SARS-CoV-2 Aiming for the Heart: A Multicenter Italian Perspective About Cardiovascular Issues in COVID-19

Briguglio, Matteo; Porta, Mauro; Zuffada, Francesca; Bona, Alberto; Crespi, Tiziano; Pino, Fabio; Perazzo, Paolo; Mazzocchi, Marco; Giorgino, R; Angelis, Giuseppe De; Ielasi, Alfonso; Blasio, Giuseppe De; Turiel, M.

doi:10.3389/fphys.2020.571367

Cited by 13 publications

(15 citation statements)

References 156 publications

(176 reference statements)

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“…Antithrombin III is known to be crucial for heparin activity and Xa binding, and low circulating levels are associated with a high risk of thromboembolic events. Still, there is no consensus about the proper pharmacological therapy for COVID-19, but narrow indications support the use of high pharmacological doses of LMWH and treatment with hyperimmune serums (24)(25)(26).…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Severe COVID-19 Patients Admitted to an Intensive Care Unit in Lombardy During the Italian Pandemic

et al. 2021

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Italy was one of the worst affected European countries during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. More than 50% of Italian cases occurred in the northern region of Lombardy, where the saturation of health services between March and April 2020 forced hospitals to allocate patients according to available resources. Eighteen severe coronavirus disease 2019 (COVID-19) patients were admitted to our hospital needing intensive support. Given the disease fatality, we investigated the patients' characteristics to identify mortality predictors. We counted seven deaths from multiple organ failure, two from septic shock, and two from collapsed lungs. The maximum case fatality was observed in patients who contracted SARS-CoV-2 in hospitals. The fatal outcome was associated with the following baseline characteristics: polymorbidity (OR 2.519, p = 0.048), low body mass index (OR 2.288, p = 0.031), low hemoglobin (OR 3.012, p = 0.046), and antithrombin III (OR 1.172, p = 0.048), along with a worsening of PaO2/FiO2 ratio in the first 72 h after admission (OR 1.067, p = 0.031). The occurrence of co-infections during hospitalization was associated with a longer need for intensive care (B = 4.511, p = 0.001). More information is needed to inform intensive care for patients with severe COVID-19, but our findings would certainly contribute to shed some light on this unpredictable and multifaceted disease.

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Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Severe COVID-19 Patients Admitted to an Intensive Care Unit in Lombardy During the Italian Pandemic

et al. 2021

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“…The myocardium is innervated by sympathetic and vagal parasympathetic nerve fibers. The wide expression of ACE2 in nerve tissues and the neurotropic nature of SARS-CoV-2 could make the cardiac nerve fibers a favorite prey (7). Previous reports regarding COVID-19-induced bradycardia have shown that the usefulness of a permanent pacemaker differs among cases (3,4,8,9).…”

Section: Discussionmentioning

confidence: 99%

Paroxysmal Atrioventricular Block in a Relatively Young Patient with COVID-19

et al. 2021

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Cardiac involvement has been reported in patients with COVID-19. We herein report a 41-year-old man who presented with recurrent paroxysmal atrioventricular block without showing significant cardiac injuries or comorbidities. The patient was diagnosed with COVID-19 and admitted to our hospital, where he was noted to have paroxysmal atrioventricular block. Cardiac biomarkers, echocardiography, and cardiac magnetic resonance imaging findings were fairly normal. An endomyocardial biopsy performed before the implantation of a permanent pacemaker revealed mild myocardial fibrosis without inflammatory infiltrates. The unusual myocardial involvement of the novel coronavirus was suspected.

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“… 33 Additionally, upon the rupture of epithelial cells, SARS-CoV-2 can have an immense effect on the capillary system of the lung endothelial cells, which will cause a diffusion of a large amount of plasma components in the alveolar cavity. 34 On the other hand, the unrestrained virus infection caused by macrophage penetration which will lead to more injuries in the lungs. Simultaneously, the direct infection on other organs by this virus can cause systemic cytokine disturbance in the flow of immune pathogenesis.…”

Section: Overview Of Human Coronavirus Infectionsmentioning

confidence: 99%

Public health management during COVID-19 and applications of point-of-care based biomolecular detection approaches

Dastidar

Roy

2021

Environmental and Health Management of Novel Coronavirus Disease (COVID-19 )

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SARS-CoV-2 Aiming for the Heart: A Multicenter Italian Perspective About Cardiovascular Issues in COVID-19

Cited by 13 publications

References 156 publications

Clinical Characteristics of Severe COVID-19 Patients Admitted to an Intensive Care Unit in Lombardy During the Italian Pandemic

Clinical Characteristics of Severe COVID-19 Patients Admitted to an Intensive Care Unit in Lombardy During the Italian Pandemic

Paroxysmal Atrioventricular Block in a Relatively Young Patient with COVID-19

Public health management during COVID-19 and applications of point-of-care based biomolecular detection approaches

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