Particularly acute intestinal infections in children with atopic dermatitis. Case-control study

Abstract

Aim -determine the clinical and laboratory features of acute intestinal infection in children, occurring in conjunction with atopic dermatitis (AD).Material and methods. We conducted a study of «case-control», which included observation of 144 children hospitalized in the infectious hospital with a clinic of acute infectious diarrhea in the period from January to December 2012. In the study group were selected 72 children with atopic dermatitis clinic and acute infectious diarrhea in a couple of which, from the group of patients without burdened premorbid background were selected 72 «controls» matched by sex, age and etiology developed acute intestinal infection. The observation time was 5±2 days, which corresponds to the average length of stay of the child, patients with moderate forms of acute intestinal infection in the hospital. Results and discussion. About 2 times more often than in the control, acute intestinal infections in children with atopic dermatitis lesions were characterized by clinic middle and lower gastrointestinal -31.9% (CI 21,1-42,7) vs. 15.3% (CI 7-23 6), p =0.03. A number of bowel movements 6 or more times per day significantly more frequently observed in children with a combination of acute intestinal infections and atopic dermatitis -54.1% (CI 42,6-65,6) vs. 33.3% (CI 22,4-43.9) in the control), p =0.011. The duration of diarrhea was higher in the study group (Med 6 IQR 4-7 days and Med 5 IQR 3-6 days, respectively), p =0.046. The proportion of patients with high fever was also higher in the study group than in the controls -15.3% (CI 7-23,6) vs. 2,8% (CI 1-6,6), p =0.016. Conclusion. Acute intestinal infections in children with atopic dermatitis have a more pronounced clinical symptoms, which is characterized by clinic enterocolitis, severity and duration of diarrhea syndrome, usually accompanied by a high fever.