Consequences on aging process and human wellness of generation of nitrogen and oxygen species during strenuous exercise

Sessa, Francesco; Messina, Giovanni; Russo, Roberto; Salerno, Monica; Castracani, Carlo Castruccio; Distefano, Alfio; Volti, Giovanni Li; Calogero, Aldo E.; Cannarella, Rossella; Mongioì, Laura M.; Condorelli, Rosita A.; Vignera, Sandro La

doi:10.1080/13685538.2018.1482866

Cited by 16 publications

(15 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding seems to be in contrast with data reported elsewhere (29). However, it is necessary to take into account the great intra and interindividual variability of these parameters also in consideration of confounding factors, such as, for example, the use of supplements with antioxidant properties so widespread in our society (33). Furthermore, it should be noted that men enrolled in this study had an average age of 35.1 ± 8.2 years with an age range of 18-55 years, therefore younger than the studies that showed an increase in oxidative stress over time (29).…”

Section: Discussioncontrasting

confidence: 74%

Bio-Functional Sperm Parameters: Does Age Matter?

et al. 2020

Self Cite

View full text Add to dashboard Cite

The evaluation of biofunctional sperm parameters can explain some cases of idiopathic male infertility. Among these, sperm DNA fragmentation (fDNA) is the most studied biofunctional sperm parameter. Mitochondrial membrane potential (MMP) correlates positively with sperm motility, the evaluation of sperm apoptosis by flow cytometry allows us to identify a population of spermatozoa not recognizable at the optical microscopy and finally, lipid peroxidation (LP) and mitochondrial superoxide levels measurements are rational oxidative stress indices. Male age seems to affect sperm concentration and sperm fDNA. For these reasons, this study was undertaken to evaluate the correlation, if any, between male age and biofunctional sperm parameters evaluating their possible impact on fDNA. To accomplish this, MMP, degree of chromatin compactness, sperm apoptosis/vitality, fDNA, LP, and mitochondrial superoxide levels were evaluated by flow cytometry in a cohort of 874 men. A significant negative correlation was found between age and the percentage of alive spermatozoa (r = -0.75, p < 0.05). The percentage of spermatozoa with low MMP (L-MMP) correlated positively with the percentage of spermatozoa with abnormal chromatin compactness (r = 0.24, p < 0.05). Spermatozoa with abnormal chromatin compactness and L-MMP correlated negatively with the percentage of alive spermatozoa (r = 0.83, p < 0.05) and positively with spermatozoa with PS externalization (r = 0.13, p < 0.01). The percentage of alive spermatozoa correlated negatively with both the percentage of spermatozoa with PS externalization (r = 0.24, p < 0.01) and of the spermatozoa with fDNA (r = 0.10, p < 0.05). Spermatozoa with PS externalization correlated positively with the percentage of spermatozoa with fDNA (r = 0.09, p < 0.05). Spermatozoa with LP correlated positively with the percentage of spermatozoa with increased mitochondrial superoxide (r = 0.11, p < 0.01) In conclusion, these findings in a large number of men suggest that age, mitochondrial damage, and alteration of chromatin compactness could activate the apoptotic cascade which could result in an increased fDNA rate.

show abstract

Section: Discussioncontrasting

confidence: 74%

Bio-Functional Sperm Parameters: Does Age Matter?

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recent studies in lean subjects have provided inconsistent evidence, reporting both unchanged and increased Adiponectin levels after exercise. Nevertheless, it was demonstrated that Adiponectin has anti-diabetic, antiatherogenic, anti-inflammatory and insulinsensitizing properties (Weyer et al, 2001;Abbasi et al, 2004;Bastard et al, 2006;Sessa et al, 2019). Therefore, the identification of different strategies such as physical activity able to up-regulate the expression of Adiponectin and/or to enhance the action of Adiponectin could strongly contribute to mitigate or minimize metabolic dysfunctions.…”

Section: Introductionmentioning

confidence: 99%

The Important Role of Adiponectin and Orexin-A, Two Key Proteins Improving Healthy Status: Focus on Physical Activity

et al. 2020

Self Cite

View full text Add to dashboard Cite

Exercise represents the most important integrative therapy in metabolic, immunologic and chronic diseases; it represents a valid strategy in the non-pharmacological intervention of lifestyle linked diseases. A large body of evidence indicates physical exercise as an effective measure against chronic non-communicable diseases. The worldwide general evidence for health benefits are both for all ages and skill levels. In a dysregulated lifestyle such as in the obesity, there is an imbalance in the production of different cytokines. In particular, we focused on Adiponectin, an adipokine producted by adipose tissue, and on Orexin-A, a neuropeptide synthesized in the lateral hypothalamus. The production of both Adiponectin and Orexin-A increases following regular and structured physical activity and both these hormones have similar actions. Indeed, they improve energy and glucose metabolism, and also modulate energy expenditure and thermogenesis. In addition, a relevant biological role of Adiponectin and Orexin A has been recently highlighted in the immune system, where they function as immune-suppressor factors. The strong connection between these two cytokines and healthy status is mediated by physical activity and candidates these hormones as potential biomarkers of the beneficial effects induced by physical activity. For these reasons, this review aims to underly the interconnections among Adiponectin, Orexin-A, physical activity and healthy status. Furthermore, it is analyzed the involvement of Adiponectin and Orexin-A in physical activity as physiological factors improving healthy status through physical exercise.

show abstract

“…Finally, this design suggests several clinical research perspectives. In the next studies it will be interesting to evaluate if there are different levels of oxidative stress [43] capable of interfering on the validation of this equation and contextually evaluate the correlation with the quality of sexual activity [44], as well as compare aerobic exercise patterns vs other types of exercise.…”

Section: Discussionmentioning

confidence: 99%

Prediction equation for estimating cognitive function using physical fitness parameters in older adults

et al. 2020

Self Cite

View full text Add to dashboard Cite

Ageing is associated with declines in cognitive functions and physical fitness (PF). Physical exercise training and physical activity (PA) have been shown to have positive effects on cognitive functions and brain plasticity. This study aims to establish a practical equation for evaluating cognitive functions using PF parameters in healthy older adults. One-hundred and two older subjects were physically and clinically evaluated. Participants performed the Short Physical Performance Battery (SPPB) and handgrip test (HG); general cognitive functions were examined using the Mini Mental State Examination (MMSE). For all of them, a multiple regression analysis was used to predict MMSE from age, SPPB and HG variables. The new equation was cross validated to determine its prediction accuracy. Considering that SPPB and MMSE reference score are not different between genders, only one equation was developed for females and males. Age, SPPB and HG correlated significantly (p<0.01) with the MMSE score. The developed equation was MMSE = 19.479 + (1.548 x SPPB)-(0.130 x age) (R 2 = 0.72 and root mean square errors of 3.6). The results of PF are useful for exercise specialists to achieve the best physical exercise training and PA in older adults. In conclusion, this study showed for the first time that our new equation can be used to predict subjects' cognitive functions based on SPPB results and subject age. We suggest its use when patients' cognitive functions or more appropriate clinical tests cannot be pursued.

show abstract

Consequences on aging process and human wellness of generation of nitrogen and oxygen species during strenuous exercise

Cited by 16 publications

References 99 publications

Bio-Functional Sperm Parameters: Does Age Matter?

Bio-Functional Sperm Parameters: Does Age Matter?

The Important Role of Adiponectin and Orexin-A, Two Key Proteins Improving Healthy Status: Focus on Physical Activity

Prediction equation for estimating cognitive function using physical fitness parameters in older adults

Contact Info

Product

Resources

About