Consensus guidelines for the management of atopic dermatitis: An <scp>A</scp>sia–<scp>P</scp>acific perspective

Rubel, Diana; Thirumoorthy, T; Soebaryo, Retno Widowati; Weng, Steven C. K.; Gabriel, Teresita M.; Villafuerte, Lillian L.; Chu, Chia‐Yu; Dhar, Sandipan; Parikh, Deepak; Wong, Li‐Chuen; Lo, K. K.

doi:10.1111/1346-8138.12065

Cited by 76 publications

(116 citation statements)

References 63 publications

(232 reference statements)

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“…43 At least 200-300 g of moisturizer cream per week is highly recommended. 44 One review suggested using urea-free softening cream after showers and a medium strength corticoid. 6 The clinical management of xerosis and/or pruritus in Singapore is summarized in Table 2.…”

Section: Management Of Xerosis And/or Pruritusmentioning

confidence: 99%

Management of epidermal growth factor receptor tyrosine kinase inhibitor‐related cutaneous and gastrointestinal toxicities

Tan

Chin

et al. 2017

Asia-Pac J Clncl Oncology

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Patients with advanced stage non-small cell lung cancer with sensitizing epidermal growth factor receptor (EGFR) mutations using EGFR tyrosine kinase inhibitors (TKIs) such as erlotinib, gefitinib and afatinib as first-line treatment had better progression-free survival, overall response rate and quality of life than those on chemotherapy. Although EGFR TKIs are commonly associated with skin-related (rash, xerosis and paronychia) and gastrointestinal-related (diarrhea and stomatitis) adverse events (AEs), these effects are usually mild. But severe cases can occur, significantly affecting patient's well-being, treatment compliance and quality of life. Therefore, patient education, early diagnosis, and prophylactic treatment are important strategies to optimally manage EGFR TKI-related adverse effects. In this review, we summarize the commonly encountered EGFR TKI-related AEs and provide a current overview of AE management in local practice with a focus on Asian patients. K E Y W O R D Sadverse drug events, gastrointestinal tract, mutations, non-small cell lung cancer, skin BACKGROUNDEighty percent of lung cancers are advanced-stage non-small cell lung cancer (NSCLC). (1) Epidermal growth factor receptor (EGFR) gene mutation, which is a major and potent oncogenic driver in NSCLC is a therapeutic target, with EGFR tyrosine kinase inhibitors (EGFR TKIs), altering the pattern of care in patients with advanced stage NSCLC.With EGFR TKIs (erlotinib, gefitinib and afatinib) as first-line treatment for patients with advanced stage NSCLC with sensitizing EGFR mutations, higher progression-free survival, overall response rate and quality of life than chemotherapy can be achieved. 1 These drugs are generally well tolerated as they have a predictable toxicity profile and less serious toxicities than traditional cytotoxic chemotherapy. 2 Nevertheless, EGFR TKIs can still produce severe adverse events (AEs) and impair quality of life.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. wileyonlinelibrary.com/journal/ajco 23

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Section: Management Of Xerosis And/or Pruritusmentioning

confidence: 99%

Management of epidermal growth factor receptor tyrosine kinase inhibitor‐related cutaneous and gastrointestinal toxicities

Tan

Chin

et al. 2017

Asia-Pac J Clncl Oncology

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“…В последние годы появилось достаточно публика-ций, касающихся лечения пробиотиками детей, боль-ных атопическим дерматитом [1,2,[11][12][13]. Показано, что кишечная микрофлора может модулировать имму-нологические и воспалительные системные реакции [11,12].…”

Section: таблица 2 клинические проявления острых кишечных инфекций (unclassified

“…В терапии атопического дерматита у детей пока-зали свою эффективность Lactobacillus rhamnosus GG, Lactobacillus plantarum, Lactobacillus acidophilus, Lactobacillus paracasei, Lactobacillus fermentum, Lactobacillus salivarius, Bifidobacterium lactis, Bifidobacterium breve [1,[11][12][13]. Учитывая негативное влияние атопичес-кого дерматита на течение и клинические проявле-ния острых кишечных инфекций у детей, подтверж-денную эффективность пробиотиков при лечении как инфекционных диарей, так и атопического дер-матита [1], их назначение в ситуации сочетанного те-чения обоих заболеваний представляется достаточно обоснованным.…”

Section: таблица 2 клинические проявления острых кишечных инфекций (unclassified

Particularly acute intestinal infections in children with atopic dermatitis. Case-control study

Халиуллина¹,

Анохин²

2016

Ross. vestn. perinatol. pediatr.

