment interruption on outcome

Meyer

Eissen²,

Karstens

et al. 2006

Acta Oncologica

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“…The most important prognostic factors have been defined by several studies: a tumor originating from the anal canal is more aggressive than one originating from peri-anal skin; the size of the tumor is also important, with higher T stage correlating with worse prognosis [2,[19][20][21]; differentiation and histologic type also play roles-epidermoid carcinoma has a better prognosis than adenocarcinoma; finally, prognosis is better in females than in males [2,4].…”

Section: Prognostic Factors Tumor Location and Sizementioning

confidence: 99%

Carcinoma of the Anus: Strategies in Management

2002

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The management of anal cancer underwent an interesting transformation over the last two decades. Prior to this period, the standard definitive treatment for carcinoma of the anal canal was abdominal-perineal resection, which necessitated a permanent colostomy. The organ preservation concept appeared following the discovery of a high complete response rate from preoperative combined chemoradiation prior to abdominal-perineal resection.The organ preservation method of treatment rapidly gained popularity and ultimately saved a large number of patients from undergoing abdominal-perineal resection and colostomy. Chemoradiation treatment itself subsequently went through an evolutionary process. Several studies have sought to define the optimal chemotherapeutic regimen as well as radiation treatment dose and fractionation. Ongoing studies attempt to define an optimal treatment regimen that yields a higher cure rate while minimizing toxicity. We review the etiology, epidemiology, and treatment regimens for anal cancer.

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Conservative treatment by irradiation of epidermoid cancers of the anal canal: Prognostic factors of tumoral control and complications

Cited by 119 publications

References 24 publications

Anal cancer chemoirradiation with curative intent – a single institution experience

Anal cancer chemoirradiation with curative intent – a single institution experience

Chemoradiotherapy in patients with anal cancer: Impact of length of unplanned treatment interruption on outcome

Carcinoma of the Anus: Strategies in Management

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