Conservative Management of Segmental Multicystic Dysplastic Kidney in Children

Han, Jang Hee; Lee, Yong S.eung; Kim, Myung Joon; Lee, Mi Jung; Im, Young Jae; Kim, Sang W.oon; Han, Sang Won

doi:10.1016/j.urology.2015.07.031

Cited by 9 publications

(15 citation statements)

References 25 publications

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“…RD is generally diagnosed in early childhood, however it can be detected by foetal ultrasonography as early as 15 weeks of gestation. [1,9] In a study conducted by Singh et al only one case (4.5%) was detected at 21 years and the remaining cases (95.5%) were diagnosed from new born period to eight years. [1] In another study all the cases were diagnosed during childhood.…”

Section: Discussionmentioning

confidence: 99%

“…Potter postulated that RD is due to a primary defect in ampullary function resulting in diminished branching of ampullary portion of collecting ducts and failure of renal mesenchymal induction . [9] Other theories proposed include foetal urinary obstruction including ureteral atresia, faulty blood supply and nephrogenesis inhibition by unknown substance. [5,15] Knowing that WT1, PAX2/8 and BCL2 genes play an important role in nephrogenesis especially branching morphogenesis and nephron differentiation , it has been proposed that altered expression of these genes results in RD.…”

Section: Discussionmentioning

confidence: 99%

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Renal Dysplasia: A 6 Year Retrospective Study with Clinicopathological Correlation

Devadass

Basavaraj

Badila

et al. 2018

APALM

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The clinical details including presentation, age, sex and radiological findings and gross morphological findings were obtained from the patient's case files. The haematoxylin and eosin stained tissue sections were retrieved from the archives and were examined for the various epithelial (primitive glomeruli, primitive ducts and tubular cysts) and mesenchymal (primitive mesenchymal/fibromuscular collarets, metaplastic cartilage, thick walled blood vessels and abundant nerve bundles) microscopic morphological features. On macroscopic morphology RD was classified as: cystic/ multicystic, hypodysplastic, segmental and obstructive.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Renal Dysplasia: A 6 Year Retrospective Study with Clinicopathological Correlation

Devadass

Basavaraj

Badila

et al. 2018

APALM

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“…The contralateral kidney should be examined thoroughly for dysplasia and other congenital uropathies, as this affects overall renal prognosis (25). Atypical presentation can occur with MCDK in only one moiety of a duplex or horseshoe kidney or in an ectopic kidney (26).…”

Section: Multicystic Dysplastic Kidneymentioning

confidence: 99%

Imaging of Kidney Cysts and Cystic Kidney Diseases in Children: An International Working Group Consensus Statement

Gimpel¹,

Avni²,

Breysem³

et al. 2019

Radiology

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ystic kidney diseases are being diagnosed earlier and earlier (1) because of more accessible routine prenatal US and advances in US technology. However, differential diagnosis often remains a challenge because kidney cysts can arise in a large variety of illnesses, imaging patterns evolve over time, and extrarenal features of systemic diseases may not be present at a young age. Thus, imaging findings for a particular disease in newborns may be different from those in adolescents, and predicting prognosis or deciding on optimal follow-up intervals can be challenging. Imaging can contribute not only to accurate diagnosis and prognosis but also to rational management of cystic nephropathies. In adults with autosomal dominant polycystic kidney disease (ADPKD), for example, total kidney volume measured at MRI has emerged as a useful tool with which to identify patients who will benefit from treatment (2); however, transfer and adaptation of these findings to children is still an important research need. The purpose of this consensus statement is to establish uniform standards for choosing the correct imaging modality and diagnostic criteria for the most common cystic kidney diseases in childhood and adolescence and to propose rational approaches to diagnosis and follow-up in important clinical settings. The spectrum of diseases covered here includes simple cysts; multicystic dysplastic kidneys (MCDKs); cystic dysplasia and HNF1B-associated disease; autosomal recessive polycystic kidney disease (ARPKD) and ADPKD; other ciliopathies, such as nephronophthisis and Bardet-Biedl syndrome; acquired cystic kidney disease

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“…Additionally, it was deemed that there was no need to remove the affected kidney (8,9). Most of the scholars and parents that supported conservative treatment concentrated on the potential risks, the costs and injuries of the surgery itself (10,11). However, other investigators support surgical resection of the affected kidney.…”

Section: Introductionmentioning

confidence: 99%

Minimally invasive open nephrectomy on children with multicystic dysplastic kidney

Feng

Zhu

Sun

et al. 2016

Experimental and Therapeutic Medicine

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The aim of the study was to summarize the preliminary experience of minimally invasive open nephrectomy operation on children with multicystic dysplastic kidney (MCDK). A retrospective review was performed on the clinical materials of the 15 children that had accepted consecutive minimally invasive open nephrectomies during the previous 2 years. The enrolled children were diagnosed with unilateral MCDK under computed tomography, emission computerized tomography and ultrasound and no anomaly in the contralateral functioning kidney was found. Of the 15 children, 12 were boys and 3 were girls, with 5 cases on the right and 10 cases on the left. Operations were completed at the retroperitoneal space in order to open an incision on the waists and ribs of the children, the length of which ranged from 1.5 to 2.0 cm (average 1.7 cm). The age of the children at operation ranged from 3 months to 5.6 years old, with an average of 2.4 years old. Surgery lasted for 30–50 min, with an average of 34.6 min. The estimated blood loss of each child was <5 ml. After operation, prophylactic intravenous antibiotics were administered for 2–4 days to prevent infection. All of the operations proved very successful. Following surgery the children were hospitalized for 2–4 days for observation, with an average of 2.8 days. No complications occurred during the follow-up period. In conclusion, minimally invasive open nephrectomy is effective for children with MCDK. The procedure is superior with regard to operative time, cosmesis, and length of stay. It is a safe and effective treatment choice for patietns with MCDK and can be easily performed on children.

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Conservative Management of Segmental Multicystic Dysplastic Kidney in Children

Cited by 9 publications

References 25 publications

Renal Dysplasia: A 6 Year Retrospective Study with Clinicopathological Correlation

Renal Dysplasia: A 6 Year Retrospective Study with Clinicopathological Correlation

Imaging of Kidney Cysts and Cystic Kidney Diseases in Children: An International Working Group Consensus Statement

Minimally invasive open nephrectomy on children with multicystic dysplastic kidney

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