Consensus in Bladder Cancer Research Priorities Between Patients and Healthcare Professionals Using a Four-stage Modified Delphi Method

Bessa, Agustina; MacLennan, Steven; Enting, Deborah; Bryan, Richard T.; Josephs, Debra H.; Hughes, Simon; Amery, Suzanne; Khan, Muhammad Shamim; Malde, Sachin; Nair, Rajesh; Cahill, Fidelma; Wylie, Harriet; Thurairaja, Ramesh; Chatterton, Kathryn; Kinsella, Netty; Häggström, Christel; Hemelrijck, Mieke Van

doi:10.1016/j.eururo.2019.01.031

Cited by 26 publications

(17 citation statements)

References 3 publications

(2 reference statements)

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“…More specifically, we will run focus groups with patients with BC and their families, healthcare professionals, physiotherapists and behavioural scientist to help identify whether the results of the scoping review truly reflect the needs and expectations of all stakeholders involved. We will invite and recruit participants for this consultation phase through our ongoing collaborations with patient advocacy organisations and healthcare professional organisations (eg, Action Bladder Cancer UK, Fight Bladder Cancer, British Association of Urological Surgeons, British Uro-Oncology Group) 21…”

Section: Protocol Designmentioning

confidence: 99%

Scoping review protocol: is there a role for physical activity interventions in the treatment pathway of bladder cancer?

et al. 2019

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IntroductionPatients with bladder cancer (BC) have been found to have worse experiences than those with other cancers which may partly be due to impact on quality of life. Currently, little is known about the impact of physical activity (PA) on BC outcomes. This scoping review aims to identify what interventions are available, their reported efficacy and feasibility, and a description of potential underlying biological mechanisms for their effects.Methods and analysisPreferred Reporting Items for Systematic Reviews and Meta-Analyses Scoping Review (ScR) guidelines and the Levac methodology framework will be followed/used. Electronic databases will be searched (MEDLINE, EMBASE, the Cochrane Library, PsycInfo and Health, OpenGray). Two independent reviewers will screen all abstracts and titles and during a second stage and full-text publications for inclusion. All studies describing PA (as an existing lifestyle or as part of an intervention programme) during BC management will be included. Study characteristics will be recorded; qualitative data will be extracted and evaluated using the Donabedian framework. Quantitative data will be extracted and summarised. A further consultation step will be carried out with patients, their family members and healthcare professionals.Ethics and disseminationResults will be disseminated through a peer-reviewed publication. Through the consultation step, we will ensure that findings will reach a wide audience and recommendations can be made for future development of PA interventions for patients with BC. Data used will be from publicly available secondary sources, and the consultation step will be carried out as part of patient and public involvement so this study does not require ethical review.

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Section: Protocol Designmentioning

confidence: 99%

Scoping review protocol: is there a role for physical activity interventions in the treatment pathway of bladder cancer?

et al. 2019

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“…However, previous studies have demonstrated both increased and decreased survival associated with delay to RC. The impact of this delay on survival outcomes has recently been identified as one of the top ten unanswered research questions by BC patients and health care professionals thus highlighting the importance of studying this topic (8).…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review and Meta-analysis of Delay in Radical Cystectomy and the Effect on Survival in Bladder Cancer Patients

Russell

Liedberg

Khan

et al. 2020

European Urology Oncology

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“…Genomic and epigenomic approaches may thus inform the development of more accurate risk stratifiers and non-invasive diagnostics (19), tools that are urgently required by healthcare professionals and patients alike (20). CircRNAs also appear to have a role to play in this already complex setting as a novel class of prognostic biomarkers for NMIBC-in a pioneering study, Okholm et al (21) evaluated circRNAs in a large cohort (n = 457) of NMIBCs and identified circRNAs that are differently expressed between high and low risk tumors, highlighting two (circHIPK3 and circCDYL) as potential biomarkers (21).…”

Section: Introductionmentioning

confidence: 99%

Back-Splicing Transcript Isoforms (Circular RNAs) Affect Biologically Relevant Pathways and Offer an Additional Layer of Information to Stratify NMIBC Patients

et al. 2020

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Circularized transcript isoforms due to back-splicing are increasingly being reported in different tissues types and pathological states including cancer. Since these circular RNAs (circRNAs) are more stable than linear messenger RNA their identification and profiling in tumor tissue could aid in stratifying patients and may serve as biomarkers. In this study, we have investigated the relationship between circRNA expression and tumor grade in a cohort of 58, mostly non-muscle-invasive bladder cancer patients. From 4571 circRNAs detected, we identified 157 that were significantly differentially expressed between tumor grades relative to the linear transcript. We demonstrated that such grade-related differences can be identified in an independent cohort, and that a large fraction of circRNAs can be, in principle, detected in urine. The differentially expressed circRNAs cluster into subgroups according to their co-expression, subgroups which are enriched for DNA repair, cell cycle and intracellular signaling genes. Since one proposed function of circRNAs is to interfere with gene-regulation by acting as microRNA "sponges," candidates which were differentially expressed between tumor grades were investigated for potential miRNA target sites. By investigating the circRNAs from bladder cancer related pathways we demonstrated that the expression of these pathways, the circRNAs, and their parental genes are often decoupled and do not correlate, yet that some circRNAs do not follow this tendency. The present study provides the next step for the comprehensive evaluation of this novel class of RNAs in the context of non-muscle-invasive bladder cancer. Intriguingly, despite their possible function as microRNA sponges, they potentially affect host mRNA levels at the transcriptional stage, as compared to post-transcriptional control by miRNAs. Our analysis indicates differences of their activity between bladder cancer tumor stages, and their relative expression levels may provide an additional layer of information for patient stratification.

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Consensus in Bladder Cancer Research Priorities Between Patients and Healthcare Professionals Using a Four-stage Modified Delphi Method

Cited by 26 publications

References 3 publications

Scoping review protocol: is there a role for physical activity interventions in the treatment pathway of bladder cancer?

Scoping review protocol: is there a role for physical activity interventions in the treatment pathway of bladder cancer?

A Systematic Review and Meta-analysis of Delay in Radical Cystectomy and the Effect on Survival in Bladder Cancer Patients

Back-Splicing Transcript Isoforms (Circular RNAs) Affect Biologically Relevant Pathways and Offer an Additional Layer of Information to Stratify NMIBC Patients

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