Consequences of a multi-generation exposure to uranium on Caenorhabditis elegans life parameters and sensitivity

Goussen, Benoit; Parisot, Florian; Beaudouin, Rémy; Dutilleul, Morgan; Buisset-Goussen, Adeline; Péry, Alexandre R.R.; Bonzom, Jean‐Marc

doi:10.1007/s10646-013-1078-5

Cited by 23 publications

(22 citation statements)

References 55 publications

(57 reference statements)

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“…Sixteen-generation studies on the effect of uranium to C. elegans found adaptation to exposure conditions for both exposed and control populations. Observed effects on fecundity were consistent between population treatments, whereas in one of the studies effects on body length showed differential evolution over the exposure duration once maternal effects diminished [15,16].…”

Section: Introductionmentioning

confidence: 77%

Multigenerational exposure to silver ions and silver nanoparticles reveals heightened sensitivity and epigenetic memory inCaenorhabditis elegans

et al. 2016

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The effects from multigenerational exposures to engineered nanoparticles (ENPs) in their pristine and transformed states are currently unknown despite such exposures being an increasingly common scenario in natural environments. Here, we examine how exposure over 10 generations affects the sensitivity of the nematode Caenorhabditis elegans to pristine and sulfidized Ag ENPs and AgNO 3 . We also include populations that were initially exposed over six generations but kept unexposed for subsequent four generations to allow recovery from exposure. Toxicity of the different silver forms decreased in the order AgNO 3 , Ag ENPs and Ag 2 S ENPs. Continuous exposure to Ag ENPs and AgNO 3 caused pronounced sensitization (approx. 10-fold) in the F2 generation, which was sustained until F10. This sensitization was less pronounced for Ag 2 S ENP exposures, indicating different toxicity mechanisms. Subtle changes in size and lifespan were also measured. In the recovery populations, the sensitivity to Ag ENPs and AgNO 3 resulting from the initial multigenerational exposure persisted. Their response sensitivity for all endpoints was most closely related to the last ancestral exposed generation (F5), rather than unexposed controls. The mechanisms of transgenerational transfer of sensitivity are probably organized through the epigenome, and we encourage others to investigate such effects as a priority for mechanistic toxicology.

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Section: Introductionmentioning

confidence: 77%

Multigenerational exposure to silver ions and silver nanoparticles reveals heightened sensitivity and epigenetic memory inCaenorhabditis elegans

et al. 2016

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“…Tanaka and Tatsuta 2013) or other pollutants (e.g. Muyssen et al 2005;Agra et al 2010), and involved Daphnia or other organisms (Carriere et al 1994;Goussen et al 2013) as model systems.…”

Section: Evolutionary Potential For Carbaryl Tolerancementioning

confidence: 99%

Experimental evolution reveals high insecticide tolerance in Daphnia inhabiting farmland ponds

Jansen

Coors

Vanoverbeke

et al. 2015

Evolutionary Applications

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Exposure of nontarget populations to agricultural chemicals is an important aspect of global change. We quantified the capacity of natural Daphnia magna populations to locally adapt to insecticide exposure through a selection experiment involving carbaryl exposure and a control. Carbaryl tolerance after selection under carbaryl exposure did not increase significantly compared to the tolerance of the original field populations. However, there was evolution of a decreased tolerance in the control experimental populations compared to the original field populations. The magnitude of this decrease was positively correlated with land use intensity in the neighbourhood of the ponds from which the original populations were sampled. The genetic change in carbaryl tolerance in the control rather than in the carbaryl treatment suggests widespread selection for insecticide tolerance in the field associated with land use intensity and suggests that this evolution comes at a cost. Our data suggest a strong impact of current agricultural land use on nontarget natural Daphnia populations.

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“…The exposure concentration and internal concentration of the organisms are related throughout time by a toxicokinetic model. The DEBtox models are toxicokinetic-toxicodynamic models (TK-TD) and have proved their reliability in the analysis of data from growth and reproduction tests (Péry et al 2002;Jager et al 2004;Goussen et al 2013). These models also allow estimating a no effect concentration (NEC) which is a threshold for toxicity that does not depend on the time of exposure.…”

Section: Introductionmentioning

confidence: 99%

An energy-based model to analyze growth data of earthworms exposed to two fungicides

Bart

Pelosi

Nélieu

et al. 2019

Environ Sci Pollut Res

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The pesticide risk assessment for earthworms is currently performed using standardized tests, the model species Eisenia fetida, and the analyses of the data obtained are performed with ad hoc statistical tools. We assessed the impact of two fungicides on the entire growth pattern of the earthworm species Aporrectodea caliginosa, which is highly representative of agricultural fields. Individuals of three different ages (from hatching to 56 days old) were exposed to Cuprafor micro ® (copper oxychloride) and Swing ® Gold (dimoxystrobin and epoxiconazole). Data were analyzed with an energy-based toxicodynamic model coupled with a toxicokinetic model. The copper fungicide caused a drastic growth inhibition once the No Effect Concentration (NEC), estimated at 65 mg kg-1 of copper, was exceeded. The Swing ® Gold negatively affected the growth with NEC values estimated at 0.387 mg kg-1 and 0.128 mg kg-1 for the dimoxystrobin and the epoxiconazole in this fungicide formulation, respectively. The time-profile of the effects on A. caliginosa individuals was fully accounted for by the model, whatever their age of exposure. Furthermore, toxicity data analyses, supported by measurements of fungicide concentrations in earthworm at the end of the experiment, allowed bettering understanding of the mechanisms of action of the fungicides towards earthworm growth.

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Consequences of a multi-generation exposure to uranium on Caenorhabditis elegans life parameters and sensitivity

Cited by 23 publications

References 55 publications

Multigenerational exposure to silver ions and silver nanoparticles reveals heightened sensitivity and epigenetic memory inCaenorhabditis elegans

Multigenerational exposure to silver ions and silver nanoparticles reveals heightened sensitivity and epigenetic memory inCaenorhabditis elegans

Experimental evolution reveals high insecticide tolerance in Daphnia inhabiting farmland ponds

An energy-based model to analyze growth data of earthworms exposed to two fungicides

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