Connective Tissue VII. Changes in Protein and Hexosamine Content of Bone and Cartilage of Rats at Different Ages.

Age Changes of Dry Weight and Collagen Content of the Skeleton of the Rat

“…The collagen values which we found are in agreement with those of K a o et al [4], who estimated collagen in the femur of 30-month-old rats. They compared their values with those of 5-weck-old animals which showed higher relative values.…”

Changes with Age in Carbohydrate-Protein Complexes of Protein Polysaccharide Light Fraction of Rat Costal Cartilage

“…Data have been published from our laboratory on the change of protein and hexosamine with age in various fractions of cartilage and bone of rats (13). We found that both protein and hexosamine decreased with increasing age in several soluble fractions.…”

Aging in Connective Tissue: A Dynamic Process*

“…per 100 gm. There was a decrease in nonscleroprotein with age in all bones studied [skull, femur, rib and vertebra (12)]. Vertebral cartilage showed no change with aging.…”

“…Tissue was obtained from the tail tendon, aorta, skin, uterus, lung, muscle, heart, liver, kidney, spleen and various bones of Wistar‐strain rats aged 3–5 weeks, 8 months and 2 years, respectively. These tissues were analyzed for their content of soluble protein, soluble or tropocollagen, insoluble collagen and elastin by methods described in previous publications (9–12). Also, the aorta, skin, tendons and uterus of rats of similar ages were analyzed for various tissue lipids, specifically total cholesterol, ester cholesterol, phospholipids and total triglycerides (13–16).…”

“…Also, the aorta, skin, tendons and uterus of rats of similar ages were analyzed for various tissue lipids, specifically total cholesterol, ester cholesterol, phospholipids and total triglycerides (13–16). Hexosamine determinations were made on these same tissues by methods already described (10, 12, 14, 17). The protein‐bound hexosamine of plasma and erythrocytes in both normal and diabetic rats and human beings was studied (17).…”