Consequences of the exposome to gestational diabetes mellitus

Rudge, Marilza Vieira Cunha; Alves, Fernanda; Hallur, Raghavendra L.S.; Oliveira, Rafael Guilen de; Vega, Sofía; Reyes, David Rafael Abreu; Floriano, Juliana Ferreira; Prudêncio, Caroline Baldini; Garcia, Gilberto J.; Reis, Fabiana V.D.S.; Emanueli, Costanza; Fuentes, Gonzalo; Cornejo, Marcelo; Toledo, Fernando; Valenzuela-Hinrichsen, Andrés; Guerra, Catalina; Grismaldo, Adriana; Valero, Paola; Barbosa, Angélica Mércia Pascon; Sobrevía, Luis

doi:10.1016/j.bbagen.2022.130282

Cited by 6 publications

(3 citation statements)

References 172 publications

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“…Clinical risk factors for GDM development require an understanding of disease pathways. Reducing the occurrence and consequences of GDM requires knowledge-based interventions that identify harmful effects of TSI ( 56 ) because of glucose intolerance. The negative impact on placental vasculature function with GDM and gestational diabesity has been reviewed ( 57 ).…”

Section: The Pregnancy Exposomementioning

confidence: 99%

“…Thrombotic lesions on the maternal surface or avascular villi with thrombi on the fetal side are representative malperfusion lesions. IPS may worsen as MPF triad diseases during pregnancy continue, such as those associated with gestational diabetes ( 56 , 57 , 95 ) or PIH ( 55 ). Increased risks for fetal brain injuries result, with or without coincident fetal growth restriction as a sonographic biomarker ( 96 ).…”

Section: Ischemic Placental Syndromementioning

confidence: 99%

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Interdisciplinary fetal-neonatal neurology training applies neural exposome perspectives to neurology principles and practice

Scher

2024

Front. Neurol.

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An interdisciplinary fetal-neonatal neurology (FNN) program over the first 1,000 days teaches perspectives of the neural exposome that are applicable across the life span. This curriculum strengthens neonatal neurocritical care, pediatric, and adult neurology training objectives. Teaching at maternal-pediatric hospital centers optimally merges reproductive, pregnancy, and pediatric approaches to healthcare. Phenotype–genotype expressions of health or disease pathways represent a dynamic neural exposome over developmental time. The science of uncertainty applied to FNN training re-enforces the importance of shared clinical decisions that minimize bias and reduce cognitive errors. Trainees select mentoring committee participants that will maximize their learning experiences. Standardized questions and oral presentations monitor educational progress. Master or doctoral defense preparation and competitive research funding can be goals for specific individuals. FNN principles applied to practice offer an understanding of gene–environment interactions that recognizes the effects of reproductive health on the maternal-placental-fetal triad, neonate, child, and adult. Pre-conception and prenatal adversities potentially diminish life-course brain health. Endogenous and exogenous toxic stressor interplay (TSI) alters the neural exposome through maladaptive developmental neuroplasticity. Developmental disorders and epilepsy are primarily expressed during the first 1,000 days. Communicable and noncommunicable illnesses continue to interact with the neural exposome to express diverse neurologic disorders across the lifespan, particularly during the critical/sensitive time periods of adolescence and reproductive senescence. Anomalous or destructive fetal neuropathologic lesions change clinical expressions across this developmental-aging continuum. An integrated understanding of reproductive, pregnancy, placental, neonatal, childhood, and adult exposome effects offers a life-course perspective of the neural exposome. Exosome research promises improved disease monitoring and drug delivery starting during pregnancy. Developmental origins of health and disease principles applied to FNN practice anticipate neurologic diagnoses with interventions that can benefit successive generations. Addressing health care disparities in the Global South and high-income country medical deserts require constructive dialogue among stakeholders to achieve medical equity. Population health policies require a brain capital strategy that reduces the global burden of neurologic diseases by applying FNN principles and practice. This integrative neurologic care approach will prolong survival with an improved quality of life for persons across the lifespan confronted with neurological disorders.

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Section: The Pregnancy Exposomementioning

confidence: 99%

Section: Ischemic Placental Syndromementioning

confidence: 99%

Interdisciplinary fetal-neonatal neurology training applies neural exposome perspectives to neurology principles and practice

Scher

2024

Front. Neurol.

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“…Risiken für die Entwicklung und Progression eines GDM sind unter anderem eine genetische Prädisposition der Mutter, ihr Lebensstil (Bewegung, Ernährung), ihr Body Mass Index (BMI) sowie ein höheres Alter [2,3]. Wissensbasierte Interventionen zum Exposom als Gesamtheit aller Umwelteinflüsse könnten dazu beitragen, das Auftreten und die unvorteilhaften Konsequenzen von GDM zu verhindern [4]. GDM ist mit negativen Folgen für Mutter und Kind assoziiert.…”

Section: Introductionunclassified

Körperliche Aktivität und gesunde Ernährung zur Prävention und Therapie des Gestationsdiabetes mellitus

Meuffels,

Levcenko,

Brinkmann

2024

B&G Bewegungstherapie und Gesundheitssport

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Zusammenfassung Einleitung Die Entstehung und Progression von Gestationsdiabetes mellitus (GDM) wird neben anderen Faktoren durch das Bewegungs- und Ernährungsverhalten der Mutter beeinflusst. Evidenzbasierte Empfehlungen sind in der S3-Leitlinie GDM festgehalten. Ziel der Umfrage war es herauszufinden, ob schwangere Frauen über körperliche Aktivität und gesunde Ernährung von ihren FrauenärztInnen (FrÄ) aufgeklärt werden und ob sie sich ausreichend zu den Themen informiert fühlen. Methode Durch eine Online-Umfrage wurden schwangere Frauen (n=62) in Berlin mit und ohne GDM dazu befragt.Ergebnisse Lediglich circa die Hälfte der Befragten gab an, mit ihrer Gynäkologin/ihrem Gynäkologen überhaupt über körperliche Aktivität (52%) und gesunde Ernährung (45%) gesprochen zu haben. Weniger als die Hälfte aller Frauen (39%) war mit der Beratung zu den Themen körperliche Aktivität und Ernährung zufrieden. Fazit Die Beratung von Schwangeren durch ihre FrÄ zu den Themen Bewegung und gesunde Ernährung bei GDM besitzt den Ergebnissen zufolge deutliches Verbesserungspotenzial. Die Verbreitung von Schulungsmaterialien in gynäkologischen Praxen könnte sinnvoll sein.

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Traditional and 3D Stem Cell Cultures Maintained in Xenobiotic-Free Conditions: Immunological Aspects

Sakalem,

Brand,

dos Santos

et al. 2024

Comprehensive Hematology and Stem Cell Research

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Consequences of the exposome to gestational diabetes mellitus

Cited by 6 publications

References 172 publications

Interdisciplinary fetal-neonatal neurology training applies neural exposome perspectives to neurology principles and practice

Interdisciplinary fetal-neonatal neurology training applies neural exposome perspectives to neurology principles and practice

Körperliche Aktivität und gesunde Ernährung zur Prävention und Therapie des Gestationsdiabetes mellitus

Traditional and 3D Stem Cell Cultures Maintained in Xenobiotic-Free Conditions: Immunological Aspects

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