Consequences of urban pollution upon skin status. A controlled study in Shanghai area

Ma, Lefebvre; Dm, Pham; Boussouira, Boudiaf; Qiu, H.; C, Ye; Long, Xiaohui; Chen, R; Gu, W; Laurent, Anne-Marie; Nguyen, QL

doi:10.1111/ics.12270

Cited by 56 publications

(71 citation statements)

References 18 publications

(27 reference statements)

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“…The skin surface lipid (SSL) film, a mixture of sebum and keratinocyte membrane lipids, is the first barrier against environmental stress [134]. Among the ingredients of SSL, squalene, a key biosynthetic precursor of cholesterol secreted by SGs, and α-tocopherol (vitamin E) secreted together with lipids from sebaceous gland, provide collaboratively antioxidant protection to the skin surface [135][136][137]. In addition, the by-products, squalene peroxides, produce during squalene oxidation, are considered to be involved in inflammatory and immunologically determined skin diseases, such as acne, atopic and seborrheic dermatitis as well as in skin cancerogenesis [138].…”

Section: Sebaceous Glands and Skin Skin Detoxificationmentioning

confidence: 99%

“…In addition, the by-products, squalene peroxides, produce during squalene oxidation, are considered to be involved in inflammatory and immunologically determined skin diseases, such as acne, atopic and seborrheic dermatitis as well as in skin cancerogenesis [138]. A recent study in China showed that the urban polulation has a lower squalene/lipid ratio than the rural one, which may mean that reduction of squalene is induced by environmental pollutants [137]. Moreover, squalene peroxides are proposed as a reliable marker of environmental pollutants in the skin [138].…”

Section: Sebaceous Glands and Skin Skin Detoxificationmentioning

confidence: 99%

See 1 more Smart Citation

Beyond acne: Current aspects of sebaceous gland biology and function

Zouboulis¹,

Picardo

Qiang

et al. 2016

Rev Endocr Metab Disord

116

112

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The sebaceous gland is mostly found in association with a hair follicle. Its traditional function is the holocrine production of sebum, a complex mixture of lipids, cell debris, and other rather poorly characterized substances. Due to the gland central role in acne pathogenesis, early research had focused on its lipogenic activity. Less-studied aspects of the sebaceous gland, such as stem cell biology, the regulation of cellular differentiation by transcription factors, the significance of specific lipid fractions, the endocrine and specially the neuroendocrine role of the sebaceous gland, and its contribution to the innate immunity, the detoxification of the skin and skin aging have recently attracted the attention of researchers from different disciplines. Here, we summarize recent, multidisciplinary progress in sebaceous gland research and discuss how sebaceous gland research may stimulate the development of novel therapeutic strategies targeting specific molecular pathways of the pathogenesis of skin diseases.

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Section: Sebaceous Glands and Skin Skin Detoxificationmentioning

confidence: 99%

Section: Sebaceous Glands and Skin Skin Detoxificationmentioning

confidence: 99%

Beyond acne: Current aspects of sebaceous gland biology and function

Zouboulis¹,

Picardo

Qiang

et al. 2016

Rev Endocr Metab Disord

116

112

View full text Add to dashboard Cite

show abstract

“…In this regard, it is of interest that: (i) greasy skin was reported to be more frequent in individuals living in a Chinese metropolitan area as compared with a nonpolluted area [7], (ii) in subsequent studies sebum levels were indeed found to be increased in individuals living in major cities with high pollution levels [8], and (iii) the sebum of these individuals was qualitatively altered [8]. Overall, these studies indicate the possibility that air pollution may contribute to the aggravation of acne vulgaris.…”

Section: Introductionmentioning

confidence: 99%

A Time-Series Study of the Effect of Air Pollution on Outpatient Visits for Acne Vulgaris in Beijing

Liu

Pan²,

Vierkötter³

et al. 2018

Skin Pharmacol Physiol

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Background/Aims: There is increasing evidence that exposure to air pollutants, including particulate matter (PM_2.5, PM₁₀), nitrogen dioxide (NO₂), and sulfur dioxide (SO₂), might aggravate preexisting skin diseases such as eczema and urticaria. Here we investigated if a possible link exists between air pollution and acne vulgaris. We assessed the association between ambient air pollutant concentrations and the number of visits of patients for acne vulgaris to a dermatological outpatient clinic in Beijing, China, from April 1, 2012 to April 30, 2014. Methods: In this time period, 59,325 outpatient visits were recorded because of acne vulgaris. Daily air pollution parameters for PM₁₀, PM_2.5, SO₂, and NO₂ were obtained from the Beijing Municipal Environmental Monitoring Center. Results: Increased concentrations of ambient PM_2.5, PM₁₀, and NO₂ were significantly associated with increased numbers of outpatient visits for acne vulgaris over the 2 years. These effects could be observed for NO₂ in a single-pollutant model and for PM_2.5, PM₁₀, and NO₂ in 2-pollutant models, which are closer to real-life exposure. Of note, these effects were specific because they were not observed for increased SO₂ concentrations, which even showed negative correlations in all test models. Conclusion: This study provides indirect evidence for a link between acne vulgaris and air pollution.

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“…As leaves of certain trees may be used as markers of aerial pollution, in addition to global air analysis , human hairs could also be considered, by analogy, as airborne pollution probes. From a practical viewpoint, comparing the presence of PM and/or metals present on the hair surface of subjects living in two very different environments (low vs. severely polluted) seems a pertinent and important approach, in line with the objective(s) of the skin studies previously mentioned .…”

Section: Discussionmentioning

confidence: 96%

Particulate matter adheres to human hair exposed to severe aerial pollution: consequences for certain hair surface properties

Galliano

Ye²,

Su³

et al. 2017

Intern J of Cosmetic Sci

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This work indicates that a very high amount (e.g. billions) of PM can be deposited on a full head of hair for subjects living in a severely aerially polluted environment. This process can be reproduced in vitro. In real-life, pollution has a strong impact on hair surface properties, leading to a modification of the visual aspect (loss of shine) and the alteration of hair surface (increase in friction force). This work may be used to pave the way for prevention and cleansing studies in the field of hair care.

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Consequences of urban pollution upon skin status. A controlled study in Shanghai area

Abstract: This study demonstrated a significant impact of the pollution upon the skin status, as illustrated by changes in superficial biochemical parameters and volunteers' perception.

Cited by 56 publications

References 18 publications

Beyond acne: Current aspects of sebaceous gland biology and function

Beyond acne: Current aspects of sebaceous gland biology and function

A Time-Series Study of the Effect of Air Pollution on Outpatient Visits for Acne Vulgaris in Beijing

Particulate matter adheres to human hair exposed to severe aerial pollution: consequences for certain hair surface properties

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