Connectivity of the Cingulate Sulcus Visual Area (CSv) in Macaque Monkeys

Castro, Vanessa De; Smith, Andrew T.; Beer, Anton; C, Leguen; Vayssière, Nathalie; Héjja-Brichard, Yseult; Audurier, Pauline; Cottereau, Benoit R.; Durand, Jean-Baptiste

doi:10.1093/cercor/bhaa301

Cited by 13 publications

(26 citation statements)

References 77 publications

(65 reference statements)

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“…Somatosensory information, presumably emphasising proprioception, is able to reach mCSv from somatosensory cortex via some combination of PEc, PE, PEci and area 31, and to reach human CSv via a comparable system including hPEc and hPE. Direct input from somatosensory cortex is also suggested by MRI connectivity in both species (Smith et al 2018;De Castro et al 2021). Surprisingly, perhaps, it is more difficult to say how visual and vestibular signals reach CSv.…”

Section: Sources Of Sensory Data For Csvmentioning

confidence: 99%

“…Two further multisensory areas to be considered are STP (superior temporal polysensory area) and area 7a. Macaque STP has some connectivity with mCSv in the study of De Castro et al (2021), though this was not mirrored in humans (Smith et al 2018). STP (STPms in human) responds to visual, auditory and tactile stimuli in both macaques (Bruce et al 1981) and humans (Beauchamp et al 2008) but it has no reported vestibular activity and visual motion responses are associated more with object-motion than self-motion (Hietanen and Perrett 1997).…”

Section: Sources Of Sensory Data For Csvmentioning

confidence: 99%

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Cortical visual area CSv as a cingulate motor area: a sensorimotor interface for the control of locomotion

Smith

2021

Brain Struct Funct

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The response properties, connectivity and function of the cingulate sulcus visual area (CSv) are reviewed. Cortical area CSv has been identified in both human and macaque brains. It has similar response properties and connectivity in the two species. It is situated bilaterally in the cingulate sulcus close to an established group of medial motor/premotor areas. It has strong connectivity with these areas, particularly the cingulate motor areas and the supplementary motor area, suggesting that it is involved in motor control. CSv is active during visual stimulation but only if that stimulation is indicative of self-motion. It is also active during vestibular stimulation and connectivity data suggest that it receives proprioceptive input. Connectivity with topographically organized somatosensory and motor regions strongly emphasizes the legs over the arms. Together these properties suggest that CSv provides a key interface between the sensory and motor systems in the control of locomotion. It is likely that its role involves online control and adjustment of ongoing locomotory movements, including obstacle avoidance and maintaining the intended trajectory. It is proposed that CSv is best seen as part of the cingulate motor complex. In the human case, a modification of the influential scheme of Picard and Strick (Picard and Strick, Cereb Cortex 6:342–353, 1996) is proposed to reflect this.

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Section: Sources Of Sensory Data For Csvmentioning

confidence: 99%

Section: Sources Of Sensory Data For Csvmentioning

confidence: 99%

Cortical visual area CSv as a cingulate motor area: a sensorimotor interface for the control of locomotion

Smith

2021

Brain Struct Funct

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“…On one hand, there is evidence that PCC and RSC directly project to entorhinal and parahippocampal cortices ( Rosene and Van Hoesen, 1977 ; Vogt et al, 1979 ; Insausti et al, 1987 ; Vogt et al, 1987 ; Morecraft et al, 1989 ). On the other hand, these areas are also heavily connected with cortical areas including area 7a ( Pandya et al, 1981 ; Vogt et al, 1987 ; Musil and Olson, 1988 ; Cavada and Goldman-Rakic, 1989 ; Olson and Musil, 1992 ; Shinder and Taube, 2010 ), MSTd ( Akbarian et al, 1994 ; De Castro et al, 2020 ), FEF ( De Castro et al, 2020 ), PIVC, VPS and 3a ( Guldin and Grüsser, 1998 ; De Castro et al, 2020 ). Thus, posterior cingulate region may be one important hub mediating the propagation of self-motion signals from parietal-temporal cortices to the hippocampal-entorhinal system.…”

