Connective Tissue Growth Factor in Normal and Pathological Processes

Тополянская, С. В.

doi:10.20514/2226-6704-2020-10-4-254-261

Cited by 2 publications

(1 citation statement)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PYD was first isolated from bovine achilles tendon and described by D. Fujimotto, et al (1977) [3], it is comprised in collagen fibers of bone and cartilage tissues while never found in skin collagen [4]. Some research claim the predictive value of PYD determining in patients with rheumatoid arthritis and other connective tissue pathologies in joints [5][6][7].…”

Section: Relevancementioning

confidence: 99%

Pyridinoline in Evaluation of Subchondral Remodeling and Cartilaginous Tissue Metabolism in Patients With Early Signs of Knee Osteoarthrosis

Белова

Гладкова

Zubavlenko

et al. 2022

Preprint

View full text Add to dashboard Cite

Osteoarthrosis is a polyetiological disease affecting 15 to 85 percent of people over 40 years of age. It makes as much as 50 percent of all articular pathology cases, so the interest of the scientific community in this problem keeps growing. One of the key patterns of osteoarthrosis progressing is the disorder of metabolic processes in articular connective tissue and, in particular, the disorder of collagen synthesis and disorganization of the spatial orientation of collagen molecules. Pyridinoline (PYD) is the integral indicator of this disorganization; it ensures the stability of collagen matrix due to the formation of pyridine crosslinks. Some research claim the predictive value of PYD determining in patients with rheumatoid arthritis and other connective tissue pathologies in joints. Our study involved 42 patients aged 36-50 years with early signs of knee osteoarthrosis and 19 virtually healthy individuals without articular pathologies. All patients underwent standard radiography of their knee joints in the anterior (maximally extended position of the knee joint) and lateral (joint flexion up to 15º) projections in the supine position. Bone formation was assessed by osteocalcin (OC) content and bone resorption by CrossLaps and PYD levels while cartilage matrix destruction by cartilage oligomeric matrix protein (COMP) and cartilage glycoprotein (YKL-40) serum concentrations with enzyme immunoassay (ELISA) method. Our findings showed that the disorders of bone formation (increased OC level) and bone resorption (increased CrossLaps and PYD levels) as well as the rearrangement of the cartilage matrix structure featured by the increased COMP and YKL-40 contents were specific for patients with early signs of knee osteoarthrosis lacking evident clinical and radiological manifestations of the disease. Interestingly, the significant (p<0.05) increase in pyridinoline serum concentration possibly resulted from the intermolecular disbanding in collagen polypeptide chains as a structure-forming component of the extracellular matrix in connective tissue. The sensitivity and specificity assessment of changes in PYD serum concentrations reneders the use of this indicator in the comprehensive evaluation of the condition of patients with early signs of knee osteoarthrosis aimed at increasing the effectiveness of diagnostic approaches to early osteoarthrosis detection and the designning pathogenetic therapy to be a promising trend for further research.

show abstract

Section: Relevancementioning

confidence: 99%

Pyridinoline in Evaluation of Subchondral Remodeling and Cartilaginous Tissue Metabolism in Patients With Early Signs of Knee Osteoarthrosis

Белова

Гладкова

Zubavlenko

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Features of Wound Healing in Patients with Neuroendocrine Pathologies

Морозов

Михайлович²,

Сергеев

et al. 2021

VECS

View full text Add to dashboard Cite

This study allows understanding the course of the process of tissue regeneration in the pathology of the nervous and endocrine systems. These systems are closely interconnected. The integrity of their pathogenic actions on the body is called neroendocrinopathies. They affect body tissues and especially the skin epithelium, independently causing dystrophies and changing their healing rate and regeneration of wounds received during the course of the disease. The wound healing rate depends on many factors, such as age, nutritional status and body weight, body immune status, and chronic comorbidities. The endocrine and nervous system disorders affect oxygenation, hormonal imbalance and nutrient supply of local tissues and the whole body. A wide range of diseases in humans, such as atopic dermatitis, psoriasis, herpes zoster, arthritis, diabetes is characterized by a distinct neurogenic and endocrine component. Micro- and macroangiopathy develops, carbohydrate metabolism in tissues suffers and immunity disorders occur. This disrupts the course of the wound healing process and slows down the recovery processes.

show abstract

Connective Tissue Growth Factor in Normal and Pathological Processes

Cited by 2 publications

References 57 publications

Pyridinoline in Evaluation of Subchondral Remodeling and Cartilaginous Tissue Metabolism in Patients With Early Signs of Knee Osteoarthrosis

Pyridinoline in Evaluation of Subchondral Remodeling and Cartilaginous Tissue Metabolism in Patients With Early Signs of Knee Osteoarthrosis

Features of Wound Healing in Patients with Neuroendocrine Pathologies

Contact Info

Product

Resources

About