Consensus report from the Food Allergy Research &amp; Education (FARE) 2019 Oral Immunotherapy for Food Allergy Summit

Pepper, Amber N.; Assa’ad, Amal; Blaiss, Michael S.; Brown, Emily; Chinthrajah, Sharon; Ciaccio, Christina E.; Fasano, Mary Beth; Gupta, Ruchi S.; Hong, Nurry; Lang, David M.; Mahr, Todd A.; Malawer, Erin; Roach, Anita; Shreffler, Wayne G.; Sicherer, Scott H.; Vickers, Kathleen; Vickery, Brian P.; Wasserman, Richard L.; Yates, Kimberley; Casale, Thomas B.

doi:10.1016/j.jaci.2020.05.027

Cited by 52 publications

(50 citation statements)

References 23 publications

(31 reference statements)

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“…OIT may not be suitable for every patient, and a shared decision-making strategy involving the patient, family, and physician is necessary. 14 Identifying the goals of the patient and family in undertaking treatment can help start the conversation. Most patients and families seeking food allergy treatment do not want the allergen to be eaten freely.…”

Section: Clinical Oit Procedures Identification Of Oit Candidatesmentioning

confidence: 99%

“…Additional precautions should be taken when using non-FDAapproved peanut or other food allergen products as OIT. 14 Unlike a quality-controlled, pharmaceutical grade product such as Palforzia, food products may vary in protein content of specific allergens and manufacturing processes can change at any time. 53,54 Packaging should be examined each time to verify ingredients and amount of protein, and to check for advisory labels.…”

Section: Home Dosingmentioning

confidence: 99%

“…Food allergy immunotherapy guidelines have been published by the European Academy of Allergy and Clinical Immunology and the Canadian Society of Allergy and Clinical Immunology, as well as a US consensus report from the Food Allergy Research and Education Oral Immunotherapy for Food Allergy Summit. [12][13][14] In this review, we will summarize recent data on food allergy treatments in the context of outlining a practical guide to administering OIT in the office.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Integrating oral immunotherapy into clinical practice

Leonard

Laubach

Wang

2021

Journal of Allergy and Clinical Immunology

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Section: Clinical Oit Procedures Identification Of Oit Candidatesmentioning

confidence: 99%

Section: Home Dosingmentioning

confidence: 99%

mentioning

confidence: 99%

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Integrating oral immunotherapy into clinical practice

Leonard

Laubach

Wang

2021

Journal of Allergy and Clinical Immunology

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“…Several guidelines and consensus regarding OIT for IgE-mediated food allergies have been published in recent years [22,[52][53][54][55], but standardized protocols have not been established, except for peanut OIT.…”

Section: Indication Of Patients Undergoing Oit For CMmentioning

confidence: 99%

Oral Immunotherapy for Children with Cow’s Milk Allergy

2021

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Cow’s milk allergy (CMA) is one of the most common IgE-dependent food allergies in children. Some children develop severe and persistent CMA, with near-fatal reactions after exposure to trace amounts of cow’s milk (CM). Because milk and dairy products are included in various processed food products, it is difficult to completely remove milk, which negatively affects the quality of life of children with CMA. Oral immunotherapy (OIT) can alleviate food allergen-induced anaphylaxis under continuous ingestion of a little of the causative food. Children with severe CMA may benefit from OIT, but the treatment requires a long time and poses a risk of anaphylaxis. Moreover, in recent years, new therapies, including omalizumab, sublingual immunotherapy, and epicutaneous immunotherapy, have played the role of optional OIT. In this review, we present the current methods of and other attempts at OIT, and discuss OIT for safely treating CMA.

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“…Food allergy is a growing worldwide public health problem affecting 5–10% of the population in developed nations [ 1 ]. It has a relevant effect on the well-being of patients and imposes a significant financial burden.…”

Section: Introductionmentioning

confidence: 99%

Detection of Allergenic Proteins in Foodstuffs: Advantages of the Innovative Multiplex Allergen Microarray-Based Immunoassay Compared to Conventional Methods

Tuppo

Giangrieco

Tamburrini

et al. 2022

Foods

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Several factors can affect the allergen content and profile of a specific food, including processing procedures often leading to a decrease in allergenicity, although no change, or even an increase, have also been reported. Evaluation of the effectiveness of a processing procedure requires the availability of reliable methodologies to assess the variation in molecules able to induce allergic reactions in the analyzed food. Conventional and innovative strategies and methodologies can be exploited to identify allergenic proteins in foodstuffs. However, depending on the specific purposes, different methods can be used. In this review, we have critically reviewed the advantages of an innovative method, the multiplex allergen microarray-based immunoassay, in the detection of allergens in foodstuffs. In particular, we have analyzed some studies reporting the exploitation of an IgE-binding inhibition assay on multiplex allergen biochips, which has not yet been reviewed in the available literature. Unlike the others, this methodology enables the identification of many allergenic proteins, some of which are still unknown, which are recognized by IgE from allergic patients, with a single test. The examined literature suggests that the inhibition test associated with the multiplex allergen immunoassay is a promising methodology exploitable for the detection of IgE-binding proteins in food samples.

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Consensus report from the Food Allergy Research & Education (FARE) 2019 Oral Immunotherapy for Food Allergy Summit

Cited by 52 publications

References 23 publications

Integrating oral immunotherapy into clinical practice

Integrating oral immunotherapy into clinical practice

Oral Immunotherapy for Children with Cow’s Milk Allergy

Detection of Allergenic Proteins in Foodstuffs: Advantages of the Innovative Multiplex Allergen Microarray-Based Immunoassay Compared to Conventional Methods

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