“…The effectiveness of topical treatment shown in this systematic review is corroborated by many case series on treatments for CSOM (26,29,38,64,69,89,115,133,144), as well as by expert opinions in many widely accepted textbooks in otolaryngology (39,47,110,116,135,152). Powdered antibiotics and antiseptics are routinely recommended when there is good access to the middle ear cavity, such as in cases of subtotal tympanic perforations or draining mastoid cavities (85).…”