A 44-year-oldwoman with a history of cerebral palsy, intellectual disability, seizure disorder, and hypothyroidism was brought to the emergency department from her group home for increasing lethargy over the past day. At baseline she was bedbound, nonverbal, and did not follow commands. Her aide reported difficulty feeding her that morning. The patient's family had recently noted abnormal twitching movements and occasional lateral neck movements to the right during eating, which were unlike her usual seizures. Review of systems was otherwise negative. In the emergency department, she was hypothermic (T 95.3°F) and hypotensive (BP 73/54 mmHg) with a heart rate of 80 beats/min.The combination of hypotension and hypothermia brings to mind several possibilities, including sepsis, myxedema, or a central nervous system disorder affecting the hypothalamic pituitary axis, the area responsible for temperature regulation. The abnormal twitching movements could be a manifestation of her preexisting seizure disorder or possibly myoclonic jerks due to a toxic or metabolic process affecting the brain.The discussant quickly generates two differential diagnoses: one for hypotension and hypothermia and the other for abnormal twitching movements. This rapid generation of the differential diagnosis is characteristic of non-analytic reasoning or pattern recognition.The patient had a long-standing history of generalized tonic-clonic seizures occurring twice weekly on average. Three weeks ago she was hospitalized with hypothermia and hypotension, and was treated for a presumed urinary tract infection (UTI) (although cultures were negative). During that hospitalization she experienced an episode of status epilepticus, prompting addition of valproate to her anticonvulsant regimen. At that time, a morning serum cortisol level was 8.5 mcg/dL.Given her recent hospitalization, UTI or another infection could be responsible for her recurrent hypotension and hypothermia. However the negative urine culture calls into question the previous diagnosis of UTI. Noninfectious causes of hypotension and hypothermia, including adrenal insufficiency or hypothyroidism, are also possible. The serum cortisol level, while in the normal range, does not eliminate adrenal insufficiency from consideration, particularly since the patient is acutely ill (which should elevate cortisol levels). A normal response to adrenocorticotropic hormone (ACTH) administration would be preferred to exclude that diagnosis.After obtaining further data, the discussant uses analytic reasoning to interpret the normal cortisol level as relatively low in the setting of stress physiology. The cognitive psychology literature has described two types of thinking: non-analytic (i.e., fast, subconscious, intuitive) and analytic (i.e., slow, effortful, conscious). This dual process theory has been used to describe clinical reasoning. Experienced clinicians seamlessly transition between non-analytic and analytic reasoning in making diagnoses. Unfortunately, how clinicians apply and switch bet...