Descriptive epidemiology of CNS tumors in France: results from the Gironde Registry for the period 2000-2007

Abstract

An increase in the incidence of CNS tumors has been observed in many countries in the last decades. The reality of this trend has been much debated, as it has happened during a period when computer-assisted tomography and MRI have dramatically improved the detection of these tumors. The Gironde CNS Tumor Registry provides here the first data on CNS tumor incidence and trends in France for all histological types, including benign and malignant tumors, for the period 2000-2007. Incidence rates were calculated globally and for each histological subtype. For trends, a piecewise log-linear model was used. The overall annual incidence rate was found to be 17.6/100 000. Of this rate, 7.9/100 000 were neuroepithelial tumors and 6.0/100 000 were meningiomas. An overall increase in CNS tumor incidence was observed from 2000 to 2007, with an annual percent change (APC) of +2.33%, which was explained mainly by an increase in the incidence of meningiomas over the 8-year period (APC = +5.4%), and also more recently by an increase in neuroepithelial tumors (APC = +7.45% from 2003). The overall increase was more pronounced in women and in the elderly, with an APC peaking at +24.65% in subjects 85 and over. The increase in the incidence rates we observed may have several explanations: not only improvements in registration, diagnosis, and clinical practice, but also changes in potential risk factors.

Epidemiology of Primary CNS Tumors in Iran: A Systematic Review

“…However, the incidence of primary brain tumors in the US (Dolecek et al, 2012), Korea (Lee et al, 2010) and France (Baldi et al, 2011) is more frequent in females. This might be due to the higher rate of meningiomas (30.6% and 35%) and lower rates for gliomas (17% and 30%) in Korea and US, respectively.…”

“…For the first time, a CNS tumor registry was begun in 1902 by Harvey Cushing (Wahl et al, 2009) and subsequently the registry expanded to other countries. The epidemiologic data from 1 1 , Rashid Ramezani 5 such registries has been published in the US, Canada, France, Denmark, Norway, Finland, Sweden, Australia, India, Korea and Japan (Davis et al, 1999;Kaneko et al, 2002;Bauchet et al, 2007;Pirouzmand and Sadanand, 2007;Deltour et al, 2009;Lee et al, 2010;Baldi et al, 2011;Dobes et al, 2011;Manoharan et al, 2012).…”

Malignant Tumours of the Central Nervous System in Kazakhstan - Incidence Trends from 2004-2011

“…Increase primarily in the elderly and females has also been observed in France (Baldi et al, 2011), while rise in childhoods rates was reported for Canada (Rosychuk et al, 2012). In contrast the situation appears stable for the Nordic countries (Schmidt et al, 2011) The situation is complicated by the vaious types of CNS tumours whcih have independent risk factors.…”

Dietary and Alcohol Intake and Central Nervous System Tumors in Adults: Results of the CERENAT Multicenter Case-Control Study

“…ous intracranial tissues [1] . Whatever be the histological type, studies concerning the etiology of brain tumors remain globally inconclusive.…”

“…Other risk factors such as the use of pesticides, being exposed to electromagnetic fields, hormonal factors, infectious factors (such as herpes virus), smoking, alcohol consumption or diet have been hypothesized but without definitive conclusions [2,3,6] . A substantial increase in the incidence of these tumors has been observed in most countries in recent decades [1,7] , partially because of advanced diagnostic techniques, and also because of environmental and nutritional factors that may have a putative role [8] .…”