Conservation of Death Receptor-6 in Avian and Piscine Vertebrates

Bridgham, Jamie T.; Bobe, Julien; Goetz, Frederick W.; Johnson, A. L.

doi:10.1006/bbrc.2001.5093

Cited by 20 publications

(12 citation statements)

References 29 publications

(26 reference statements)

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“…studies [21,[35][36][37], but they are not found in Drosophila or Caenorhabditis elegans [22,32]. Thus, they are previously thought to be a chordate invention.…”

Section: Xep75na1 307 --Mh L H N K L S S H K Q E E -V E K L L S G S Lmentioning

confidence: 99%

First molluscan TNFR homologue in Zhikong scallop: Molecular characterization and expression analysis

Qiu

Song

et al. 2009

Fish & Shellfish Immunology

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“…studies [21,[35][36][37], but they are not found in Drosophila or Caenorhabditis elegans [22,32]. Thus, they are previously thought to be a chordate invention.…”

Section: Xep75na1 307 --Mh L H N K L S S H K Q E E -V E K L L S G S Lmentioning

confidence: 99%

First molluscan TNFR homologue in Zhikong scallop: Molecular characterization and expression analysis

Qiu

Song

et al. 2009

Fish & Shellfish Immunology

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“…There is also evidence of additional transcriptional variants that were not pursued in the present study. Combined with the previously characterized chFas (TNFRSF6) and chTNFR1 (TNFRSF1A) [13], TvB (a TNFRSF10B-like DR [39,40]), chDR6 (TNFRSF21 [41]), and ch p75 NTR (TNFRSF16 [42]; unpublished data), ch-TNFRSF23.v1 now represents the sixth DR thus far known to be expressed by tissues from the hen ovary. Moreover, along with the recently reported ch osteoprotegerin 976 BRIDGHAM AND JOHNSON FIG.…”

Section: Discussionmentioning

confidence: 68%

Alternatively Spliced Variants of Gallus gallus TNFRSF23 Are Expressed in the Ovary and Differentially Regulated by Cell Signaling Pathways1

Bridgham¹,

Johnson²

2004

Biology of Reproduction

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As a result of searching recently available chicken (ch) expressed sequence tag databases, a new Tumor Necrosis Factor Receptor Super Family (TNFRSF) member with similarity to the murine (m) TNFRSF23 decoy receptor (DcR) has been identified. However, by comparison with the mTNFRSF23, there exist at least two splice variants of chTNFRSF23, one of which includes an intracellular death domain (TNFRSF23.v1) characteristic of death receptors, and the other with a truncated cytoplasmic domain of a DcR (named TNFRSF23.v2). These two splice variants of chTNFRSF23 display differential patterns of mRNA expression across various hen tissues, with the highest levels observed within reproductive tissues. More specifically, TNFRSF23.v1 is most highly expressed in preovulatory follicle granulosa cells in the ovary, whereas TNFRSF23.v2 mRNA is found at highest levels in ovarian stromal tissue. Primary culture experiments with granulosa cells determined that expression of TNFRSF23.v1 mRNA was decreased by protein kinase A signaling and enhanced by transforming growth factor (TGF) alpha treatment. Interestingly, TGFbeta1 and signaling via protein kinase C also enhanced levels of TNFRSF23.v1 expression but only in undifferentiated granulosa cells from prehierarchal follicles. Based on patterns of mRNA expression and its endocrine/paracrine regulation, we predict that ovarian chTNFRSF23 represents a modulator of granulosa cell survival and/or differentiation. Finally, the characterization of these receptor variants is of considerable interest from an evolutionary perspective in that they provide additional evidence to support a continuing divergence of TNFRSF members throughout vertebrate evolution.

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“…Moreover, given its widespread expression patterns, it is likely important in other tissue types as well. 21,43 The second major functional category encompasses the remaining death receptors representing three separate clades, all of which play a role in mediating the immune response ( Figure 3, subgroup b). Notably, the ancient divergence of these receptors occurs coincident with the emergence of the acquired immune response in vertebrate species.…”

Section: G E L G -Y Q D E I I D S F T -R E E F P ----V R a M L S D W mentioning

confidence: 99%

“…Significantly, all five of the currently identified Gallus death receptors (tumor necrosis factor receptor-I [TNFRI], Fas, TVB, p75 neurotrophin receptor [p75NTR], and death receptor 6 [DR6]) are known to be expressed in granulosa cells (Figure 1). A functional role for such receptors during atresia is suggested by the fact that four of the five receptors (TNFRI, Fas, DR6, TVB) are expressed at higher levels in atretic follicles compared to morphologically and functionally normal follicles (DR6 21 ; Fas and TNFRI, 22 TVB, 23 p75NTR, Johnson, unpublished).…”

Section: Introductionmentioning

confidence: 99%

All in the family: evolutionary and functional relationships among death receptors

et al. 2003

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Over the last decade, significant progress has been made towards identifying the signaling pathways within mammalian cells that lead to apoptosis mediated by death receptors. The simultaneous expression of more than one death receptor in many, if not all, cell types suggests that functional innovation has driven the divergence of these receptors and their cognate ligands. To better understand the physiological divergence of the death receptors, a phylogenetic analysis of vertebrate death receptors was conducted based upon aminoacid sequences encoding the death domain regions of currently known and newly identified members of the family. Evidence is presented to indicate an ancient radiation of death receptors that predates the emergence of vertebrates, as well as ongoing divergence of additional receptors both within several receptor lineages as well as modern taxonomic lineages. We speculate that divergence among death receptors has led to their functional specialization. For instance, some receptors appear to be primarily involved in mediating the immune response, while others play critical roles during development and tissue differentiation. The following represents an evolutionary approach towards an understanding of the complex relationship among death receptors and their proposed physiological functions in vertebrate species.

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Conservation of Death Receptor-6 in Avian and Piscine Vertebrates

Cited by 20 publications

References 29 publications

First molluscan TNFR homologue in Zhikong scallop: Molecular characterization and expression analysis

First molluscan TNFR homologue in Zhikong scallop: Molecular characterization and expression analysis

Alternatively Spliced Variants of Gallus gallus TNFRSF23 Are Expressed in the Ovary and Differentially Regulated by Cell Signaling Pathways1

All in the family: evolutionary and functional relationships among death receptors

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