Consequences for the Elderly After COVID-19 Isolation: FEaR (Frail Elderly amid Restrictions)

Briguglio, Matteo; Giorgino, R; Dell’Osso, Bernardo; Cesari, Matteo; Porta, Mauro; Lattanzio, Fabrizia; Banfi, Giuseppe; Peretti, G.

doi:10.3389/fpsyg.2020.565052

Cited by 55 publications

(80 citation statements)

References 39 publications

(41 reference statements)

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“…Aging is intrinsically associated with dietary impoverishment, musculoskeletal involution, restlessness, and progressive reduction of the ability to cope with physical and psychological stress factors [ 90 , 91 ]. This reduced resilience tends to worsen during prolonged hospitalization, resulting in the so-called hospital-associated deconditioning [ 92 , 93 ].…”

Section: Resultsmentioning

confidence: 99%

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Nutritional Orthopedics and Space Nutrition as Two Sides of the Same Coin: A Scoping Review

Briguglio

2021

Nutrients

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Since the Moon landing, nutritional research has been charged with the task of guaranteeing human health in space. In addition, nutrition applied to Orthopedics has developed in recent years, driven by the need to improve the efficiency of the treatment path by enhancing the recovery after surgery. As a result, nutritional sciences have specialized into two distinct fields of research: Nutritional Orthopedics and Space Nutrition. The former primarily deals with the nutritional requirements of old patients in hospitals, whereas the latter focuses on the varied food challenges of space travelers heading to deep space. Although they may seem disconnected, they both investigate similar nutritional issues. This scoping review shows what these two disciplines have in common, highlighting the mutual features between (1) pre-operative vs. pre-launch nutritional programs, (2) hospital-based vs. space station nutritional issues, and (3) post-discharge vs. deep space nutritional resilience. PubMed and Google Scholar were used to collect documents published from 1950 to 2020, from which 44 references were selected on Nutritional Orthopedics and 44 on Space Nutrition. Both the orthopedic patient and the astronaut were found to suffer from food insecurity, malnutrition, musculoskeletal involution, flavor/pleasure issues, fluid shifts, metabolic stresses, and isolation/confinement. Both fields of research aid the planning of demand-driven food systems and advanced nutritional approaches, like tailored diets with nutrients of interest (e.g., vitamin D and calcium). The nutritional features of orthopedic patients on Earth and of astronauts in space are undeniably related. Consequently, it is important to initiate close collaborations between orthopedic nutritionists and space experts, with the musculoskeletal-related dedications playing as common fuel.

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Section: Resultsmentioning

confidence: 99%

“…Limited access to visitors, role changes, and relocation have been known for decades to increase loneliness [ 103 ]. The sensorial deprivation due to limited interactions outside of the room exposes the old man to delirium along with age-associated spatial disorientation, disequilibrium, and drug-aggravated cognitive decline [ 90 , 104 ].…”

Section: Resultsmentioning

confidence: 99%

Nutritional Orthopedics and Space Nutrition as Two Sides of the Same Coin: A Scoping Review

Briguglio

2021

Nutrients

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“…A direct speculation is that staying home during lockdown, as a preventive measure to counteract SARS‐CoV‐2 outbreak, greatly limits sun exposure and has consequences on vitamin D synthesis and 25(OH)D levels in the whole population, regardless of age 43,47,98,185,186 . Such a worsening of vitamin D status may in turn affect the rate of infection and, possibly, increase the incidence of symptoms.…”

Section: Discussionmentioning

confidence: 99%

Is there a link between vitamin D status, SARS‐CoV‐2 infection risk and COVID‐19 severity?

Ferrari

Locatelli²,

Briguglio

et al. 2020

Cell Biochemistry & Function

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The outbreak of COVID‐19 emerged in December 2019 rapidly spread across the globe and has become pandemic. Little is known about the protective factors of this infection, which is equally distributed between genders and different ages while severe and poor prognosis cases are strongly associated to old males and the presence of comorbidities. Thus, preventive measures aiming at reducing the number of infection and/or their severity are strongly needed. Vitamin D has got great attention and has been claimed as potentially protective against the infection since it may be associated with immunocompetence, inflammation, aging, and those diseases involved in determining the outcomes of COVID‐19. This narrative review aims at collecting the literature available on the involvement of the vitamin D status in the pathogenesis of COVID‐19 and the putative utility of vitamin D supplementation in the therapeutics. It emerges that a poor vitamin D status seems to associate with an increased risk of infection whereas age, gender and comorbidities seem to play a more important role in COVID‐19 severity and mortality. While randomized control trials are needed to better inquire into this topic, vitamin D supplementation may be useful beside its potential effects on SARS‐CoV‐2 infection and COVID‐19.

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“…It is therefore reasonable to say that any previous hypoxic/vascular condition, cardiac inflammation, or autonomic dysfunction has to be recognized as a risk factor for COVID-19 onset and cardiovascular disease progression in any individual infected with SARS-CoV-2. Notably, the highest case/fatality ratio in older adults might be due to the increasing prevalence of frailty and comorbid cardiovascular diseases in advanced age (Briguglio et al, 2020b;Moccia et al, 2020), which is known to be associated with increased ACE/ACE2 ratio (Wang et al, 2016). While it is still controversial whether RAAS inhibitors are to FIGURE 1 | Representation of the cardiovascular derangements of coronavirus disease 2019 (COVID-19) that are due to either direct cellular damage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or indirect consequences of the exaggerated host's response.…”

Section: Preexisting Cardiovascular Conditions As Virulence Factor: Imentioning

confidence: 99%

SARS-CoV-2 Aiming for the Heart: A Multicenter Italian Perspective About Cardiovascular Issues in COVID-19

et al. 2020

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Consequences for the Elderly After COVID-19 Isolation: FEaR (Frail Elderly amid Restrictions)

Cited by 55 publications

References 39 publications

Nutritional Orthopedics and Space Nutrition as Two Sides of the Same Coin: A Scoping Review

Nutritional Orthopedics and Space Nutrition as Two Sides of the Same Coin: A Scoping Review

Is there a link between vitamin D status, SARS‐CoV‐2 infection risk and COVID‐19 severity?

SARS-CoV-2 Aiming for the Heart: A Multicenter Italian Perspective About Cardiovascular Issues in COVID-19

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