Consensus Conference on Brain Tumor Definition for Registration

Abstract

The Consensus Conference on Brain Tumor Definition was facilitated by the Central Brain Tumor Registry of the United States and held on November 10, 2000, in Chicago, Illinois, to reach multidisciplinary agreement on a standard definition of brain tumors for collecting and comparing data in the U.S. The Brain Tumor Working Group, convened in 1998 to determine the status of brain tumor collection in the U.S., outlined 4 recommendations of which the first 2 guided the discussion for the Consensus Conference: (1) standardization of a definition of primary brain tumors that is based on site alone, rather than on site and behavior, and that can be used by surveillance organizations in collecting these tumors; and (2) development of a reporting scheme that can be used for comparing estimates of primary brain tumors across registries. Consensus was reached on the collection of all primary brain tumor histologies found and reported in the brain or CNS ICD-O site codes (C70.0-C72.9 and C75.1-C75.3), including those coded benign and uncertain as well as those coded malignant. In addition, a comprehensive listing of histologies occurring in the brain and CNS, based on the CBTRUS grouping scheme, was formulated to provide a template for reporting in accordance with the second recommendation of the Brain Tumor Working Group. With consensus achieved on the first 2 recommendations, the stage is set to move forward in estimating additional resources necessary for the collection of these tumors, including funding, training for cancer registrars, identifying quality control measures, and developing computerized edit checks, as outlined in the last 2 recommendations of the Brain Tumor Working Group.

Increasing incidence of central nervous system (CNS) tumors (2000–2012): findings from a population based registry in Gironde (France)

“…Tumors were classified by grouping five-digit histology codes from the International Classification of Diseases for Oncology, third edition , into broad histology subgroups based on the recommendations from the 2000 Consensus Conference on Brain Tumor Definition for Registration [ 30 ].…”

Innate immune functions of microglia isolated from human glioma patients

“…Patients' tumors (n = 50) were graded pathologically as glioblastoma multiforme by a neuropathologist according to the WHO classification [ 22 , 23 ]. Fresh normal brain tissue (n = 6) can only be rarely obtained since for most patients efforts are made by the neurosurgeon to preserve this tissue.…”

Descriptive epidemiology of CNS tumors in France: results from the Gironde Registry for the period 2000-2007

“…Since the recommendations of the International Agency for Research on Cancer at the end of the 1990s, 23 most registries have taken into account standardized reporting definitions and have started collecting data on tumors with benign or uncertain behavior as well as malignant tumors. 24,25 For these reasons, the 2000s represent the first decade where no major event created an artifactual increase in CNS tumor recording and offer the opportunity to obtain realistic data on incidence and trends for major histological subtypes. Getting high-quality and detailed data is critical for providing a good basis for etiological clues, since differences in age, sex, and other individual characteristics may be related to risk factors.…”