Consensus for the diagnosis, prognosis and treatment of feline mammary tumors

Cassali, Geovanni Dantas; Campos, Cecília Bonolo de; Bertagnolli, Angélica Cavalheiro; Estrela‐Lima, Alessandra; Lavalle, Gleidice Eunice; Damasceno, Karine Araújo; Nardi, Andrigo Barboza Di; Cogliati, Bruno; Costa, Fernanda Vieira Amorim da; Sobral, Renata Afonso; Santis, Giovana Wingeter Di; Fernandes, Cristina Gevehr; Ferreira, Ênio; Salgado, Breno S.; Vieira-Filho, Carlos Humberto da Costa; Silva, Danielle Nascimento; Martins-Filho, Emanoel Ferreira; Teixeira, S.V.; Nunes, Fernanda Camargo; Nakagaki, Karen Yumi Ribeiro

doi:10.11606/issn.1678-4456.bjvras.2018.135084

Cited by 66 publications

(163 citation statements)

References 53 publications

(90 reference statements)

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“…The EGFR antibody detected a 170 kDa band in all samples, which is expected size of the receptor. The EGFR localization was also investigated in CMT that correspond to a less aggressive type of carcinoma in dogs [5, 7]. We have selected six cases of CMT (clinicopathological and survival data are shown in Table 2) that showed better overall survival than IMPC (IMPC, median 120 days; CMT, did not reach median survival; p=0.0017) (Graph 1.).…”

Section: Resultsmentioning

confidence: 99%

“…The five cases of IMPC evaluated in our study presented poor prognosis, high rates of lymph nodes metastasis, high tumor size and poor overall survival [12-14]. The EGFR is not present within the nucleus or in the INM in CMT, which has better prognosis than other malignant histological types [5, 7]. Bertagnolli, et al , 2011, and Ribeiro, et al , 2012, shown using histopathological analyses that in invasive areas of CMT the EGFR expression is decreased [1, 31].…”

Section: Discussionmentioning

confidence: 99%

“…All cases were reviewed and re-classified independently by two veterinary pathologists (COG and GDC). In brief, carcinomas with cystic formations containing nests of epithelial cells with a moruliform appearance (infiltrating micropapillary pattern), associated or not with ‘in situ’ micropapillary areas, were diagnosed as IMPC [5] (Figure 1A and 1B). The morphological criteria used for the diagnosis of the CMT lesions were proposed by Misdorp et al .…”

Section: Methodsmentioning

confidence: 99%

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Inner nuclear membrane localization of epidermal growth factor receptor (EGFR) in spontaneous canine model of invasive micropapillary carcinoma of the mammary gland

Rodrigues

Gamba

Faria

et al. 2016

Pathology - Research and Practice

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The epidermal growth factor receptor (EGFR) has been described in the nucleus of primary tumors. Accumulation of EGFR at the nucleus is linked to DNA synthesis and cell proliferation, but the pathological significance of nuclear EGFR is not completely understood. The aim of this study was to investigate the nuclear localization of EGFR in invasive micropapillary carcinoma (IMPC) that is an aggressive neoplasm of canine mammary gland. Confocal immunofluorescence of formalin and paraffin-embedded tissue was used to access the subcellular localization of EGFR. Our results demonstrated that EGFR co-localizes with the inner nuclear envelope marker, Lamin B1 in IMPC. Furthermore, EGFR was not localized within the nucleus or at the inner nuclear envelope membrane in mammary carcinoma in mixed tumor (CMT) that is associated with a better prognosis than other malignant histological types. This finding could be useful as a predictive biomarker of therapeutic response for IMPC.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Inner nuclear membrane localization of epidermal growth factor receptor (EGFR) in spontaneous canine model of invasive micropapillary carcinoma of the mammary gland

Rodrigues

Gamba

Faria

et al. 2016

Pathology - Research and Practice

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“…Os tumores de mama são frequentes em cadelas e representam aproximadamente 52% de todas as neoplasias nessa espécie, sendo que mais de 75% dos casos são considerados malignos (CASSALI et al, 2014).…”