Section: Introductionmentioning

confidence: 99%

Robust vestibular self-motion signals in macaque posterior cingulate region

Liu

Tian

2021

eLife

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Self-motion signals, distributed ubiquitously across parietal-temporal lobes, propagate to limbic hippocampal system for vector-based navigation via hubs including posterior cingulate cortex (PCC) and retrosplenial cortex (RSC). Although numerous studies have indicated posterior cingulate areas are involved in spatial tasks, it is unclear how their neurons represent self-motion signals. Providing translation and rotation stimuli to macaques on a 6-degree-of-freedom motion platform, we discovered robust vestibular responses in PCC. A combined three-dimensional spatiotemporal model captured data well and revealed multiple temporal components including velocity, acceleration, jerk, and position. Compared to PCC, RSC contained moderate vestibular temporal modulations and lacked significant spatial tuning. Visual self-motion signals were much weaker in both regions compared to the vestibular signals. We conclude that macaque posterior cingulate region carries vestibular-dominant self-motion signals with plentiful temporal components that could be useful for path integration.

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“…In addition, there is a functional link between the left FEF and short-term memory for target locations (Campana et al, 2007;Raabe et al, 2013), as well as a link with visuo-motor integration, requiring for visually guided movements (Wolynski et al, 2009). Research in nonhuman primates further showed that the FEF may be sub-divided into at least two parts (Tian and Lynch, 1996;Petit and Haxby, 1999;Krauzlis, 2004;De Castro et al, 2021): A medial part likely specialized in controlling smooth eye movements (FEFsem) and a lateral part likely specialized in saccadic eye movements (FEFsac). In close exchange with the FEFs are the supplementary eye fields (SEFs).…”

Section: Introductionmentioning

confidence: 99%

Cortical Thickness Related to Compensatory Viewing Strategies in Patients With Macular Degeneration

et al. 2021

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Retinal diseases like age-related macular degeneration (AMD) or hereditary juvenile macular dystrophies (JMD) lead to a loss of central vision. Many patients compensate for this loss with a pseudo fovea in the intact peripheral retina, the so-called “preferred retinal locus” (PRL). How extensive eccentric viewing associated with central vision loss (CVL) affects brain structures responsible for visual perception and visually guided eye movements remains unknown. CVL results in a reduction of cortical gray matter in the “lesion projection zone” (LPZ) in early visual cortex, but the thickness of primary visual cortex appears to be largely preserved for eccentric-field representations. Here we explore how eccentric viewing strategies are related to cortical thickness (CT) measures in early visual cortex and in brain areas involved in the control of eye movements (frontal eye fields, FEF, supplementary eye fields, SEF, and premotor eye fields, PEF). We determined the projection zones (regions of interest, ROIs) of the PRL and of an equally peripheral area in the opposite hemifield (OppPRL) in early visual cortex (V1 and V2) in 32 patients with MD and 32 age-matched controls (19–84 years) by functional magnetic resonance imaging. Subsequently, we calculated the CT in these ROIs and compared it between PRL and OppPRL as well as between groups. Additionally, we examined the CT of FEF, SEF, and PEF and correlated it with behavioral measures like reading speed and eccentric fixation stability at the PRL. We found a significant difference between PRL and OppPRL projection zones in V1 with increased CT at the PRL, that was more pronounced in the patients, but also visible in the controls. Although the mean CT of the eye fields did not differ significantly between patients and controls, we found a trend to a positive correlation between CT in the right FEF and SEF and fixation stability in the whole patient group and between CT in the right PEF and reading speed in the JMD subgroup. The results indicate a possible association between the compensatory strategies used by patients with CVL and structural brain properties in early visual cortex and cortical eye fields.

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Connectivity of the Cingulate Sulcus Visual Area (CSv) in Macaque Monkeys

Cited by 13 publications

References 77 publications

Cortical visual area CSv as a cingulate motor area: a sensorimotor interface for the control of locomotion

Cortical visual area CSv as a cingulate motor area: a sensorimotor interface for the control of locomotion

Robust vestibular self-motion signals in macaque posterior cingulate region

Cortical Thickness Related to Compensatory Viewing Strategies in Patients With Macular Degeneration

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