Connexin32 protects against vascular inflammation by modulating inflammatory cytokine expression by endothelial cells

“…Connexins have been reported to protect the organism against the cytokine-mediated inflammatory reaction of vascular endothelial cells [257], and it is assumed that cytokine therapy may be combined with a Connexin activation therapy in the future. Since ion channels have been shown to be actively involved, the mechanisms in cell-cell communication and immunology seem even more complicated: heparin sulphate (HS), a proteoglycan of the ECM, induces the membrane potassium channel (MaxiK) in the production of inflammatory cytokines [258].…”

Section: (4) Cell-cell Communication and Anticancer Treatmentmentioning

confidence: 99%

Cell-Cell Communication in the Tumor Microenvironment, Carcinogenesis, and Anticancer Treatment

Brücher

Jamall

2014

Cell Physiol Biochem

176

161

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The delineation of key molecular pathways has enhanced our knowledge of the biology of tumor microenvironment, tumor dissemination, and carcinogenesis. The complexities of cell-cell communication and the possibilities for modulation provide new opportunities for treating cancers. Cells communicate by direct and indirect signaling. Direct cell-cell communication involves both, self-self-communication (intracrine and autocrine), and adjacent communication with nearby cells (juxtacrine), which themselves are regulated by distinct pathways. Indirect intercellular communication involves local communication over short distances (paracrine and synaptic signaling) or over large distances via hormones (endocrine). The essential components of cell-cell communication involve communication junctions (Connexins, Plasmodesmata, Ion Channels, Chemical Synapses, and Pannexins), occluding junctions (Tight Junctions), and anchoring junctions (Adherens, Desmosomes, Focal Adhesions, and Hemidesmosomes). The communication pathways pass through junctions at physical cell-cell attachments, and they go, as well, through the extracellular matrix (ECM) via the different transmembrane adhesion proteins (Cadherins and Integrins). We have here reviewed cell-cell communication involving (1) the components of junctions and their dynamic interplay with the other aspects of communication, including (2) the tumor microenvironment and carcinogenesis, (3) coupling and migration, (4) the underlying cell-cell and sub-cellular communication mechanisms (signaling) of anticancer treatments, and finally, (5) aspects of recent research on cell-cell communication.

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“…Within the cells of the blood vessel wall, four connexins have been well characterized: Cx37, Cx40, Cx43, and Cx45. In addition, it was recently shown that Cx32 is expressed within vascular cells and may contribute to direct cell-to-cell communication through gap junctions (Okamoto et al, 2009(Okamoto et al, , 2011Fowler et al, 2013). Typically, ECs predominantly express Cx37, Cx40, and Cx43, whereas VSMCs have been shown to express Cx37, Cx43, and Cx45 (Johnstone et al, 2009a,b;Okamoto et al, 2009).…”

Section: A Gap Junction Channelsmentioning

confidence: 99%

Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall

et al. 2014

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Connexin32 protects against vascular inflammation by modulating inflammatory cytokine expression by endothelial cells

Cited by 32 publications

References 34 publications

Reciprocal Regulation between Proinflammatory Cytokine-induced Inducible NO Synthase (iNOS) and Connexin43 in Bladder Smooth Muscle Cells

Reciprocal Regulation between Proinflammatory Cytokine-induced Inducible NO Synthase (iNOS) and Connexin43 in Bladder Smooth Muscle Cells

Cell-Cell Communication in the Tumor Microenvironment, Carcinogenesis, and Anticancer Treatment

Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall

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