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Aim -determine the clinical and laboratory features of acute intestinal infection in children, occurring in conjunction with atopic dermatitis (AD).Material and methods. We conducted a study of «case-control», which included observation of 144 children hospitalized in the infectious hospital with a clinic of acute infectious diarrhea in the period from January to December 2012. In the study group were selected 72 children with atopic dermatitis clinic and acute infectious diarrhea in a couple of which, from the group of patients without burdened premorbid background were selected 72 «controls» matched by sex, age and etiology developed acute intestinal infection. The observation time was 5±2 days, which corresponds to the average length of stay of the child, patients with moderate forms of acute intestinal infection in the hospital. Results and discussion. About 2 times more often than in the control, acute intestinal infections in children with atopic dermatitis lesions were characterized by clinic middle and lower gastrointestinal -31.9% (CI 21,1-42,7) vs. 15.3% (CI 7-23 6), p =0.03. A number of bowel movements 6 or more times per day significantly more frequently observed in children with a combination of acute intestinal infections and atopic dermatitis -54.1% (CI 42,6-65,6) vs. 33.3% (CI 22,4-43.9) in the control), p =0.011. The duration of diarrhea was higher in the study group (Med 6 IQR 4-7 days and Med 5 IQR 3-6 days, respectively), p =0.046. The proportion of patients with high fever was also higher in the study group than in the controls -15.3% (CI 7-23,6) vs. 2,8% (CI 1-6,6), p =0.016. Conclusion. Acute intestinal infections in children with atopic dermatitis have a more pronounced clinical symptoms, which is characterized by clinic enterocolitis, severity and duration of diarrhea syndrome, usually accompanied by a high fever.

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“…Плацебо-контролируемыми клиническими иссле-дованиями было показано, что суммарный эффект применения топических ГКС или ингибиторов кальциневрина вносит основной вклад в улучшение состояния больных АтД. Дополнительное введение антибиотиков и/или антимикотиков лишь незначи-тельно улучшало динамику выздоровления [59][60][61][62][63]. С учетом риска развития устойчивости к антибио-тикам современные рекомендации по лечению АтД во всем мире предлагают ограничить использование противоинфекционной терапии.…”

Section: терапия аллергодерматозовunclassified

“…Включение антибактериальной терапии целесо-образно при распространенном процессе, явных признаках наличия той или иной инфекции и у больных, не отвечающих на базисную терапию [59][60][61]. В последнем случае применение антибиотиков и антимикотиков будет значимым в снижении реак-тивности иммунной реакции на повреждение кож-ного барьера (см.…”

Section: терапия аллергодерматозовunclassified

The role of infection in the pathogenesis of allergodermatoses

Svirshchevskaya¹,

Matushevskaya²,

Chudakov³

et al. 2015

Klin. dermatol. venerol.

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В обзоре представлены данные зарубежных и отечественных клинических исследований по изучению роли инфекции в патогенезе аллергодерматозов и влиянию микробной флоры на течение атопического дерматита (АтД). Даны общие сведения по микрофлоре кожи: нормальная, условно-патогенная и патогенная. Показано, что микробная флора кожи у значительной части больных аллергодерматозами вызывает осложнения в течении основного заболевания. Представлены механизмы контроля целостности барьеров организма млекопитающих, в частности, отмечена роль эпидермального барьера при ассоциации АтД и инфекции. Выделены основные направления в лечении аллергодерматозов, основанные на международных и российских клинических рекомендациях по лечению АтД. Определено место топических антибактериальных и комбинированных препаратов в терапии осложненных форм аллергодерматозов. Ключевые слова: аллергодерматозы, атопический дерматит, стафилококк, лимфоидные клетки врожденного иммунитета 2-го типа, топическая терапия, комбинированная терапия, Акридерм.The review presents the data of foreign and national clinical studies on the role of infection in the pathogenesis of allergodermatoses and the influence of the microbial flora on the course of atopic dermatitis. General information on the normal, opportunistic and pathogenic microflora of the skin is provided. It is shown that the microbial flora of the skin causes complications of an underlying disease in a significant proportion of patients with allergodermatoses. The control mechanisms of the integrity of the body's barriers in mammals are presented. In particular, the role of the epidermal barrier impairment on the association of atopic dermatitis and infection is discussed. The main directions in the treatment of allergodermatoses are described based on Russian and International Clinical Guidelines for the treatment of atopic dermatisis. The significance of topical antibacterial and combined drugs in the treatment of complicated allergodermatoses is defined.

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Consensus guidelines for the management of atopic dermatitis: An Asia–Pacific perspective

Cited by 76 publications

References 63 publications

Management of epidermal growth factor receptor tyrosine kinase inhibitor‐related cutaneous and gastrointestinal toxicities

Management of epidermal growth factor receptor tyrosine kinase inhibitor‐related cutaneous and gastrointestinal toxicities

Particularly acute intestinal infections in children with atopic dermatitis. Case-control study

The role of infection in the pathogenesis of allergodermatoses

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