Section: Introductionunclassified

Metástase De Carcinoma Mamário Em Sistema Nervoso Central De Cadela

Castro¹,

Gouveia²,

Silva³

et al. 2017

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RESUMOMetástases de carcinoma mamário podem ocorrer em vários tecidos, porém são incomuns no sistema neural. Objetivou-se relatar um caso de neoplasia mamária primária com metástase no cérebro, cerebelo, pulmão e linfonodo. O animal em questão era uma cadela da raça Shih-Tzu de sete anos de idade, com histórico de neoplasia mamária com recidiva após exérese cirúrgica. O diagnóstico da neoplasia mamária foi carcinoma tubular com êmbolos neoplásicos em vasos linfáticos e metástase em linfonodo. Após a exérese cirúrgica a cadela retornou para atendimento apresentando sintomatologia compatível com síndrome vestibular. Foi realizada a eutanásia e durante a necropsia observou-se massa no lobo caudal do pulmão direito, assim como aderência da dura-máter no osso temporal e occipital, na região do hemisfério cerebral direito e cerebelo, respectivamente. Após retirada do encéfalo e cerebelo verificou-se presença de duas massas localizadas no encéfalo e cerebelo, respectivamente. A massa localizada no encéfalo direito adentrava a substância branca, apresentava coloração pardacenta, bordas ligeiramente irregulares, medindo aproximadamente 2,5 cm de diâmetro, em contrapartida, a massa no cerebelo era elevada, brancacenta, de formato irregular, medindo aproximadamente 2,0 cm de diâmetro. Microscopicamente havia áreas multifocais, circunscritas, de proliferação de células epiteliais, formando ácinos, compatíveis com metástase de carcinoma mamário. As metástases pulmonares de carcinoma mamário são comuns, porém infrequentes no sistema neural. No caso em questão os sinais neurológicos apresentados pelo animal foram ocasionados pela metástase de carcinoma mamário reforçando a necessidade de diagnóstico precoce e acompanhamento de cadelas portadoras de tumores de mama, mesmo após a exérese cirúrgica. PALAVRAS-CHAVE: canino, disseminação, neoplasia mamária.

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“…More advanced tumours may require adjuvant therapy (Novosad 2003, Sorenmo 2003), and chemotherapy is often recommended for dogs with mammary tumours considered to be at risk for metastasis or recurrence (Sorenmo and others 2013). However, there is no standard recommendation for the use of chemotherapy (Cassali and others 2014). High-quality trials are needed to evaluate the efficacy of chemotherapy protocols as well as to provide guidance for treating high-risk mammary gland tumours (Sorenmo 2003, Sorenmo and others 2013).…”

Section: Introductionmentioning

confidence: 99%

Absence of significant adverse events following thalidomide administration in bitches diagnosed with mammary gland carcinomas

et al. 2016

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The aim of the study was to evaluate the incidence of adverse events (AEs) in female dogs diagnosed with advanced clinical stage mammary gland neoplasms following treatment with thalidomide. A prospective analysis of 29 female dogs treated with a high dose (HD) of 20 mg/kg/day of thalidomide for three months followed by a low dose (LD) of 10 mg/kg/day of thalidomide for three months was performed. All patients underwent physical examination, complete blood count, serum biochemistry profile, thoracic radiographs, and abdominal ultrasound analysis before the treatment and after the HD and LD. Clinical AEs were absent in 16/29 (55.17 per cent) patients following HD. An initial 3-5 day period of somnolence was described in 4/29 (13.79 per cent), prolonged somnolence in 5/29 (17.24 per cent), a short period of somnolence lasting only a few hours in 3/29 (10.34 per cent), and difficulty to rouse was described in 5/29 (17.24 per cent) cases. Two patients (6.89 per cent) presented with prolonged somnolence that interfered with activities of daily living, resulting in anticipation of the dose reduction to the proposed LD after 15 days of the HD treatment. Following dose reduction, AE improvement was observed in all patients. Albeit remaining within the reference ranges, erythrocytes, haematocrit, total leucocyte count, neutrophils, lymphocytes, monocytes and γ-glutamyltranspeptidase showed significant alteration associated to thalidomide treatment.

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Consensus for the diagnosis, prognosis and treatment of feline mammary tumors

Cited by 66 publications

References 53 publications

Inner nuclear membrane localization of epidermal growth factor receptor (EGFR) in spontaneous canine model of invasive micropapillary carcinoma of the mammary gland

Inner nuclear membrane localization of epidermal growth factor receptor (EGFR) in spontaneous canine model of invasive micropapillary carcinoma of the mammary gland

Metástase De Carcinoma Mamário Em Sistema Nervoso Central De Cadela

Absence of significant adverse events following thalidomide administration in bitches diagnosed with mammary gland carcinomas

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