Consequence on Treatment of TB Patients Affected by HIV/AIDS A Conceptual Research

Uddin, Sarder Nasir; Hossain, Shamim; Huda, Md. Nurul; Rahman, Md. Asadur; Ali, Eunüs S.

doi:10.3844/ajidsp.2006.210.218

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…"TB is, thus, the leading cause of mortality in people with HIV/AIDS, and HIV contributes to a substantial proportion of tuberculosis deaths" (Chaisson & Churchyard, 2010). Globally, every year more than 8-9 million people are newly infected (Uddin et al, 2006). Therefore, in 1995, the World Health Organization launched the Directly Observed Treatment Short-course (DOTS) strategy for control of TB (WHO, 2006).…”

Section: Introductionmentioning

confidence: 99%

The Median Time to Develop Recurrent Tuberculosis at a Tertiary Hospital in Kota Bharu, Kelantan, Malaysia

Naing¹,

Rusli²,

Zuki³

et al. 2016

J App Pharm Sci

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Records of 114 recurrent TB patients from 1/1/2003-31/12/2009 were analyzed. Kaplan-Meier analysis was used to examine the median time for recurrence of TB. The overall median time to develop TB recurrence in registered TB recurrent patients was six months [95%CI: 4.58, 7.42] after the previous episode. It was found that recipients of Streptomycin (S), Isoniazid (H) and Rifampicin (R) twice weekly (S2H2R2) drug regimen [p=0.026] or daily HR drug regimen [p=0.049] during the continuation phase took a longer duration to develop recurrent TB than nonrecipients of these medicines by Kaplan-Meier analysis. Moreover, there also existed a significant time difference [P = 0.006] between the defaulters and non-defaulters of treatment to develop recurrent TB. Patients should take the complete course of therapy, to reduce recurrent TB infection. The drug regimens must contain the two most potent first line drugs Isoniazid [H] and Rifampicin [R] during the continuation phase.

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Section: Introductionmentioning

confidence: 99%

The Median Time to Develop Recurrent Tuberculosis at a Tertiary Hospital in Kota Bharu, Kelantan, Malaysia

Naing¹,

Rusli²,

Zuki³

et al. 2016

J App Pharm Sci

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Tuberculosis treatment survival of HIV positive TB patients on directly observed treatment short-course in Southern Ethiopia: A retrospective cohort study

Shaweno

Worku

2012

BMC Res Notes

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BackgroundTuberculosis (TB) and HIV co-infection remains a major public health problem. In spite of different initiatives implemented to tackle the disease, many countries have not reached TB control targets. One of the major attributing reasons for this failure is infection with HIV. This study aims to determine the effect of HIV infection on the survival of TB patients.FindingsA retrospective cohort study was employed to compare the survival between HIV positive and HIV negative TB patients (370 each) during an eight month directly observed treatment short-course (DOTS) period. TB patient’s HIV status was considered as an exposure and follow up time until death was taken as an outcome. All patients with TB treatment outcomes other than death were censored, and death was considered as failure. Cox proportional hazard regression model was used to determine the hazard ratio (HR) of death for each main baseline predictor. TB/HIV co-infected patients were more likely to die; adjusted Hazard Rate (AHR) =1.6, 95%CI (1.01, 2.6) during the DOTS period. This risk was statistically higher among HIV patients during the continuation phase (p=0.0003), as a result HIV positive TB patients had shorter survival (Log rank test= 6.90, df= 2, p= 0.008). The adjusted survival probability was lower in HIV positive TB patients (< 15%) than HIV negative TB patients (> 85%) at the end of the DOTS period (8th month).ConclusionTB treatment survival was substantially lower in HIV infected TB patients, especially during the continuation phase. Targeted and comprehensive management of TB/HIV with a strict follow up should be considered through the entire TB treatment period.

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Impact of Human Immune Deficiency Virus and Acquired Immune Deficiency Syndrome on Farm Households

Austin¹

2011

American Journal of Infectious Diseases

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Problem statement:The impact of HIV/AIDS in Africa cut across all sectors of human development and it poses serious challenge to the survival of several vulnerable poor, whose livelihood depends solely on agriculture. This study is an attempt to contribute to the understanding of HIV/AIDS by investigating household vulnerablity and its impact on production variability in farm households. Approach: A total of 110 households were involved inthe study split into households with and without infection. Data analysis involved the use of descriptive statistics and the estimation of the stochastic frontier model. Results: The vulnerability factors showed that 10.12% of the households were vulnerable to HIV. The important indices of vulnerability include non-use of condoms and having multiple sex partners. Farm size, labour and education were significant and positive determinants of productivity variability in both households. Access to credit had a positive effect on productivity in households with infection and impacted negatively on households without infection. Conclusion: Households with infection were grossly inefficient compared to households without infection. The mean economic efficiency in households with infection is 49% against 79% in households without infection. The policy outcome of the study is to equip Primary Health Centre's (PHC) and re-structural extension services to be more goal-driven.

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Consequence on Treatment of TB Patients Affected by HIV/AIDS A Conceptual Research

Cited by 3 publications

References 24 publications

The Median Time to Develop Recurrent Tuberculosis at a Tertiary Hospital in Kota Bharu, Kelantan, Malaysia

The Median Time to Develop Recurrent Tuberculosis at a Tertiary Hospital in Kota Bharu, Kelantan, Malaysia

Tuberculosis treatment survival of HIV positive TB patients on directly observed treatment short-course in Southern Ethiopia: A retrospective cohort study

Impact of Human Immune Deficiency Virus and Acquired Immune Deficiency Syndrome on Farm Households

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